DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and Galr3

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_056553.2	Gene:	Galr3 / 14429	MGIID:	1329003	Length:	370	Species:	Mus musculus

Alignment Length:	299	Identity:	96/299 - (32%)
Similarity:	149/299 - (49%)	Gaps:	21/299 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FGVIAITGFFGNLLVILVVVFN-----NNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYW 104
            |.:|.:.|..||.||:.|::..     ....|||:|.|:|||.|||.|::.|:||.|..|.:..|
Mouse    24 FALIFLLGMVGNGLVLAVLLQPGPSAWQEPGSTTDLFILNLAVADLCFILCCVPFQAAIYTLDAW 88

  Fly   105 PYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVV 169
            .:|.|.|::|..||.:|.:||.:||..:|:||:|||.||:|||.:||......|:..:|::..:.
Mouse    89 LFGAFVCKTVHLLIYLTMYASSFTLAAVSVDRYLAVRHPLRSRALRTPRNARAAVGLVWLLAALF 153

  Fly   170 SVPVAFTHDVVVDYDAKKNITYG---MCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYMRMI 231
            |.|....:..|         .||   :|.....| ...|...|..|.:.||||:.::|..|.|.:
Mouse   154 SAPYLSYYGTV---------RYGALELCVPAWED-ARRRALDVATFAAGYLLPVTVVSLAYGRTL 208

  Fly   232 MRLWRQ--GTGVRMSKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTLTKLVI 294
            ..||..  ..|...::..:|...|..|.::.|...:|..|.|...::|.........:..| ...
Mouse   209 CFLWAAVGPAGAAAAEARRRATGRAGRAMLTVAALYALCWGPHHALILCFWYGRFAFSPAT-YAC 272

  Fly   295 QVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNCSSR 333
            ::.:..|||::||:|||:|:..|.:||..|.:...|..|
Mouse   273 RLASHCLAYANSCLNPLVYSLASRHFRARFRRLWPCGHR 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	50/121 (41%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	86/267 (32%)
Galr3	NP_056553.2	7tm_4	24..>162	CDD:304433	54/137 (39%)
		7tm_1	34..291	CDD:278431	86/267 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	328..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	180	1.000	Domainoid score	I3486
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3654
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	1	1.000	-	-		FOG0000972
OrthoInspector	1	1.000	-	-		mtm8885
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1132
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.970