Protein Alignment AstA-R2 and CCR8

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_005192.1
• Gene: CCR8 / 1237
• HGNCID: 1609
• Length: 355
• Species: Homo sapiens
• Alignment Length: 344
• Identity: 95/344 - (27%)
• Similarity: 173/344 - (50%)
• Gaps: 45/344 - (13%)

  Fly    27 DEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILC 91
            |.|.:..||.|  ::..|:.::.:....||.|||||:|....:||.|::.::|||.:||:|| ..
Human    26 DAELIQTNGKL--LLAVFYCLLFVFSLLGNSLVILVLVVCKKLRSITDVYLLNLALSDLLFV-FS 87

  Fly    92 IPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITL 156
            .|| .|.|::..|.:|...|:.|.....:..::|::.:.|||:||:|||||.:.:..:||..:..
Human    88 FPF-QTYYLLDQWVFGTVMCKVVSGFYYIGFYSSMFFITLMSVDRYLAVVHAVYALKVRTIRMGT 151

  Fly   157 IAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFF------ISS 215
            ...:.:|:..::.::|      ::|.|..........|    ..|...:|.:...|      |..
Human   152 TLCLAVWLTAIMATIP------LLVFYQVASEDGVLQC----YSFYNQQTLKWKIFTNFKMNILG 206

  Fly   216 YLLPLMIISGLYMRMIMRLWRQGTGVRMSKESQRGRK-RVTRLVVVVVIAFASLWLPVQLILLLK 279
            .|:|..|....|::::.:|          |..|...| :..|||::||||....|:|..::|.|.
Human   207 LLIPFTIFMFCYIKILHQL----------KRCQNHNKTKAIRLVLIVVIASLLFWVPFNVVLFLT 261

  Fly   280 SL---DVIETNTLTKLVIQVT--AQTLAYSSSCINPLLYAFLSENFRK----AFYKAVNCSSRYQ 335
            ||   .:::..::::.:...|  .:.::::..|:||::|||:.|.|:|    .|.|  :||..:
Human   262 SLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIYAFVGEKFKKHLSEIFQK--SCSQIF- 323

  Fly   336 NYTSDLPPPRKTSCARTST 354
            ||.....|  :.||.::|:
Human   324 NYLGRQMP--RESCEKSSS 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	80/300 (27%)
		TM helix 1	40..66	CDD:320224	9/25 (36%)
		TM helix 2	73..99	CDD:320224	11/25 (44%)
		TM helix 3	111..141	CDD:320224	10/29 (34%)
		TM helix 4	153..173	CDD:320224	1/19 (5%)
		TM helix 5	204..233	CDD:320224	7/34 (21%)
		TM helix 6	249..279	CDD:320224	11/30 (37%)
		TM helix 7	292..317	CDD:320224	7/26 (27%)
CCR8	NP_005192.1	7tmA_CCR8	36..311	CDD:320315	81/298 (27%)
		TM helix 1	36..63	CDD:320315	10/28 (36%)
		TM helix 2	70..95	CDD:320315	11/26 (42%)
		TM helix 3	106..136	CDD:320315	10/29 (34%)
		TM helix 4	148..170	CDD:320315	2/27 (7%)
		TM helix 5	195..224	CDD:320315	6/28 (21%)
		TM helix 6	231..261	CDD:320315	11/29 (38%)
		TM helix 7	279..304	CDD:320315	7/24 (29%)