Protein Alignment AstA-R2 and Oprm1

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001291884.1
• Gene: Oprm1 / 18390
• MGIID: 97441
• Length: 474
• Species: Mus musculus
• Alignment Length: 332
• Identity: 109/332 - (32%)
• Similarity: 168/332 - (50%)
• Gaps: 56/332 - (16%)

  Fly    45 FGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRF 109
            :.::.:.|.|||.||:.|:|....|::.||:.|.|||.||.: ....:||.:.:|::..||:|..
Mouse    75 YSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADAL-ATSTLPFQSVNYLMGTWPFGNI 138

  Fly   110 WCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVA 174
            .|:.|..:.....|.||:||..||:||::||.||:::...||.....|..|..||:...:.:||.
Mouse   139 LCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIVNVCNWILSSAIGLPVM 203

  Fly   175 FTHDVVVDYDAKKNITYGM--CTFTTNDFLGPRTY-----QVTFFISSYLLPLMIISGLYMRMIM 232
            |.        |......|.  ||.|   |..|..|     ::..||.::::|::||:..|..||:
Mouse   204 FM--------ATTKYRQGSIDCTLT---FSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMIL 257

  Fly   233 RLWRQGTGVRM---SKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVI 294
            ||    ..|||   |||..|..:|:||:|:|||..|...|.|:.:.:::|:|..|.
Mouse   258 RL----KSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALITIP--------- 309

  Fly   295 QVTAQT--------LAYSSSCINPLLYAFLSENFRKAFYKAVNC-----------SSRYQNYTSD 340
            :.|.||        |.|::||:||:|||||.|||::.|.:.  |           |:|.:..|.:
Mouse   310 ETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREF--CIPTSSTIEQQNSARIRQNTRE 372

  Fly   341 LPPPRKT 347
            .|....|
Mouse   373 HPSTANT 379

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	102/296 (34%)
		TM helix 1	40..66	CDD:320224	8/20 (40%)
		TM helix 2	73..99	CDD:320224	10/25 (40%)
		TM helix 3	111..141	CDD:320224	12/29 (41%)
		TM helix 4	153..173	CDD:320224	4/19 (21%)
		TM helix 5	204..233	CDD:320224	10/33 (30%)
		TM helix 6	249..279	CDD:320224	11/29 (38%)
		TM helix 7	292..317	CDD:320224	13/32 (41%)
Oprm1	NP_001291884.1	7tmA_Mu_opioid_R	69..347	CDD:320218	102/296 (34%)
		TM helix 1	70..96	CDD:320218	8/20 (40%)
		TM helix 2	103..129	CDD:320218	10/26 (38%)
		TM helix 3	140..170	CDD:320218	12/29 (41%)
		TM helix 4	182..204	CDD:320218	6/21 (29%)
		TM helix 5	229..258	CDD:320218	8/28 (29%)
		TM helix 6	273..303	CDD:320218	11/29 (38%)
		TM helix 7	315..340	CDD:320218	11/24 (46%)
		NPxxY, plays a role in stabilizing the activated conformation of the receptor. /evidence=ECO:0000269|PubMed:26245379	332..336		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	362..383		5/18 (28%)