Protein Alignment AstA-R2 and adra2c

DIOPT Version :10

• Sequence 1: NP_524544.1
• Gene: AstA-R2 / 43393
• FlyBaseID: FBgn0039595
• Length: 357
• Species: Drosophila melanogaster
• Sequence 2: NP_001120375.1
• Gene: adra2c / 100145449
• XenbaseID: XB-GENE-5773399
• Length: 433
• Species: Xenopus tropicalis
• Alignment Length: 446
• Identity: 93/446 - (20%)
• Similarity: 170/446 - (38%)
• Gaps: 143/446 - (32%)

  Fly    18 EENITSFFTDEEWLAINGTLPWIVGFFFGVIAITGFF------GNLLVILVVVFNNNMRSTTNLM 76
            |.:.|:..|......:.|..|:.:...:.:.||.||.      ||:.|::.|:.:..:::..||.
 Frog     5 ENSTTTNSTPFPSSGVRGVWPYSMTSVWCLAAIVGFLIIFTIVGNVFVVIAVLTSRALKAPQNLF 69

  Fly    77 IVNLAAADLMFVILCIPFTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVV 141
            :|:||:||::...|.:||:..:.::.||.:|..||.....|.|:...:||..|..:|:||:.:|.
 Frog    70 LVSLASADILVAALVMPFSLANELMGYWYFGNVWCDIYLALDVLFCTSSIVHLCAISLDRYWSVT 134

  Fly   142 HPIRSRMMRTENITLIAIVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRT 206
            ..:...:.||.......|||:|::..|:|.|..    :.:|.|.:.:: |..|....:.:
 Frog   135 QAVEYNLKRTPRRIKGIIVTVWLISAVISFPPL----ISMDRDTEDDV-YPQCKLNDDTW----- 189

  Fly   207 YQVTFFISSYLLPLMIISGLYMRM--IMRL---------------------WRQGTGVRM----- 243
            |.::..|.|:..|.:|:..:|:|:  :.:|                     :.:||.|:|
 Frog   190 YILSSCIGSFFAPCIIMILVYIRIYQVAKLRTRTLSEKKPTRDGSSHTENGFSKGTTVKMPGDKE 254

  Fly   244 -------------------------------------------SKE------------------- 246
                                                       |||
 Frog   255 NGHCPPRPSPPKATDVEDLELEESSMSESKRRKSSSKEDNTDSSKERKCSKGNSFSKQSSRLSRT 319

  Fly   247 ------------------------SQRGRKRVTRLVVVVVIAFASLWLPVQLILLL-----KSLD 282
                                    ||...||.|.::.||:..|...|.|......|     ::.:
 Frog   320 SNKSMELFSSRKKKKRSSVSRRKLSQAREKRFTFVLAVVMGVFVVCWFPFFFSYSLYGICREACE 384

  Fly   283 VIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNCSSRYQNYT 338
            |.|  ||.|....:     .|.:|.:||::|...:::||::|.|.: |..|.:.:|
 Frog   385 VPE--TLFKFFFWI-----GYCNSSLNPVIYTIFNQDFRRSFKKII-CIGRRKTFT 432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_524544.1	7tmA_AstA_R_insect	39..324	CDD:320224	83/409 (20%)
		TM helix 1	40..66	CDD:320224	8/31 (26%)
		TM helix 2	73..99	CDD:320224	10/25 (40%)
		TM helix 3	111..141	CDD:320224	9/29 (31%)
		TM helix 4	153..173	CDD:320224	6/19 (32%)
		TM helix 5	204..233	CDD:320224	7/30 (23%)
		TM helix 6	249..279	CDD:320224	9/34 (26%)
		TM helix 7	292..317	CDD:320224	5/24 (21%)
adra2c	NP_001120375.1	7tmA_alpha2C_AR	32..419	CDD:320446	83/403 (21%)
		TM helix 1	33..59	CDD:320446	8/25 (32%)
		TM helix 2	66..92	CDD:320446	10/25 (40%)
		TM helix 3	104..134	CDD:320446	9/29 (31%)
		TM helix 4	146..169	CDD:320446	7/26 (27%)
		TM helix 5	187..216	CDD:320446	7/33 (21%)
		TM helix 6	346..376	CDD:320446	8/29 (28%)
		TM helix 7	387..412	CDD:320446	9/31 (29%)