Protein Alignment AstA-R2 and NMBR

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_002502.2
• Gene: NMBR / 4829
• HGNCID: 7843
• Length: 390
• Species: Homo sapiens
• Alignment Length: 363
• Identity: 98/363 - (26%)
• Similarity: 185/363 - (50%)
• Gaps: 25/363 - (6%)

  Fly     7 LANISLNATRNEENITSFFTDEEWL-AINGT-----LPWIVGFFFGVIAITGFFGNLLVILVVVF 65
            |:|:|:....||........:.::| |.:||     :..::...:.:|...|..||::::.:.:.
Human     6 LSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFIT 70

  Fly    66 NNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLV 130
            |:.|||..|:.|.||||.||:.::.|:|..|:.|....|.:|:..|:.:..:.:.:...|::||.
Human    71 NSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLT 135

  Fly   131 LMSIDRFLAVVHPIRSRMMRTENI---TLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYG 192
            .:|.||:.|:|:|:.   |:|...   |.:..:.:|:|.::::||.|...: |....:..|.::.
Human   136 ALSADRYRAIVNPMD---MQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSE-VARISSLDNSSFT 196

  Fly   193 MC-TFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMIMRLWRQ-----GTGVRMSKESQRGR 251
            .| .:...|.|.|:.:.|..|:..:|:||.|||..|..:...|.:.     |.....:|:....|
Human   197 ACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETR 261

  Fly   252 KRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETN-TLTKLVIQVTAQTLAYSSSCINPLLYAF 315
            ||:.::|:|.|..|...|.|..::.:.:|.:..|.: :|..:::.:.|:.|::.:||:||.....
Human   262 KRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYL 326

  Fly   316 LSENFRKAFYKAVNCSSR-YQ----NYTSDLPPPRKTS 348
            |||:||:.|...:.|..: ||    :|.......|.||
Human   327 LSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTS 364

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	81/294 (28%)
		TM helix 1	40..66	CDD:320224	4/25 (16%)
		TM helix 2	73..99	CDD:320224	11/25 (44%)
		TM helix 3	111..141	CDD:320224	8/29 (28%)
		TM helix 4	153..173	CDD:320224	4/22 (18%)
		TM helix 5	204..233	CDD:320224	10/28 (36%)
		TM helix 6	249..279	CDD:320224	9/29 (31%)
		TM helix 7	292..317	CDD:320224	6/24 (25%)
NMBR	NP_002502.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..22		5/15 (33%)
		7tmA_NMBR	44..335	CDD:320253	81/294 (28%)
		TM helix 1	45..71	CDD:320253	4/25 (16%)
		TM helix 2	78..104	CDD:320253	11/25 (44%)
		TM helix 3	116..146	CDD:320253	8/29 (28%)
		TM helix 4	158..178	CDD:320253	4/19 (21%)
		TM helix 5	209..234	CDD:320253	10/24 (42%)
		TM helix 6	259..289	CDD:320253	9/29 (31%)
		TM helix 7	303..328	CDD:320253	6/24 (25%)