Protein Alignment AstA-R2 and ckr-2

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001367973.1
• Gene: ckr-2 / 175341
• WormBaseID: WBGene00021439
• Length: 603
• Species: Caenorhabditis elegans
• Alignment Length: 550
• Identity: 106/550 - (19%)
• Similarity: 189/550 - (34%)
• Gaps: 231/550 - (42%)

  Fly     5 TMLANISLN-ATRNEENITSFFTDEEWLAINGTLP-WIVGFFFGVIAITGFFGNLLVILVVVFNN 67
            |:.:|:|.. :|.::|.|..|         .||.. :.:...|.:|.:....||.:|::|::...
 Worm    34 TLNSNLSTTMSTVHQEEICRF---------RGTTENYTIAVTFFMIFLLSVVGNSVVLIVIIKQR 89

  Fly    68 NMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLM 132
            .|||.||:.::||||:|:|..::|:|.|....::..|.:|.:.|:.:.||..|...||.|||.::
 Worm    90 AMRSITNIYLMNLAASDMMLSVVCMPPTLVSMVMNCWMFGNYMCKILAYLQPVVVTASAYTLAVI 154

  Fly   133 SIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFT 197
            :.:|:.|:..|:.||:.:|.:.....|..:|::.:..::.:.|              .|...|::
 Worm   155 AFERYFAICKPLHSRIWQTRSHAYAMITLVWVIAIAANILMLF--------------MYEQQTYS 205

  Fly   198 TNDF----LGPR----TYQVTFFISSYLLPLMIISGLYMRMIMRL-------------------- 234
            :|.:    :.|.    .|||...:...::||::::|||..:|..|
 Worm   206 SNGYTCAPIHPPIYHFAYQVYMTVVLLVIPLVVMAGLYGNVITSLKSGIKLEIASVDPPLATATT 270

  Fly   235 ----------------------------------------------------------------- 234
                                                                             
 Worm   271 TGAKNLGSHSDSAHLLLNNVLVGSSQLARATSCIALNTFSCNNTTNPFSTLTPPPPIQQKNRSKP 335

  Fly   235 -----------------------------------------------WRQ--------------- 237
                                                           |.:
 Worm   336 QLLQLPGKIDNFEEFRLQCLSDCRSDGVLFPPPAIVASMTDEQKLSFWNKLSNKLTFSQQDKTVQ 400

  Fly   238 --GTGVRMS----------------KESQRGRKRVTRLVVVVVIAFASLWLPVQLILLL------ 278
              ..|.|.|                ::|...::||.::::||||.|...|.|..:..||
 Worm   401 HPNFGHRKSDTSICLENPSLRSTHTQKSAMAKQRVIKMLIVVVIIFFCCWTPSYIWWLLLIAGDS 465

  Fly   279 -KSLDV----IETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFY----KAVNCSSRY 334
             :||::    .:.||...|        |.|.|||.||:.|.||::.||.|.|    :..|....:
 Worm   466 FQSLNLSVWNSDINTFITL--------LTYISSCTNPITYCFLNKKFRNAVYATFGRKKNMRHHF 522

  Fly   335 Q----------NYTSDLPPPRKTSCARTST 354
            |          |||:...|.:..:.:.:||
 Worm   523 QKVYIPVNGGTNYTNKGEPRQIINRSVSST 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	87/468 (19%)
		TM helix 1	40..66	CDD:320224	6/25 (24%)
		TM helix 2	73..99	CDD:320224	11/25 (44%)
		TM helix 3	111..141	CDD:320224	11/29 (38%)
		TM helix 4	153..173	CDD:320224	2/19 (11%)
		TM helix 5	204..233	CDD:320224	10/32 (31%)
		TM helix 6	249..279	CDD:320224	11/36 (31%)
		TM helix 7	292..317	CDD:320224	10/24 (42%)
ckr-2	NP_001367973.1	7tmA_CCKR-like	61..508	CDD:320124	87/468 (19%)
		TM helix 1	62..88	CDD:320124	6/25 (24%)
		TM helix 2	95..121	CDD:320124	11/25 (44%)
		TM helix 3	133..163	CDD:320124	11/29 (38%)
		TM helix 4	177..195	CDD:320124	2/17 (12%)
		TM helix 5	220..245	CDD:320124	8/24 (33%)
		TM helix 6	430..460	CDD:320124	10/29 (34%)
		TM helix 7	476..501	CDD:320124	12/32 (38%)