DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and npr-24

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_510833.3	Gene:	npr-24 / 187897	WormBaseID:	WBGene00020086	Length:	373	Species:	Caenorhabditis elegans

Alignment Length:	377	Identity:	102/377 - (27%)
Similarity:	169/377 - (44%)	Gaps:	67/377 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LNATRNEENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLM 76
            :|.| ||:|.|......:.:|   .|.|.      :.|:.|...||.|:..:|:..:||:.:|:.
Worm     2 MNNT-NEQNFTEVIDPIKTVA---HLTWC------LTALIGIPANLFVLAAIVYFRDMRTISNIY 56

  Fly    77 IVNLAAADLMFVILC-IP---FTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRF 137
            |.|||.|||:|  || ||   |..:.:..:.|  |...|:.......|:.|||...:.::|.||:
Worm    57 IFNLAVADLLF--LCGIPVSLFAQSSHDGWIW--GPIMCKLYISGNAVSQFASAVFIAILSFDRY 117

  Fly   138 LAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMC-TFTTN-- 199
            |||..||:|:..||........|..||:|::...|: |....::...:......|.| .|..|
Worm   118 LAVCRPIQSKSFRTTQAAFALSVAAWIMVILEMTPL-FLFVKLIKSSSAGEARGGSCMLFVGNVT 181

  Fly   200 ------------------DFLGPRTYQVTF-FISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSK 245
                              :.|..|.:.::: |..|||:||:.:...|.::|:::.::..  :|..
Worm   182 VLESATEMNETLLNEIEQNMLASRRFFISYTFALSYLIPLVAVWYFYFKIILKMCQRKR--QMQT 244

  Fly   246 ESQRGRKRVTRLVVV---VVIAFASLWLPVQLILLLKSLDVIETNTLTK---LVIQVT--AQTLA 302
            :....:||.|::.::   :||::...|||..::..     .||.|...|   |:...|  |..|.
Worm   245 KRTATKKRTTKVTIMGLAIVISYTHCWLPFWIVQW-----SIEANLFEKSKYLLFCCTHFAFALQ 304

  Fly   303 YSSSCINPLLYAFLSENFRKAFYKAVNCSSRYQNYTSDLPPPRKTSCARTST 354
            |.:|..||.||.|||::|:|...|.:..:.           |.|....:.||
Worm   305 YINSAANPFLYVFLSDSFQKNIQKLLRTAK-----------PDKQIMLKNST 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	41/120 (34%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	79/291 (27%)
npr-24	NP_510833.3	7tm_GPCRs	25..326	CDD:391938	89/318 (28%)
		TM helix 1	25..46	CDD:341315	7/26 (27%)
		TM helix 2	53..80	CDD:341315	14/28 (50%)
		TM helix 3	91..121	CDD:341315	10/29 (34%)
		TM helix 4	133..155	CDD:341315	5/22 (23%)
		TM helix 5	185..234	CDD:341315	10/48 (21%)
		TM helix 6	251..281	CDD:341315	8/34 (24%)
		TM helix 7	293..319	CDD:341315	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910