Protein Alignment AstA-R2 and MLNR

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001498.1
• Gene: MLNR / 2862
• HGNCID: 4495
• Length: 412
• Species: Homo sapiens
• Alignment Length: 349
• Identity: 86/349 - (24%)
• Similarity: 157/349 - (44%)
• Gaps: 72/349 - (20%)

  Fly    38 PWIVGFFFGVIA------ITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTA 96
            |:.:|....|.|      :.|..||::.::::....:||:||||.:.::|.:||: ::|.:||..
Human    32 PFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLL-ILLGLPFDL 95

  Fly    97 TDYMVYY---WPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIA 158
              |.::.   |.:|...||...|:.....:|::..:..:|::|:||:..|:|:|::.|.......
Human    96 --YRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRAL 158

  Fly   159 IVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGM--------CTFTTNDFL------------G 203
            |..||.|.|:.:.|..|.  |.|:.|...::..|:        ....::..|            |
Human   159 IAVLWAVALLSAGPFLFL--VGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSG 221

  Fly   204 PRTYQVTFFISS----------------------YLLPLMIISGLYMRMIMRLWRQGTGVRMSKE 246
            |.|.:.....|.                      :.||.:.:|.||..:...||.....:|....
Human   222 PETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAA 286

  Fly   247 S--QRGRKRVTRLVVVVVIAFASLWLP--VQLILLLKSLDVIETNTLTKLV-----IQVTAQTLA 302
            |  :||.::..|:::|||:||...|||  |..|:.:.:.|       ::::     ..:.|..|.
Human   287 SGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTED-------SRMMYFSQYFNIVALQLF 344

  Fly   303 YSSSCINPLLYAFLSENFRKAFYK 326
            |.|:.|||:||..:|:.:|.|.:|
Human   345 YLSASINPILYNLISKKYRAAAFK 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	83/344 (24%)
		TM helix 1	40..66	CDD:320224	6/31 (19%)
		TM helix 2	73..99	CDD:320224	9/25 (36%)
		TM helix 3	111..141	CDD:320224	8/29 (28%)
		TM helix 4	153..173	CDD:320224	5/19 (26%)
		TM helix 5	204..233	CDD:320224	8/50 (16%)
		TM helix 6	249..279	CDD:320224	13/31 (42%)
		TM helix 7	292..317	CDD:320224	9/29 (31%)
MLNR	NP_001498.1	7tm_GPCRs	39..366	CDD:475119	82/338 (24%)
		TM helix 1	41..65	CDD:410628	5/23 (22%)
		TM helix 2	74..95	CDD:410628	8/21 (38%)
		TM helix 3	112..134	CDD:410628	3/21 (14%)
		TM helix 4	157..173	CDD:410628	5/15 (33%)
		TM helix 5	245..268	CDD:410628	4/22 (18%)
		TM helix 6	297..319	CDD:410628	10/21 (48%)
		TM helix 7	334..359	CDD:410628	9/24 (38%)