DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and frpr-18

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_504746.1	Gene:	frpr-18 / 179076	WormBaseID:	WBGene00020586	Length:	432	Species:	Caenorhabditis elegans

Alignment Length:	354	Identity:	76/354 - (21%)
Similarity:	152/354 - (42%)	Gaps:	77/354 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 VIAITGFFGNLLVILVVVFNN-NMRSTT-NLMIVNLAAADLMFVILCIP-------------FTA 96
            ||.:.|.|||.|..  ::|:. :|||:: |:::..|:..|...:.|.||             .:.
Worm    13 VIVLVGIFGNSLSF--ILFSRPHMRSSSVNVLLCALSFFDFSLLTLSIPIFVIPNLDLWANDLSL 75

  Fly    97 TDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVT 161
            :.||.|.       .:.:..:.::....|:|.:|:::::|::||..|::.|:..|...:..|
Worm    76 STYMAYI-------LKLIYPINLMMQTCSVYIMVMITLERWVAVCRPLQVRVWCTPRKSRNA--- 130

  Fly   162 LWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFT--TND-------FLGPRTYQVTFFISSYL 217
              |:|::||   ||.::.|..::.:..:|.....:.  ..|       ::|  .|.:.:.::.:|
Worm   131 --ILVIIVS---AFLYNFVRFFEYRFVVTESGALYEKWLRDPGKHRWYYVG--YYTILYIVTHFL 188

  Fly   218 LPLMIISGLYMRMIMRLWRQGTGVRMSKESQRGRKRVTRLVVVVVIAFASL-WLPVQLILLLKSL 281
            :|..:::.....:|:.:.:.....:|....|:..:..|.::::|...||.. .||   .||..|.
Worm   189 VPFSVMAFANGHVIVAMCKLSKTRQMLTRQQQREQSTTVMLLIVTFVFAICNTLP---FLLNVSE 250

  Fly   282 DVIET--------------NTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRK--AFYKAVNC 330
            .:..|              |.|:.|::.:.:.|..        ::|...||.:|:  .|.....|
Worm   251 SIFPTLFQDESTRGLAYWLNDLSNLLVVLNSGTTF--------IIYFTFSEKYRQTLVFILKNGC 307

  Fly   331 S---SRYQNYTSDLPPPRKTSCARTSTTG 356
            .   |.|.|||:   ..|..|...:|.||
Worm   308 CATVSDYNNYTA---MSRTASMRISSETG 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	30/131 (23%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	56/296 (19%)
frpr-18	NP_504746.1	7tmA_FMRFamide_R-like	6..299	CDD:320109	64/315 (20%)
		TM helix 1	6..32	CDD:320109	8/20 (40%)
		TM helix 2	39..64	CDD:320109	6/24 (25%)
		TM helix 3	83..113	CDD:320109	5/29 (17%)
		TM helix 4	125..145	CDD:320109	7/27 (26%)
		TM helix 5	175..200	CDD:320109	4/26 (15%)
		TM helix 6	220..250	CDD:320109	8/32 (25%)
		TM helix 7	267..292	CDD:320109	5/32 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910