Protein Alignment AstA-R2 and OPRK1

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001305426.1
• Gene: OPRK1 / 4986
• HGNCID: 8154
• Length: 409
• Species: Homo sapiens
• Alignment Length: 329
• Identity: 102/329 - (31%)
• Similarity: 172/329 - (52%)
• Gaps: 30/329 - (9%)

  Fly    33 INGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTAT 97
            |:..:|.|:...:.|:.:.|..||.||:.|::....|::.||:.|.|||.||.: |...:||.:|
Human    54 ISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADAL-VTTTMPFQST 117

  Fly    98 DYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTL 162
            .|::..||:|...|:.|..:.....|.||:||.:||:||::||.||:::...||.....|..:.:
Human   118 VYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICI 182

  Fly   163 WIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCT--FTTNDFLGPRTY-QVTFFISSYLLPLMIIS 224
            |:    :|..|..:..|:.....::::....|:  |..:|:.....: ::..||.::::|::||.
Human   183 WL----LSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIII 243

  Fly   225 GLYMRMIMRLWRQGTGVRM---SKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIET 286
            ..|..||:||    ..||:   |:|..|..:|:||||:|||..|...|.|:.:.:|:::|.....
Human   244 VCYTLMILRL----KSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSH 304

  Fly   287 NTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNCSSRYQNYTSDLPPPRKTSCAR 351
            :| ..|........|.|::|.:||:|||||.|||::.|              .|...|.|....|
Human   305 ST-AALSSYYFCIALGYTNSSLNPILYAFLDENFKRCF--------------RDFCFPLKMRMER 354

  Fly   352 TSTT 355
            .||:
Human   355 QSTS 358

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	93/290 (32%)
		TM helix 1	40..66	CDD:320224	8/25 (32%)
		TM helix 2	73..99	CDD:320224	12/25 (48%)
		TM helix 3	111..141	CDD:320224	12/29 (41%)
		TM helix 4	153..173	CDD:320224	3/19 (16%)
		TM helix 5	204..233	CDD:320224	8/29 (28%)
		TM helix 6	249..279	CDD:320224	13/29 (45%)
		TM helix 7	292..317	CDD:320224	10/24 (42%)
OPRK1	NP_001305426.1	7tmA_Kappa_opioid_R	60..341	CDD:320219	93/290 (32%)
		TM helix 1	61..87	CDD:320219	8/25 (32%)
		TM helix 2	94..120	CDD:320219	12/26 (46%)
		TM helix 3	131..161	CDD:320219	12/29 (41%)
		TM helix 4	173..195	CDD:320219	4/25 (16%)
		TM helix 5	223..252	CDD:320219	8/28 (29%)
		TM helix 6	267..297	CDD:320219	13/29 (45%)
		TM helix 7	309..334	CDD:320219	10/24 (42%)