Protein Alignment AstA-R2 and NPFFR2

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001138228.1
• Gene: NPFFR2 / 10886
• HGNCID: 4525
• Length: 423
• Species: Homo sapiens
• Alignment Length: 364
• Identity: 96/364 - (26%)
• Similarity: 181/364 - (49%)
• Gaps: 50/364 - (13%)

  Fly     2 ENTTMLANISLNATR----NEENIT--SFFTDEEWLAINGTLPWIVGFFFGVIAITGFFGNLLVI 60
            ||...:.|:  |.|:    ::.|||  :::..:..:|....:.:.:.||..::      ||.:|.
Human    14 ENWHPIWNV--NDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMM------GNTVVC 70

  Fly    61 LVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFAS 125
            .:|:.|.:|.:.|||.|:|||.:||:..|.|:|.|..|.::..||:|...|:....:..::..||
Human    71 FIVMRNKHMHTVTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAAS 135

  Fly   126 IYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNIT 190
            ::|||.:::|||..||:|.:.::  |.....:.|:.:|::.:.:..|.|    |::....:|
Human   136 VFTLVAIAVDRFQCVVYPFKPKL--TIKTAFVIIMIIWVLAITIMSPSA----VMLHVQEEK--- 191

  Fly   191 YGMCTFTTNDFLGP--------------RTYQVTFFISSYLLPLMIISGLYMRMIMRLWRQG--- 238
            |......:.:...|              :.|....|.:.||.||.:|..:|.|:.:.|:|..
Human   192 YYRVRLNSQNKTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPH 256

  Fly   239 TGVRMSKES----QRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTL--TKLVIQVT 297
            || |.::|.    .|.::::.:::::|.:.|...|||:..:::|.....:..|.|  ..:.|...
Human   257 TG-RKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPF 320

  Fly   298 AQTLAYSSSCINPLLYAFLSENFRKAFYKAVN---CSSR 333
            |..||:.:|.:||::|.|.:||||:.|.:|..   |..|
Human   321 AHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKR 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	83/307 (27%)
		TM helix 1	40..66	CDD:320224	6/25 (24%)
		TM helix 2	73..99	CDD:320224	13/25 (52%)
		TM helix 3	111..141	CDD:320224	9/29 (31%)
		TM helix 4	153..173	CDD:320224	2/19 (11%)
		TM helix 5	204..233	CDD:320224	10/42 (24%)
		TM helix 6	249..279	CDD:320224	6/29 (21%)
		TM helix 7	292..317	CDD:320224	9/24 (38%)
NPFFR2	NP_001138228.1	7tmA_NPFFR2	49..347	CDD:320646	83/313 (27%)
		TM helix 1	50..76	CDD:320646	6/31 (19%)
		TM helix 2	83..109	CDD:320646	13/25 (52%)
		TM helix 3	121..151	CDD:320646	9/29 (31%)
		TM helix 4	162..183	CDD:320646	4/24 (17%)
		TM helix 5	219..248	CDD:320646	9/28 (32%)
		TM helix 6	270..300	CDD:320646	6/29 (21%)
		TM helix 7	315..340	CDD:320646	9/24 (38%)