Protein Alignment AstA-R2 and tkr-1

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_499064.2
• Gene: tkr-1 / 192055
• WormBaseID: WBGene00006576
• Length: 406
• Species: Caenorhabditis elegans
• Alignment Length: 378
• Identity: 93/378 - (24%)
• Similarity: 165/378 - (43%)
• Gaps: 52/378 - (13%)

  Fly     3 NTTMLANISLNATRNEENIT-------SFF---TDEEWLAINGTLPWIVGFFFGVIAITGFFGNL 57
            |...|..:...|.:|.||:|       .||   :..|.||..    ..|...|.::..|...||.
 Worm     2 NQEFLIQLGERACKNAENLTLPAELEGIFFCAPSSRESLATQ----VFVAIAFVLLMATAIIGNS 62

  Fly    58 LVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYY-WPYGRFWCRSVQYLIVVT 121
            :|:.::..:..|....|..:.|:|.|||:..:..:. |:..|.:|| |.||.. |....:..:..
 Worm    63 VVMWIIYQHKVMHYGFNYFLFNMAFADLLIALFNVG-TSWTYNLYYDWWYGDL-CTLTSFFGIAP 125

  Fly   122 AFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVA--------FTHD 178
            ...|:.:::.:|.||..|||:|::.|.:..:. ::|||:.:|:|..|.::|.|        :|:|
 Worm   126 TTVSVCSMMALSWDRCQAVVNPLQKRPLSRKR-SVIAILIIWVVSTVTALPFAIAASVNSLYTYD 189

  Fly   179 VVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMIM--RLWRQGTGV 241
            ||....:|.::    |:...|.|     ::...|...|.||::|:...:.|:.:  |...:.|..
 Worm   190 VVTSTVSKAHV----CSAPVNTF-----FEKVLFGIQYALPIIILGSTFTRIAVAFRATNEATDS 245

  Fly   242 RMSKESQRGRKRVTRLVVVVVIAFASLWLPVQL---ILLLKSLDVIETNTLTKLVIQVTAQTLAY 303
            .:.....|.:.:..:::.::|:||...|||..:   ..|.:..|.........|:..:...:.||
 Worm   246 SLKNNHTRAKSKAVKMLFLMVVAFVVCWLPYHIYHAFALEEFFDAARGKYAYLLIYWIAMSSCAY 310

  Fly   304 SSSCINPLLYAFLSENFRKAF------YKAVNCSSRYQNYTSDLPPPRKTSCA 350
                 ||::|.|.:|.||..|      ...::|......| |.|.|.:..|.|
 Worm   311 -----NPIIYCFANERFRIGFRYVFRWIPVIDCKKEQYEY-SQLFPDKMRSMA 357

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	73/298 (24%)
		TM helix 1	40..66	CDD:320224	6/25 (24%)
		TM helix 2	73..99	CDD:320224	7/25 (28%)
		TM helix 3	111..141	CDD:320224	6/29 (21%)
		TM helix 4	153..173	CDD:320224	6/19 (32%)
		TM helix 5	204..233	CDD:320224	6/30 (20%)
		TM helix 6	249..279	CDD:320224	8/32 (25%)
		TM helix 7	292..317	CDD:320224	7/24 (29%)
tkr-1	NP_499064.2	7tm_GPCRs	44..326	CDD:475119	73/298 (24%)
		TM helix 1	46..70	CDD:320512	6/23 (26%)
		TM helix 2	79..101	CDD:320512	7/22 (32%)
		TM helix 3	116..138	CDD:320512	1/21 (5%)
		TM helix 4	160..176	CDD:320512	6/15 (40%)
		TM helix 5	207..230	CDD:320512	6/27 (22%)
		TM helix 6	259..281	CDD:320512	6/21 (29%)
		TM helix 7	294..319	CDD:320512	7/29 (24%)