DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and galr1

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_001107355.1	Gene:	galr1 / 100135180	XenbaseID:	XB-GENE-5797254	Length:	351	Species:	Xenopus tropicalis

Alignment Length:	333	Identity:	119/333 - (35%)
Similarity:	184/333 - (55%)	Gaps:	31/333 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 LAINGTLPWIVGFFFGVIAITGFFGNLLVILVVVFN--NNMRSTTNLMIVNLAAADLMFVILCIP 93
            :.|:..:..:|   ||:|...|..||.|||.|:..|  ...|||||:.|:||:.|||.:::.|||
Frog    33 IGIDNVITLVV---FGMIFALGVLGNSLVITVLARNKPGKPRSTTNIFILNLSIADLAYLLFCIP 94

  Fly    94 FTATDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRSRMMRTENITLIA 158
            |.:|.|::..|..|.|.|:.:.|...|:...||:||..||:||::|:||..||..:|.....|:.
Frog    95 FQSTVYVLPTWVLGAFICKFIHYFFTVSMLVSIFTLSAMSVDRYVAIVHSRRSSAIRVSRNALVG 159

  Fly   159 IVTLWIVVLVVSVPVAFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPLMII 223
            ::.:||:.:.::.|||:...:|.    |.|.|:  |..:..:....|.|.|..|:..|||||::|
Frog   160 VIVIWILSIAMASPVAYNQGLVY----KNNQTF--CWESWPNAQQKRIYVVCTFVFGYLLPLLLI 218

  Fly   224 SGLYMRMIMRLWRQGTGVR-MSKESQRGRKRVTRLVVVVVIAFASLWLPVQLILLLKSLDVIETN 287
            |..|.:::..|.::   :| |||:|:..:|:..:.|:|||:.|...|||..:|.|.     :|..
Frog   219 SFCYAKVLNHLHKK---LRNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHVIHLW-----VEYG 275

  Fly   288 ----TLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAFYKAVNC-------SSRYQNYTSDL 341
                |....|.::.|..||||:|.:||::|||||||||||:.:...|       .|..:...|.|
Frog   276 SFPLTQASFVFRIVAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCQIGCDSNQSDAKEIKSKL 340

  Fly   342 PPPRKTSC 349
            ..|..|:|
Frog   341 DTPPSTNC 348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	47/118 (40%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	95/264 (36%)
galr1	NP_001107355.1	7tmA_Gal1_R	38..316	CDD:320226	110/294 (37%)
		TM helix 1	39..65	CDD:320226	11/28 (39%)
		TM helix 2	74..100	CDD:320226	13/25 (52%)
		TM helix 3	112..142	CDD:320226	12/29 (41%)
		TM helix 4	154..174	CDD:320226	3/19 (16%)
		TM helix 5	199..228	CDD:320226	12/28 (43%)
		TM helix 6	242..272	CDD:320226	11/34 (32%)
		TM helix 7	284..309	CDD:320226	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I3318
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3482
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1294084at2759
OrthoFinder	1	1.000	-	-		FOG0000972
OrthoInspector	1	1.000	-	-		mtm14084
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.970