Protein Alignment AstA-R2 and CCR4

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_005499.1
• Gene: CCR4 / 1233
• HGNCID: 1605
• Length: 360
• Species: Homo sapiens
• Alignment Length: 388
• Identity: 103/388 - (26%)
• Similarity: 183/388 - (47%)
• Gaps: 73/388 - (18%)

  Fly     3 NTTMLANISLNATRNEENITSFFTDEEWLAINGTLPWIVGF-------FFGVIAITGFFGNLLVI 60
            |.|.:|:.:|     :|:|.|.:...|.:....|...|..|       .:.::.:.|..||.:|:
Human     2 NPTDIADTTL-----DESIYSNYYLYESIPKPCTKEGIKAFGELFLPPLYSLVFVFGLLGNSVVV 61

  Fly    61 LVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYY----WPYGRFWCRSVQYLIVVT 121
            ||:.....:||.|::.::|||.:||:|| ..:||..     ||    |.:|...|:.:.::.:|.
Human    62 LVLFKYKRLRSMTDVYLLNLAISDLLFV-FSLPFWG-----YYAADQWVFGLGLCKMISWMYLVG 120

  Fly   122 AFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVP-----VAFTHDVVV 181
            .::.|:.::||||||:||:||.:.|...||....:|..:..|.|.:..|:|     ..:|
Human   121 FYSGIFFVMLMSIDRYLAIVHAVFSLRARTLTYGVITSLATWSVAVFASLPGFLFSTCYT----- 180

  Fly   182 DYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMIISGLYM---RMIMRLWRQGTGVRM 243
                ::|.||....::.|.    .|::|...:...:|.|:|..|:.:   .||:|..:.....:.
Human   181 ----ERNHTYCKTKYSLNS----TTWKVLSSLEINILGLVIPLGIMLFCYSMIIRTLQHCKNEKK 237

  Fly   244 SKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKS---LDVIETNTLTKLV---IQVTAQTLA 302
            :|        ..:::..||:.|...|.|..::|.|::   |:|::..|..:.:   ||.| :|||
Human   238 NK--------AVKMIFAVVVLFLGFWTPYNIVLFLETLVELEVLQDCTFERYLDYAIQAT-ETLA 293

  Fly   303 YSSSCINPLLYAFLSENFRKAFYKAV-NCSSRY---------QNYTSDLPPPRKTSCARTSTT 355
            :...|:||::|.||.|.|||...:.. .|...:         |.|::|.|     |.:.|.:|
Human   294 FVHCCLNPIIYFFLGEKFRKYILQLFKTCRGLFVLCQYCGLLQIYSADTP-----SSSYTQST 351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	86/309 (28%)
		TM helix 1	40..66	CDD:320224	8/32 (25%)
		TM helix 2	73..99	CDD:320224	10/25 (40%)
		TM helix 3	111..141	CDD:320224	11/29 (38%)
		TM helix 4	153..173	CDD:320224	5/24 (21%)
		TM helix 5	204..233	CDD:320224	8/31 (26%)
		TM helix 6	249..279	CDD:320224	6/29 (21%)
		TM helix 7	292..317	CDD:320224	11/27 (41%)
CCR4	NP_005499.1	7tmA_Chemokine_R	40..315	CDD:341319	84/302 (28%)
		TM helix 1	40..67	CDD:341319	6/26 (23%)
		TM helix 2	74..99	CDD:341319	11/30 (37%)
		TM helix 3	110..140	CDD:341319	11/29 (38%)
		TM helix 4	154..174	CDD:341319	5/19 (26%)
		TM helix 5	199..228	CDD:341319	7/28 (25%)
		TM helix 6	235..265	CDD:341319	7/37 (19%)
		TM helix 7	283..308	CDD:341319	11/25 (44%)