DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and Galr2

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_062045.1	Gene:	Galr2 / 29234	RGDID:	2657	Length:	372	Species:	Rattus norvegicus

Alignment Length:	393	Identity:	113/393 - (28%)
Similarity:	186/393 - (47%)	Gaps:	79/393 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 NATRNEENITSFFTDEEWLAINGTLPW-----IVGFFFGVIAITGFFGNLLVILVVVFNNNMRST 72
            :.::..||     |.:|    .|:..|     :|..||.:|.:.|..||.||:.|::......||
  Rat     4 SGSQGAEN-----TSQE----GGSGGWQPEAVLVPLFFALIFLVGTVGNALVLAVLLRGGQAVST 59

  Fly    73 TNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRF 137
            |||.|:||..|||.|::.|:||.||.|.:..|.:|...|::|.:||.:|..||.:||..:|:||:
  Rat    60 TNLFILNLGVADLCFILCCVPFQATIYTLDDWVFGSLLCKAVHFLIFLTMHASSFTLAAVSLDRY 124

  Fly   138 LAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVP------------VAFTHDVVVDYDAKKNIT 190
            ||:.:|:.||.:||....|.||..:|.:.|:.|.|            :...|..   :.|.:...
  Rat   125 LAIRYPLHSRELRTPRNALAAIGLIWGLALLFSGPYLSYYRQSQLANLTVCHPA---WSAPRRRA 186

  Fly   191 YGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSKESQRGRKRVT 255
            ..:||                |:.|||||::::|..|.|.:..|||....|.....|||.:::||
  Rat   187 MDLCT----------------FVFSYLLPVLVLSLTYARTLRYLWRTVDPVTAGSGSQRAKRKVT 235

  Fly   256 RLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENF 320
            |::::|.:.|...|:|...::|............| ..:::.:..::|::||:||::||.:|::|
  Rat   236 RMIIIVAVLFCLCWMPHHALILCVWFGRFPLTRAT-YALRILSHLVSYANSCVNPIVYALVSKHF 299

  Fly   321 RKAFYKAV----------------------NCSSRYQNYTSDL-----------PPPRKTSCART 352
            ||.|.|..                      :..|..:..::||           |||...:|..:
  Rat   300 RKGFRKICAGLLRPAPRRASGRVSILAPGNHSGSMLEQESTDLTQVSEAAGPLVPPPALPNCTAS 364

  Fly   353 STT 355
            |.|
  Rat   365 SRT 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	49/116 (42%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	85/269 (32%)
Galr2	NP_062045.1	7tm_4	32..>177	CDD:304433	54/144 (38%)
		7tm_1	42..292	CDD:278431	85/269 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	353..372		6/15 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340927
Domainoid	1	1.000	179	1.000	Domainoid score	I3436
eggNOG	1	0.900	-	-		E33208_3B9CW
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3578
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	1	1.000	-	-		FOG0000972
OrthoInspector	1	1.000	-	-		mtm9131
orthoMCL	1	0.900	-	-		OOG6_105726
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1132
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.700