Protein Alignment AstA-R2 and HTR1A

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_000515.2
• Gene: HTR1A / 3350
• HGNCID: 5286
• Length: 422
• Species: Homo sapiens
• Alignment Length: 395
• Identity: 80/395 - (20%)
• Similarity: 141/395 - (35%)
• Gaps: 119/395 - (30%)

  Fly    40 IVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYW 104
            |.....|.:......||..|:..:....::::..|.:|.:||..|||..:|.:|..|...::..|
Human    38 ITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKW 102

  Fly   105 PYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVV 169
            ..|:..|.....|.|:...:||..|..:::||:.|:..||.....||.......|...|::..::
Human   103 TLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLI 167

  Fly   170 SVPVAF---THDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMI 231
            |:|...   |.:...|.||        ||.:.:     ..|.:.....::.:||:::..||.|:.
Human   168 SIPPMLGWRTPEDRSDPDA--------CTISKD-----HGYTIYSTFGAFYIPLLLMLVLYGRIF 219

  Fly   232 ----------------------------------------MRLWRQGT------------GVRM- 243
                                                    .|.||.|.            .||.
Human   220 RAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQG 284

  Fly   244 ----------------SKE-----SQRG--------------------------RKRVT-RLVVV 260
                            |||     |:.|                          |:|.| :.:.:
Human   285 DDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGI 349

  Fly   261 VVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFY 325
            ::..|...|||..::.|:  |...|::.....::......|.||:|.:||::||:.:::|:.||.
Human   350 IMGTFILCWLPFFIVALV--LPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFK 412

  Fly   326 KAVNC 330
            |.:.|
Human   413 KIIKC 417

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	76/387 (20%)
		TM helix 1	40..66	CDD:320224	5/25 (20%)
		TM helix 2	73..99	CDD:320224	10/25 (40%)
		TM helix 3	111..141	CDD:320224	9/29 (31%)
		TM helix 4	153..173	CDD:320224	3/19 (16%)
		TM helix 5	204..233	CDD:320224	6/68 (9%)
		TM helix 6	249..279	CDD:320224	9/56 (16%)
		TM helix 7	292..317	CDD:320224	8/24 (33%)
HTR1A	NP_000515.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		7tmA_5-HT1A_vertebrates	37..411	CDD:320453	76/387 (20%)
		TM helix 1	38..64	CDD:320453	5/25 (20%)
		TM helix 2	71..97	CDD:320453	10/25 (40%)
		TM helix 3	109..139	CDD:320453	9/29 (31%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	4/21 (19%)
		TM helix 5	192..221	CDD:320453	6/33 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..262		0/26 (0%)
		TM helix 6	338..368	CDD:320453	8/31 (26%)
		TM helix 7	379..404	CDD:320453	8/24 (33%)
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400		2/3 (67%)