Protein Alignment AstA-R2 and LPAR6

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_005758.2
• Gene: LPAR6 / 10161
• HGNCID: 15520
• Length: 344
• Species: Homo sapiens
• Alignment Length: 315
• Identity: 79/315 - (25%)
• Similarity: 148/315 - (46%)
• Gaps: 36/315 - (11%)

  Fly    40 IVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYYW 104
            :.|..|.::.:.|...|.:.|.:.:....:|:.|...::|||.:||:|| ..:||....:....|
Human    19 LYGCMFSMVFVLGLISNCVAIYIFICVLKVRNETTTYMINLAMSDLLFV-FTLPFRIFYFTTRNW 82

  Fly   105 PYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLVV 169
            |:|...|:....|.....:.||..|..:|:|||||:|:|.:|:.:||:....|....:|:.|:..
Human    83 PFGDLLCKISVMLFYTNMYGSILFLTCISVDRFLAIVYPFKSKTLRTKRNAKIVCTGVWLTVIGG 147

  Fly   170 SVPVAF---THDVVVDYDAKKNITYGMCTFTTNDFLGPRTY--QVTFFIS--SYLLPLMI---IS 224
            |.|..|   ||       ::.|.....| |........:||  ::..||.  .:.:||::   .|
Human   148 SAPAVFVQSTH-------SQGNNASEAC-FENFPEATWKTYLSRIVIFIEIVGFFIPLILNVTCS 204

  Fly   225 GLYMRMIMRLWRQGTGVRMSKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETNTL 289
            .:.::.:.:      .|.:|: |:..:.:|.:::.|.:|.|...::|..:.|:|.||  :.|.|.
Human   205 SMVLKTLTK------PVTLSR-SKINKTKVLKMIFVHLIIFCFCFVPYNINLILYSL--VRTQTF 260

  Fly   290 TKLVIQVTAQT-------LAYSSSCINPLLYAFLSENFRKAFYKAVNCSSRYQNY 337
            ....:....:|       :|.|:.|.:|::|.|.|:..:.:. |..|.|.|..::
Human   261 VNCSVVAAVRTMYPITLCIAVSNCCFDPIVYYFTSDTIQNSI-KMKNWSVRRSDF 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	75/300 (25%)
		TM helix 1	40..66	CDD:320224	5/25 (20%)
		TM helix 2	73..99	CDD:320224	10/25 (40%)
		TM helix 3	111..141	CDD:320224	11/29 (38%)
		TM helix 4	153..173	CDD:320224	4/19 (21%)
		TM helix 5	204..233	CDD:320224	7/35 (20%)
		TM helix 6	249..279	CDD:320224	6/29 (21%)
		TM helix 7	292..317	CDD:320224	7/31 (23%)
LPAR6	NP_005758.2	7tmA_LPAR6_P2Y5	18..302	CDD:320284	75/300 (25%)
		TM helix 1	18..45	CDD:320284	5/25 (20%)
		TM helix 2	52..77	CDD:320284	10/25 (40%)
		TM helix 3	89..119	CDD:320284	11/29 (38%)
		TM helix 4	131..153	CDD:320284	5/21 (24%)
		TM helix 5	181..210	CDD:320284	5/28 (18%)
		TM helix 6	222..252	CDD:320284	6/29 (21%)
		TM helix 7	270..295	CDD:320284	7/24 (29%)