DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and kiss1r

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_001163985.1	Gene:	kiss1r / 100316929	XenbaseID:	XB-GENE-990075	Length:	366	Species:	Xenopus tropicalis

Alignment Length:	310	Identity:	97/310 - (31%)
Similarity:	159/310 - (51%)	Gaps:	39/310 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 WIVGFFFGVIAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTATDYMVYY 103
            |:|..||.::.:.|..||.|||.|:..:..||:.||..|.||||.|::|::.|:||||..|.:..
Frog    43 WLVPLFFAMLMLVGLTGNSLVIYVISKHKQMRTVTNFYIANLAATDIIFLVSCVPFTAALYPLPG 107

  Fly   104 WPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIAIVTLWIVVLV 168
            |.:|.|.|:.|.|:..|:..|:..||..||:||:...|:|::|...||..:.....|.:||...:
Frog   108 WIFGEFMCKFVNYIQQVSVQATCVTLTAMSVDRWYVTVYPLQSLRQRTPRVAAAVSVGIWIGSFI 172

  Fly   169 VSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTY----------QVTF----FISSYLLP 219
            ||:||...:.::..|                 :.||:.|          :..|    |:..||||
Frog   173 VSIPVPIYNQLIEGY-----------------WFGPQIYCSESFPSVSHEKAFILYNFLVVYLLP 220

  Fly   220 LMIISGLYMRMIMRLWRQGTG--------VRMSKESQRGRKRVTRLVVVVVIAFASLWLPVQLIL 276
            |:.|...|..|:.::.|....        ..:::.|:..|.:::|:|.|:|:.|...|.|:||.:
Frog   221 LITICICYSAMVYQMGRPSVEPVDNSYQVQLLAERSELMRTKISRMVAVIVLLFTICWGPIQLYI 285

  Fly   277 LLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYK 326
            |.::.............:::.|..::|::|.|||::|||:..||||||.|
Frog   286 LFQAFSPSFKRDYYTYKVKIWANCMSYTNSSINPIVYAFMGANFRKAFNK 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	44/116 (38%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	82/279 (29%)
kiss1r	NP_001163985.1	7tmA_KiSS1R	43..333	CDD:320223	94/306 (31%)
		TM helix 1	44..70	CDD:320223	10/25 (40%)
		TM helix 2	77..103	CDD:320223	14/25 (56%)
		TM helix 3	115..145	CDD:320223	11/29 (38%)
		TM helix 4	157..177	CDD:320223	5/19 (26%)
		TM helix 5	205..234	CDD:320223	10/28 (36%)
		TM helix 6	258..288	CDD:320223	11/29 (38%)
		TM helix 7	301..326	CDD:320223	9/24 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14084
Panther	1	1.100	-	-	O	PTHR24230
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.020