DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AstA-R2 and gpr84

DIOPT Version :9

Sequence 1:	NP_001263042.1	Gene:	AstA-R2 / 43393	FlyBaseID:	FBgn0039595	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	XP_021332416.1	Gene:	gpr84 / 100126017	ZFINID:	ZDB-GENE-070928-33	Length:	410	Species:	Danio rerio

Alignment Length:	384	Identity:	90/384 - (23%)
Similarity:	149/384 - (38%)	Gaps:	119/384 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 PWIVGF-FFGV-----IAITGFFGNLLVILVVVFNNNMRSTTNLMIVNLAAADLMFVILCIPFTA 96
            |.:.|: :|||     :.|.|..||:|.:|..|.:.|:|:..|::|||||.|||::..:..|.:.
Zfish    26 PSVEGYRYFGVLLGSAVTIVGTIGNILTVLAFVTDANLRTRFNVLIVNLAFADLLYCTILQPVSV 90

  Fly    97 TDYMVYYWPYGRFWCRSVQYLIVVTAFASIYTLVLMSIDRFLAVVHPIRS--RMMRTENITLIAI 159
            ..|:..:|..|..|||....|:.::...||.||.|:::.|:|.|.|...|  |::.::......:
Zfish    91 DSYLHLHWRGGATWCRMFGLLLFLSNSVSIITLCLIAMSRYLVVAHRTSSCARLLLSQRGVAALL 155

  Fly   160 VTLWIVVLVVSVPV----AFTHDVVVDYDAKKNITYGMCTFTTNDFLGPRTYQVTFFISSYLLPL 220
            ::.|::.|....|:    .|...|              ||.:.:...| |.|........:.|.|
Zfish   156 ISSWVLGLASFAPLWPVYVFAPQV--------------CTCSFHRTKG-RPYTTVLLFLYFFLGL 205

  Fly   221 MIISGLYMRMIMR----------LWR-------------QGT----GV----------------- 241
            ..: ||:..:|.|          .:|             :||    |:
Zfish   206 GFV-GLFYFLIYRKVSVAAKAFLKYRPSRRSSKRKQAEAEGTTDDSGISAGASTTQSCEISSDGA 269

  Fly   242 ---RMSKESQRGR--------------------------------------KRVTRLVVVVVIAF 265
               :..|::|.|:                                      |||||:...|.:.|
Zfish   270 VAEQHGKQAQEGQTTTQNATQHASSETTSKASPVVIQNTPAAANSGEDNEFKRVTRMCFTVFLCF 334

  Fly   266 ASLWLPVQLILLLKSLDVIETNTLTKLVIQVTAQTLAYSSSCINPLLYAFLSENFRKAF 324
            ...:.|..|      |:|.:.......||.:....|.:.:|||||||||.::..|.:|:
Zfish   335 VGCFAPFLL------LNVADKKNRAPQVIHMICANLTWLNSCINPLLYAAMNRQFNQAY 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AstA-R2	NP_001263042.1	7tm_4	47..>164	CDD:304433	38/123 (31%)
AstA-R2	NP_001263042.1	7tm_1	55..313	CDD:278431	78/348 (22%)
gpr84	XP_021332416.1	7tmA_GPR84-like	33..387	CDD:320338	87/375 (23%)
		TM helix 1	34..60	CDD:320338	10/25 (40%)
		TM helix 2	67..90	CDD:320338	10/22 (45%)
		TM helix 3	105..135	CDD:320338	10/29 (34%)
		TM helix 4	151..169	CDD:320338	2/17 (12%)
		TM helix 5	189..214	CDD:320338	7/26 (27%)
		TM helix 6	318..348	CDD:320338	11/35 (31%)
		TM helix 7	355..380	CDD:320338	12/24 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24230
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100