Protein Alignment AstA-R2 and AGTR1

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_000676.1
• Gene: AGTR1 / 185
• HGNCID: 336
• Length: 359
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 92/332 - (27%)
• Similarity: 169/332 - (50%)
• Gaps: 56/332 - (16%)

  Fly    45 FGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIP----FTATDYMVYYWP 105
            :.:|.:.|.|||.||::|:.|...:::..::.::|||.|||.| :|.:|    :||   |.|.||
Human    35 YSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCF-LLTLPLWAVYTA---MEYRWP 95

  Fly   106 YGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVS 170
            :|.:.|:.....:....:||::.|..:||||:||:|||::||:.||..:..:..:.:|::..:.|
Human    96 FGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLAS 160

  Fly   171 VPVAFTHDVVVDYDAKKNITYGMCTF---TTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMIM 232
            :|.....:|.  :....|||  :|.|   :.|..| |....:|..|..:|.|.:||...|    .
Human   161 LPAIIHRNVF--FIENTNIT--VCAFHYESQNSTL-PIGLGLTKNILGFLFPFLIILTSY----T 216

  Fly   233 RLWRQGTGVRMSKESQRGRKR---VTRLVVVVVIAFASLWLPVQLILLLKSL------------D 282
            .:|:   .::.:.|.|:.:.|   :.::::.:|:.|...|:|.|:...|..|            |
Human   217 LIWK---ALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIAD 278

  Fly   283 VIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNCSSRYQNYTSDLPPPRKT 347
            :::|      .:.:|. .:||.::|:|||.|.||.:.|::.|.:.:    :|       .||:..
Human   279 IVDT------AMPITI-CIAYFNNCLNPLFYGFLGKKFKRYFLQLL----KY-------IPPKAK 325

  Fly   348 SCARTST 354
            |.:..||
Human   326 SHSNLST 332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	85/300 (28%)
		TM helix 1	40..66	CDD:320224	8/20 (40%)
		TM helix 2	73..99	CDD:320224	11/29 (38%)
		TM helix 3	111..141	CDD:320224	10/29 (34%)
		TM helix 4	153..173	CDD:320224	2/19 (11%)
		TM helix 5	204..233	CDD:320224	8/28 (29%)
		TM helix 6	249..279	CDD:320224	6/32 (19%)
		TM helix 7	292..317	CDD:320224	9/24 (38%)
AGTR1	NP_000676.1	7tmA_AT1R	29..313	CDD:320320	85/300 (28%)
		TM helix 1	30..56	CDD:320320	8/20 (40%)
		TM helix 2	63..88	CDD:320320	9/25 (36%)
		TM helix 3	101..131	CDD:320320	10/29 (34%)
		TM helix 4	144..165	CDD:320320	3/20 (15%)
		TM helix 5	192..221	CDD:320320	9/35 (26%)
		TM helix 6	233..263	CDD:320320	6/29 (21%)
		TM helix 7	281..306	CDD:320320	10/31 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..359