Protein Alignment AstA-R2 and NTSR2

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_036476.2
• Gene: NTSR2 / 23620
• HGNCID: 8040
• Length: 410
• Species: Homo sapiens
• Alignment Length: 369
• Identity: 81/369 - (21%)
• Similarity: 153/369 - (41%)
• Gaps: 63/369 - (17%)

  Fly    45 FGVIAITGFFGNLLVILVVVFNNNMRS-TTNLMIVNLAAADLMFVILCIPFTATDYMVYY--WPY 106
            :.:|...|..||.|...||:.....|: .....:::||.|.|:.:::.:|.....::.::  |.:
Human    39 YALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVF 103

  Fly   107 GRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSV 171
            |...||...::..:.|:|::.::..:|.:|.|||..|:|:|.:.|...|...:...|...|.:::
Human   104 GDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLAL 168

  Fly   172 PVAF----THDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFF----ISSYLLPLMI---ISG 225
            |:|.    .|::.. .|.:......:||     .|..||....|.    :.|::|||.:   ::|
Human   169 PMAVIMGQKHELET-ADGEPEPASRVCT-----VLVSRTALQVFIQVNVLVSFVLPLALTAFLNG 227

  Fly   226 LYMRMIMRL-------------------------------WR----QGTGVRMSKESQ----RGR 251
            :.:..::.|                               |:    ||..|.:.:...    |..
Human   228 VTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSL 292

  Fly   252 KRVTRLVVVVVIAFASLWLPVQLILLLKSL--DVIETNTLTKL--VIQVTAQTLAYSSSCINPLL 312
            :|..:::..:|:.:...|||.....|:...  |...|:.|...  ...:...||.|.||.:.|||
Human   293 QRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLL 357

  Fly   313 YAFLSENFRKAFYKAVNCSSRYQNYTSDLPPPRKTSCARTSTTG 356
            |..:|.:|||.|.:||:......:....|||..::.....:.:|
Human   358 YNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASG 401

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	74/335 (22%)
		TM helix 1	40..66	CDD:320224	7/20 (35%)
		TM helix 2	73..99	CDD:320224	5/25 (20%)
		TM helix 3	111..141	CDD:320224	8/29 (28%)
		TM helix 4	153..173	CDD:320224	3/19 (16%)
		TM helix 5	204..233	CDD:320224	8/35 (23%)
		TM helix 6	249..279	CDD:320224	7/29 (24%)
		TM helix 7	292..317	CDD:320224	9/26 (35%)
NTSR2	NP_036476.2	7tm_GPCRs	33..369	CDD:475119	74/335 (22%)
		TM helix 1	35..59	CDD:410628	7/19 (37%)
		TM helix 2	69..91	CDD:410628	5/21 (24%)
		TM helix 3	109..131	CDD:410628	3/21 (14%)
		TM helix 4	154..170	CDD:410628	2/15 (13%)
		TM helix 5	204..227	CDD:410628	5/22 (23%)
		TM helix 6	296..318	CDD:410628	4/21 (19%)
		TM helix 7	337..362	CDD:410628	9/24 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	381..410		4/21 (19%)