Protein Alignment AstA-R2 and npr-20

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_495888.3
• Gene: npr-20 / 188226
• WormBaseID: WBGene00011578
• Length: 410
• Species: Caenorhabditis elegans
• Alignment Length: 423
• Identity: 108/423 - (25%)
• Similarity: 175/423 - (41%)
• Gaps: 110/423 - (26%)

  Fly     1 MENTTMLANISLNATRNEENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVF 65
            |.|.|.  .|..|||.:::..:..|.|:.::.|.      |...:.::.:....||.|.::|:..
 Worm     1 MLNDTF--RIISNATLDDDPCSVSFIDQPFVKIP------VMIIYCLVFVVCLSGNFLTLIVMTS 57

  Fly    66 NNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYY-------WPYGRFWCRSVQYLIVVTAF 123
            :..||:.||..:.|||.|||:..|.||    ...|::.       ||.|...|:....|..:...
 Worm    58 HPMMRTPTNFFLSNLAIADLLVAIFCI----LQNMIHIVGFDHGNWPLGPVMCKLYLGLTNIMPC 118

  Fly   124 ASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKN 188
            .|...|||:|:::::||:||:....:.|.....:|.:.:|::.::|:.|. |.:        .:|
 Worm   119 TSAGILVLVSLEKYIAVLHPLSGLKLLTPEHRWVATMIVWVISILVNFPY-FLY--------AQN 174

  Fly   189 ITY---GMCTFTTNDFLGPRTYQVTF-FISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSKESQ- 248
            .||   ..|      |.|......:| ||..||:||..:..:|.|:...||...:..:.|::|.
 Worm   175 YTYLGVSAC------FRGSMPIWNSFSFIVWYLIPLTALVFIYSRISHLLWTSDSNRQSSRQSHE 233

  Fly   249 -------------------------------------------------------RGRKRVTRLV 258
                                                                   .||::|.||:
 Worm   234 SNGSLERGNGYANTAQPGSSWQMKNGRIVVYKQESLLNVPKREKKVKEPKRPKDTEGRRKVVRLL 298

  Fly   259 VVVVIAFASLWLPVQLILLLKSLDVIETNTLTK----LVIQVTAQTLAYSSSCINPLLYAFLSEN 319
            |.||::||.|..|....||..|   .:|.|:..    ::.|..:....:.||.|||:|||.||:.
 Worm   299 VAVVVSFALLTFPHHARLLYTS---FQTGTICNSNWTMIFQPLSYIFLFISSAINPILYACLSKR 360

  Fly   320 FRKAFYKAVNCS-------SRYQNYT--SDLPP 343
            ||.|....::|.       ||.:|.|  ||:||
 Worm   361 FRNALSDVIHCRKGVFSRISRSRNRTLVSDVPP 393

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	88/355 (25%)
		TM helix 1	40..66	CDD:320224	5/25 (20%)
		TM helix 2	73..99	CDD:320224	11/25 (44%)
		TM helix 3	111..141	CDD:320224	8/29 (28%)
		TM helix 4	153..173	CDD:320224	3/19 (16%)
		TM helix 5	204..233	CDD:320224	9/29 (31%)
		TM helix 6	249..279	CDD:320224	14/29 (48%)
		TM helix 7	292..317	CDD:320224	9/24 (38%)
npr-20	NP_495888.3	7tmA_Trissin_R	32..365	CDD:320140	88/360 (24%)
		TM helix 1	32..58	CDD:320140	5/31 (16%)
		TM helix 2	65..90	CDD:320140	12/28 (43%)
		TM helix 3	106..136	CDD:320140	8/29 (28%)
		TM helix 4	149..170	CDD:320140	4/21 (19%)
		TM helix 5	188..217	CDD:320140	9/28 (32%)
		TM helix 6	289..319	CDD:320140	14/29 (48%)
		TM helix 7	333..358	CDD:320140	9/24 (38%)