Protein Alignment AstA-R2 and NPBWR2

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_005277.2
• Gene: NPBWR2 / 2832
• HGNCID: 4530
• Length: 333
• Species: Homo sapiens
• Alignment Length: 342
• Identity: 105/342 - (30%)
• Similarity: 175/342 - (51%)
• Gaps: 44/342 - (12%)

  Fly     5 TMLANISL------NATRNEENITSFFTDEEWLAINGTLPWIV----GFFFGVIAITGFFGNLLV 59
            ||.||:|.      |||.:|                 .||::.    ..:.|:.|: |..||..|
Human    20 TMGANVSQDNGTGHNATFSE-----------------PLPFLYVLLPAVYSGICAV-GLTGNTAV 66

  Fly    60 ILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFA 124
            |||::....|::.||:.|:|||.||.:|. |.:|....::::.|||:|...|:.|..:.....|:
Human    67 ILVILRAPKMKTVTNVFILNLAVADGLFT-LVLPVNIAEHLLQYWPFGELLCKLVLAVDHYNIFS 130

  Fly   125 SIYTLVLMSIDRFLAVVHPIRSRMM--RTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKK 187
            |||.|.:||:||:|.|:..:|||.|  ||.....:|.:.:|:.|.|:.:|. |:...|  |..:.
Human   131 SIYFLAVMSVDRYLVVLATVRSRHMPWRTYRGAKVASLCVWLGVTVLVLPF-FSFAGV--YSNEL 192

  Fly   188 NITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMIMRLWRQGTGVRM---SKESQR 249
            .:.....:|...:.:..:..:|...:..::||:..|..||..::.||    ..||:   :|...:
Human   193 QVPSCGLSFPWPEQVWFKASRVYTLVLGFVLPVCTICVLYTDLLRRL----RAVRLRSGAKALGK 253

  Fly   250 GRKRVTRLVVVVVIAFASLWLPVQLI-LLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLY 313
            .|::||.||:||:......|.|..|. ::..:.|:.:|..:..:...:|  :|:|::||:||.||
Human   254 ARRKVTVLVLVVLAVCLLCWTPFHLASVVALTTDLPQTPLVISMSYVIT--SLSYANSCLNPFLY 316

  Fly   314 AFLSENFRKAFYKAVNC 330
            |||.:||||.|...:.|
Human   317 AFLDDNFRKNFRSILRC 333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	92/294 (31%)
		TM helix 1	40..66	CDD:320224	9/29 (31%)
		TM helix 2	73..99	CDD:320224	11/25 (44%)
		TM helix 3	111..141	CDD:320224	12/29 (41%)
		TM helix 4	153..173	CDD:320224	4/19 (21%)
		TM helix 5	204..233	CDD:320224	6/28 (21%)
		TM helix 6	249..279	CDD:320224	10/30 (33%)
		TM helix 7	292..317	CDD:320224	11/24 (46%)
NPBWR2	NP_005277.2	7tmA_NPBWR	46..327	CDD:320215	92/291 (32%)
		TM helix 1	47..73	CDD:320215	9/26 (35%)
		TM helix 2	80..106	CDD:320215	11/26 (42%)
		TM helix 3	117..147	CDD:320215	12/29 (41%)
		TM helix 4	161..183	CDD:320215	5/22 (23%)
		TM helix 5	209..238	CDD:320215	6/28 (21%)
		TM helix 6	253..283	CDD:320215	10/29 (34%)
		TM helix 7	295..320	CDD:320215	11/26 (42%)