Protein Alignment AstA-R2 and MTNR1A

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_005949.1
• Gene: MTNR1A / 4543
• HGNCID: 7463
• Length: 350
• Species: Homo sapiens
• Alignment Length: 346
• Identity: 85/346 - (24%)
• Similarity: 157/346 - (45%)
• Gaps: 54/346 - (15%)

  Fly    34 NGTLP-WIVGFFFGVIAIT---GFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPF 94
            :|..| |:......|:..|   ...|||||||.|..|..:|:..|:.:|:||.|||:..|...|.
Human    19 DGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPL 83

  Fly    95 TATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAI 159
            .........|..|...|:...:|:.::...||:.:..::|:|:..:.|.::...:.:...:|..:
Human    84 VLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYV 148

  Fly   160 VTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTF--FISS------- 215
            :.:|::.|...:|               |:..|...:      .||.|..||  .:||
Human   149 LLIWLLTLAAVLP---------------NLRAGTLQY------DPRIYSCTFAQSVSSAYTIAVV 192

  Fly   216 ---YLLPLMIISGLYMR---MIMRLWRQGTGVRMSK-ESQRGRKRVTRLVVVVVIAFASLWLPVQ 273
               :|:|::|:...|:|   :::::.::....|..| :.|..|..||..||.|:  ||..|.|:.
Human   193 VFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVL--FAICWAPLN 255

  Fly   274 LILLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAV--NCSSR--Y 334
            .|.|..:.|...........:.|.:..:||.:||:|.::|..|::||||.:.:.:  .|::|  :
Human   256 FIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFF 320

  Fly   335 QNYTSDL-------PPPRKTS 348
            .:.::|:       |.|..|:
Human   321 VDSSNDVADRVKWKPSPLMTN 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	77/303 (25%)
		TM helix 1	40..66	CDD:320224	10/28 (36%)
		TM helix 2	73..99	CDD:320224	9/25 (36%)
		TM helix 3	111..141	CDD:320224	6/29 (21%)
		TM helix 4	153..173	CDD:320224	3/19 (16%)
		TM helix 5	204..233	CDD:320224	12/43 (28%)
		TM helix 6	249..279	CDD:320224	12/29 (41%)
		TM helix 7	292..317	CDD:320224	7/24 (29%)
MTNR1A	NP_005949.1	7tm_GPCRs	28..306	CDD:475119	76/300 (25%)
		TM helix 1	30..54	CDD:410628	10/23 (43%)
		TM helix 2	63..85	CDD:410628	9/21 (43%)
		TM helix 3	101..123	CDD:410628	3/21 (14%)
		TM helix 4	146..162	CDD:410628	3/30 (10%)
		TM helix 5	185..208	CDD:410628	4/22 (18%)
		TM helix 6	237..259	CDD:410628	10/23 (43%)
		TM helix 7	274..299	CDD:410628	7/24 (29%)