DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and npr-14

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_001379223.1	Gene:	npr-14 / 189211	WormBaseID:	WBGene00012275	Length:	425	Species:	Caenorhabditis elegans

Alignment Length:	343	Identity:	102/343 - (29%)
Similarity:	182/343 - (53%)	Gaps:	25/343 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 NTTMLANISLNATRNEENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNN 67
            :|:.:..:.:|.....|:|.:     |.|..|....|.| :....:.:.|..||.||::||..|.
Worm    17 DTSEIIGLQVNTHEEYEDIIA-----EALWPNAVEQWFV-YILASMMVIGVIGNTLVVVVVATNK 75

  Fly    68 NMRSTTNLMIVNLAAADLMFVILCIPFT-ATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVL 131
            :||:..||:::|||.|||:.::.|:|.| ..|....:| :...:|:||.::...:.:.||.:||.
Worm    76 SMRNALNLVLMNLAIADLLILLFCLPLTVVNDVTKTFW-FSAVFCKSVNFVNNTSVYVSIMSLVF 139

  Fly   132 MSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNIT--YG-M 193
            ::.:|:.|:.:|::|..:||.::    |..:|.:.:.:|.|...|..:......:.|.|  :| .
Worm   140 ITCERWRAITYPLKSPFVRTRSV----IGGIWFIAMFLSSPEPVTLHLAGAPFVRPNFTTKWGTR 200

  Fly   194 CTFT-TNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSKESQRGRKRVTRL 257
            |..: :.:|  .:.||:...|.|::|||::||.|.:.|:..|......:.::......||:..|:
Worm   201 CKESWSEEF--QKNYQLLQTIFSFVLPLLVISILCLHMVRTLHFSANYLTVANRQISIRKKAVRM 263

  Fly   258 VVVVVIAFASLWLPVQLILLLKSLDVIET--NTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENF 320
            :..||..|:...|||.|..:..:.|::.|  :|.|..|.::..:..:|||||:||:||:|||..|
Worm   264 LCAVVFLFSMSNLPVHLYNIALNYDLLSTDVSTNTIAVRKLLPRVFSYSSSCLNPILYSFLSGRF 328

  Fly   321 RKAFYKAVNC-----SSR 333
            |:.|.:.|.|     |||
Worm   329 REEFGRVVCCLRDEKSSR 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	37/117 (32%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	79/264 (30%)
npr-14	NP_001379223.1	7tmA_CCKR-like	48..332	CDD:320124	89/291 (31%)
		TM helix 1	49..73	CDD:320124	8/24 (33%)
		TM helix 2	82..104	CDD:320124	10/21 (48%)
		TM helix 3	120..142	CDD:320124	6/21 (29%)
		TM helix 4	161..177	CDD:320124	3/19 (16%)
		TM helix 5	211..234	CDD:320124	10/22 (45%)
		TM helix 6	261..283	CDD:320124	8/21 (38%)
		TM helix 7	300..325	CDD:320124	11/24 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910