DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment AstA-R2 and Hcrtr2

DIOPT Version :10

Sequence 1:NP_524544.1 Gene:AstA-R2 / 43393 FlyBaseID:FBgn0039595 Length:357 Species:Drosophila melanogaster
Sequence 2:NP_945200.1 Gene:Hcrtr2 / 387285 MGIID:2680765 Length:460 Species:Mus musculus


Alignment Length:369 Identity:100/369 - (27%)
Similarity:178/369 - (48%) Gaps:65/369 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 EWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIP 93
            ||:.|.|.:         ::.:....||:||.:.|..|::||:.||..||||:.||::..|.|:|
Mouse    54 EWVLIAGYI---------IVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLP 109

  Fly    94 FTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPI--RSRMMRTENITL 156
            .|....:...|.:|:..|:.:.||..|:...|:.||..:::||:.|:.||:  :|...|..|   
Mouse   110 ATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARN--- 171

  Fly   157 IAIVTLWIVVLVVSVPVAFTHDVVVDYD------AKKNITYGMCTFTTNDFLGPRTYQVTFFISS 215
             :||.:|||..::.:|.|    :|::..      |.|...:.:|.......:.|:.|.:.||:.:
Mouse   172 -SIVVIWIVSCIIMIPQA----IVMECSSMLPGLANKTTLFTVCDEHWGGEVYPKMYHICFFLVT 231

  Fly   216 YLLPLMIISGLYMRMIMRLW-RQGTGV-----RMSKESQ-------------------------- 248
            |:.||.::...|:::..:|| ||..|.     |..|:.|                          
Mouse   232 YMAPLCLMILAYLQIFRKLWCRQIPGTSSVVQRKWKQQQPVSQPRGSGQQSKARISAVAAEIKQI 296

  Fly   249 RGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQ---VTAQTLAYSSSCINP 310
            |.|::..|:::||::.||..:||:.::.:||.:..:.|:|..:..:.   ..:..|.|::|..||
Mouse   297 RARRKTARMLMVVLLVFAICYLPISILNVLKRVFGMFTHTEDRETVYAWFTFSHWLVYANSAANP 361

  Fly   311 LLYAFLSENFRKAFYKAVNCSSRYQNYTSDLPPPRKTSCARTST 354
            ::|.|||..||:.|..|.:|.....:...|     :.:..||||
Mouse   362 IIYNFLSGKFREEFKAAFSCCLGVHHRQGD-----RLARGRTST 400

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AstA-R2NP_524544.1 7tmA_AstA_R_insect 39..324 CDD:320224 88/327 (27%)
TM helix 1 40..66 CDD:320224 5/25 (20%)
TM helix 2 73..99 CDD:320224 12/25 (48%)
TM helix 3 111..141 CDD:320224 10/29 (34%)
TM helix 4 153..173 CDD:320224 6/19 (32%)
TM helix 5 204..233 CDD:320224 8/28 (29%)
TM helix 6 249..279 CDD:320224 9/29 (31%)
TM helix 7 292..317 CDD:320224 7/27 (26%)
Hcrtr2NP_945200.1 Required for response to orexin-A. /evidence=ECO:0000250|UniProtKB:O43614 33..49
7tmA_OXR 55..375 CDD:320336 91/336 (27%)
TM helix 1 56..82 CDD:320336 7/34 (21%)
TM helix 2 89..115 CDD:320336 12/25 (48%)
TM helix 3 127..157 CDD:320336 10/29 (34%)
TM helix 4 168..189 CDD:320336 9/28 (32%)
TM helix 5 220..249 CDD:320336 8/28 (29%)
TM helix 6 297..327 CDD:320336 9/29 (31%)
TM helix 7 343..368 CDD:320336 7/24 (29%)
Orexin_rec2 386..443 CDD:427531 5/20 (25%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.