DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and Rgr

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	XP_038950404.1	Gene:	Rgr / 306307	RGDID:	1309174	Length:	300	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	83/355 - (23%)
Similarity:	139/355 - (39%)	Gaps:	84/355 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LNATRNEENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLM 76
            :.|||   .:.:.|.:.|.|||        |....:.|::|...|.|.|.......::|:.:||:
  Rat     1 MTATR---ALPAGFGELEVLAI--------GIVLLMEALSGISLNGLTIFSFCKTPDLRTPSNLL 54

  Fly    77 IVNLAAAD--------------LMFVILCIPFTATDYMVYY--WPYGRFWCRSVQYLIVVTAFAS 125
            :::||.||              |:.|||.|        |.:  ||:|...||...:....||.||
  Rat    55 VLSLALADTGISLNALVAAVSSLLRVILPI--------VSHRRWPHGSEGCRVHGFQGFATALAS 111

  Fly   126 IYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWI-VVLVVSVP-VAFTHDVVVDYDAKKN 188
            |.....::..|:    |...:|.....:..:..::.:|: .....|:| :.:.|   .||:
  Rat   112 ICGSAAIAWGRY----HHYCTRRQLAWDTAIPLVLFVWLSSAFWASLPLMGWGH---YDYE---- 165

  Fly   189 ITYGMCTFTTNDF-LGPRT-----YQVTFFISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSKES 247
             ..|.|  .|.|: .|.|.     :.:.||  ::|:||.|....|..|..:|.|.|
  Rat   166 -PVGTC--CTLDYSRGDRNFISFLFTMAFF--NFLVPLFITHTSYRFMEQKLSRSG--------- 216

  Fly   248 QRGRKRVTRLVVVVVIAFASL---WLPVQLILLLKSL-DVIETNTLTKLVIQVTAQTLAYSSSCI 308
                    .|.|...:....|   |.|..|:.|..:: ||...:...::|..:.|:|:    ..|
  Rat   217 --------HLQVNTTLPGRMLLLGWGPYALLYLYAAVADVSFISPKLQMVPALIAKTM----PTI 269

  Fly   309 NPLLYAFLSENFRKAFYKAVNCSSRYQNYT 338
            |.:.||..||...:..::..:.....|:.|
  Rat   270 NAINYALRSEMVCRGTWQCRSAQKSKQDRT 299

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	31/132 (23%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	66/285 (23%)
Rgr	XP_038950404.1	7tmA_Retinal_GPR	17..286	CDD:320200	76/321 (24%)
		TM helix 1	19..43	CDD:320200	7/31 (23%)
		TM helix 2	52..74	CDD:320200	6/21 (29%)
		TM helix 3	98..120	CDD:320200	6/21 (29%)
		TM helix 4	139..155	CDD:320200	2/15 (13%)
		TM helix 5	183..206	CDD:320200	6/24 (25%)
		TM helix 6	219..241	CDD:320200	5/21 (24%)
		TM helix 7	253..278	CDD:320200	7/28 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930