DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and galr3

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	XP_004913937.2	Gene:	galr3 / 100488248	XenbaseID:	XB-GENE-5872135	Length:	422	Species:	Xenopus tropicalis

Alignment Length:	313	Identity:	98/313 - (31%)
Similarity:	174/313 - (55%)	Gaps:	32/313 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 AINGTLP---WIVGFFFGVIAITGFFGNLLVILVVVFNNNMR-STTNLMIVNLAAADLMFVILCI 92
            :::..||   .||...|.:|...|..||.||:.|::.|...: :||||.|:||..|||.|::||:
Frog    46 SVSSELPPGGIIVPVVFSLIFALGTVGNGLVLAVLLRNGQTKYNTTNLFILNLGVADLCFILLCV 110

  Fly    93 PFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLI 157
            ||.||.|.:..|.:|.|.|::|.:.|.::.:||.:||..:|:||:||:.:|::||.:||....|.
Frog   111 PFQATIYTLDGWLFGAFLCKAVHFSIYLSMYASSFTLAAVSVDRYLAIRYPLKSRDLRTSRNALA 175

  Fly   158 AIVTLWIVVLVVSVP-VAFTHDVVVDY---------DAKKNITYGMCTFTTNDFLGPRTYQVTFF 212
            ||..:|.:.::.:.| :::.|.::.:.         |.::.|                 ..|:.|
Frog   176 AIGVIWALSILFAGPYLSYYHIILYNQVPICIPNWEDRRRKI-----------------MDVSTF 223

  Fly   213 ISSYLLPLMIISGLYMRMIMRLWRQGTGVRMSKESQRGRKRVTRLVVVVVIAFASLWLPVQLILL 277
            :..||||::|:...|.|.|..||.....|:.:.||::.:.:||:::::|.:.|...|||..|::|
Frog   224 VFGYLLPVLILGLSYARTICFLWTSVDPVKTASESRKAKHKVTKMIIIVAVLFCICWLPHHLVIL 288

  Fly   278 LKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNC 330
            .........|..| ...::.:..::|::||:||::||.:|::|||.|.:...|
Frog   289 CFWFGHFPFNKAT-YAFRLVSHCMSYANSCLNPIVYALISKHFRKRFKQVFTC 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	49/117 (42%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	83/268 (31%)
galr3	XP_004913937.2	7tmA_Gal2_Gal3_R	56..334	CDD:320225	94/295 (32%)
		TM helix 1	57..83	CDD:320225	10/25 (40%)
		TM helix 2	91..117	CDD:320225	16/25 (64%)
		TM helix 3	129..159	CDD:320225	12/29 (41%)
		TM helix 4	171..191	CDD:320225	4/19 (21%)
		TM helix 5	215..244	CDD:320225	11/45 (24%)
		TM helix 6	260..290	CDD:320225	9/29 (31%)
		TM helix 7	302..327	CDD:320225	7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3318
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3482
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	1	1.000	-	-		FOG0000972
OrthoInspector	1	1.000	-	-		mtm14084
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970