Protein Alignment AstA-R2 and Cckar

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_036820.1
• Gene: Cckar / 24889
• RGDID: 2289
• Length: 444
• Species: Rattus norvegicus
• Alignment Length: 430
• Identity: 94/430 - (21%)
• Similarity: 178/430 - (41%)
• Gaps: 105/430 - (24%)

  Fly     8 ANISLNATRNEENITSFFTDE-----EWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNN 67
            :||:.......||.|.|..|:     ||.:....|      .:.:|.:....||.|||.|::.|.
  Rat    27 SNITPPCELGLENETLFCLDQPQPSKEWQSALQIL------LYSIIFLLSVLGNTLVITVLIRNK 85

  Fly    68 NMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLM 132
            .||:.||:.:::||.:|||..:.|:||.....::..:.:|...|::..|.:..:...|.:.||.:
  Rat    86 RMRTVTNIFLLSLAVSDLMLCLFCMPFNLIPNLLKDFIFGSAVCKTTTYFMGTSVSVSTFNLVAI 150

  Fly   133 SIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFT 197
            |::|:.|:..|::||:.:|::..|..|...|.:...:..|... :..:|.:....|.|..||.|.
  Rat   151 SLERYGAICRPLQSRVWQTKSHALKVIAATWCLSFTIMTPYPI-YSNLVPFTKNNNQTANMCRFL 214

  Fly   198 TNDFLGPRTYQVTFFISSYLLP--LMIIS------------------------------------ 224
            .......:::|....:..:|||  :|:::
  Rat   215 LPSDAMQQSWQTFLLLILFLLPGIVMVVAYGLISLELYQGIKFDASQKKSAKEKKPSTGSSTRYE 279

  Fly   225 ---GLYM-------RMIMRLWRQGTG------VRMSKESQR--GRKRVTRLVVVVVIAFASLWLP 271
               |.|:       ::.::....|:|      :|.|..:..  .:|||.|:::|:|:.|...|:|
  Rat   280 DSDGCYLQKSRPPRKLELQQLSSGSGGSRLNRIRSSSSAANLIAKKRVIRMLIVIVVLFFLCWMP 344

  Fly   272 VQLILLLKSLDVIE-----TNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNCS 331
            :......::.|.:.     :.|....::     .|:|:|||:||::|.|:::.||..|.....|.
  Rat   345 IFSANAWRAYDTVSAEKHLSGTPISFIL-----LLSYTSSCVNPIIYCFMNKRFRLGFMATFPCC 404

  Fly   332 -------------------------SR--YQNYTSDLPPP 344
                                     ||  |.:.::..|||
  Rat   405 PNPGPPGVRGEVGEEEDGRTIRALLSRYSYSHMSTSAPPP 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	76/345 (22%)
		TM helix 1	40..66	CDD:320224	7/25 (28%)
		TM helix 2	73..99	CDD:320224	10/25 (40%)
		TM helix 3	111..141	CDD:320224	8/29 (28%)
		TM helix 4	153..173	CDD:320224	3/19 (16%)
		TM helix 5	204..233	CDD:320224	7/76 (9%)
		TM helix 6	249..279	CDD:320224	9/31 (29%)
		TM helix 7	292..317	CDD:320224	9/24 (38%)
Cckar	NP_036820.1	CholecysA-Rec_N	16..62	CDD:462713	10/40 (25%)
		7tm_GPCRs	57..397	CDD:475119	77/351 (22%)
		TM helix 1	59..83	CDD:410628	8/29 (28%)
		TM helix 2	92..114	CDD:410628	9/21 (43%)
		TM helix 3	130..152	CDD:410628	4/21 (19%)
		TM helix 4	175..191	CDD:410628	2/15 (13%)
		TM helix 5	222..245	CDD:410628	5/22 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	263..288		2/24 (8%)
		TM helix 6	328..350	CDD:410628	6/21 (29%)
		TM helix 7	365..390	CDD:410628	10/29 (34%)