Protein Alignment AstA-R2 and OPRL1

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001305782.1
• Gene: OPRL1 / 4987
• HGNCID: 8155
• Length: 399
• Species: Homo sapiens
• Alignment Length: 324
• Identity: 116/324 - (35%)
• Similarity: 177/324 - (54%)
• Gaps: 29/324 - (8%)

  Fly    40 IVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYW 104
            |||.:..| .:.|..||.||:.|::.:..|::.||:.|.|||.||.: |:|.:||..||.::.:|
Human    54 IVGLYLAV-CVGGLLGNCLVMYVILRHTKMKTATNIYIFNLALADTL-VLLTLPFQGTDILLGFW 116

  Fly   105 PYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVV 169
            |:|...|::|..:.....|.|.:||..||:||::|:.||||:..:||.:......|.:|.:..||
Human   117 PFGNALCKTVIAIDYYNMFTSTFTLTAMSVDRYVAICHPIRALDVRTSSKAQAVNVAIWALASVV 181

  Fly   170 SVPVAFTHDVVVDYDAKKNITYGMCTF---TTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMI 231
            .||||......|:.:..:      |..   |..|:.|| .:.:..|:.|:::|:::||..|..||
Human   182 GVPVAIMGSAQVEDEEIE------CLVEIPTPQDYWGP-VFAICIFLFSFIVPVLVISVCYSLMI 239

  Fly   232 MRLWRQGTGVRM---SKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLV 293
            .||    .|||:   |:|..|..:|:||||:|||..|...|.|||:.:|.:.|.| :.::.|.:.
Human   240 RRL----RGVRLLSGSREKDRNLRRITRLVLVVVAVFVGCWTPVQVFVLAQGLGV-QPSSETAVA 299

  Fly   294 IQVTAQTLAYSSSCINPLLYAFLSENFRKAFYK---------AVNCSSRYQNYTSDLPPPRKTS 348
            |......|.|.:||:||:|||||.|||:..|.|         .|..|.|.::...|:....|||
Human   300 ILRFCTALGYVNSCLNPILYAFLDENFKACFRKFCCASALRRDVQVSDRVRSIAKDVALACKTS 363

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	107/289 (37%)
		TM helix 1	40..66	CDD:320224	10/25 (40%)
		TM helix 2	73..99	CDD:320224	13/25 (52%)
		TM helix 3	111..141	CDD:320224	11/29 (38%)
		TM helix 4	153..173	CDD:320224	5/19 (26%)
		TM helix 5	204..233	CDD:320224	9/28 (32%)
		TM helix 6	249..279	CDD:320224	15/29 (52%)
		TM helix 7	292..317	CDD:320224	11/24 (46%)
OPRL1	NP_001305782.1	7tmA_NOFQ_opioid_R	52..330	CDD:320220	107/289 (37%)
		TM helix 1	53..79	CDD:320220	10/25 (40%)
		TM helix 2	86..112	CDD:320220	14/26 (54%)
		TM helix 3	123..153	CDD:320220	11/29 (38%)
		TM helix 4	165..187	CDD:320220	7/21 (33%)
		TM helix 5	212..241	CDD:320220	10/29 (34%)
		TM helix 6	256..286	CDD:320220	15/29 (52%)
		TM helix 7	298..323	CDD:320220	11/24 (46%)