Protein Alignment htt and T28B8.3

DIOPT Version :9

• Sequence 1: NP_001263041.1
• Gene: htt / 43392
• FlyBaseID: FBgn0027655
• Length: 3583
• Species: Drosophila melanogaster
• Sequence 2: NP_001364595.1
• Gene: T28B8.3 / 189032
• WormBaseID: WBGene00012114
• Length: 1889
• Species: Caenorhabditis elegans
• Alignment Length: 1725
• Identity: 300/1725 - (17%)
• Similarity: 506/1725 - (29%)
• Gaps: 675/1725 - (39%)

  Fly  1296 SKWPPMDASSVC--HSVRDAEGEDIVCTYEAQFLAELLHLLGDDDARVREHAACCLCRFIMQTAR 1358
            |.:|.||.|:..  |..:.:..:.::|            ||......:.||....|...|...:.
 Worm   541 SSFPLMDFSAAIKFHEEKMSNDDRLIC------------LLSKRVPSLVEHTLEKLLEVITCLSV 593

  Fly  1359 QDPSQDQGAGG----------GGGDDIEGNG----------NVNVETQQTNFNLLWD------FF 1397
            :.|:.....||          |..:.|..||          .||...::..|:.|:|      |.
 Worm   594 EAPNTSDSTGGVSLSLEYQKHGEDETIFKNGFSRLISVIFDRVNDTMRKRLFDRLFDYISTSEFT 658

  Fly  1398 DYRIFGSMSVTLRNLFRASSTIVPPLAEL----------DALATSNSAPSYPDTGSTSGSSTSTS 1452
            :|.....:|..:.|..|.|.......||.          |.:.||.:.|.         |.....
 Worm   659 NYLATDILSSLIFNAVRTSGDAFRHYAEFILKKLKLLITDEVRTSKTPPV---------SVLFYC 714

  Fly  1453 ASSGGSAAAVSAASAYFEASYGIGIAEGHVFALASASQRQIAQEEKVLAKVLYRLTNKLMTLNDK 1517
            |.||          ..|.|:..|.:...|:|.              .:.::.....||.:.   |
 Worm   715 ALSG----------PCFAANRTIVLDNEHIFF--------------EIIEIFLNCANKTIF---K 752

  Fly  1518 NVQFGIIYALRLLL----------RHFNFVDYQQVWLEFNFVEICISY----AYYNNATAADLGC 1568
            ....|:...|..||          .|..|.:....|....|...|:.|    .:::....||:.|
 Worm   753 CGTIGVSTLLHNLLNITTNFPVKTEHNQFSEPFSEWNPIEFWAKCVHYKDTVVHWSIPAKADISC 817

  Fly  1569 QNDLID-----VMGKLMAGAM-LSSGEPNTAHLDFLLRHSVKMLNIYYHLVTNQRP--------- 1618
            ...:.:     .:.|||.... ..|....|.||.:          :.::|.|.:.|
 Worm   818 VERIANKFFFPYIQKLMTEVQDRDSFRRITEHLHY----------VVFNLPTLKYPTNVQWLRNS 872

  Fly  1619 ------PTAGSQSGSS-----SSKQPKSELFAREQPAATLQALGYFAGDYVYMKLYNILRGANDS 1672
                  |.|.|..|:|     ..|.|.                    |:.|...:.:::     .
 Worm   873 STPFCLPIASSSLGASCVLEYELKGPN--------------------GENVCEMVVSMI-----E 912

  Fly  1673 YKITINQEAGSLL-IC-LLKTCLHAVSLCLEGMASASPPELKLIEEILHYLTRLINYAPA----- 1730
            :.||..|:..||: || :.||||.......:.:.|...|...|:.:.::     :|...|
 Worm   913 HVITKTQDPTSLINICSIAKTCLRVFEKPKDDITSLLDPTSALLVDSIY-----LNIVKASQHTI 972

  Fly  1731 ECVACLRQLLKYLF-------AQNYASQV---RLQPSAIGGNGSEIGHHAAFMRPYFAAKGRGHG 1785
            :.:|.::.:...|:       |.::..::   .|:.|               :..||..:.|..|
 Worm   973 DHIAFIKHIQTQLYHRCEIRDATDFDERILKCLLELS---------------VNDYFTVQKRASG 1022

  Fly  1786 ASSTLLPTINSKPAVAVGSQRGAPTDARQPIDAGPLQDMGMLFVHGLQPPTPPAGDCVRLIKLFE 1850
            ...|:             ||.                                    :|...|..
 Worm  1023 YLKTI-------------SQN------------------------------------IRCRHLLI 1038

  Fly  1851 PMVIYCLT--LFMKSNALVQAPILRLLSQLLDLNVTYSILDSKNVIFDQVL--SNMDLIEGGIDR 1911
            |.|:..||  ..:..|.|..|..|.|..:.:.| ||..|   :.:|:|.||  ..||.:|   .|
 Worm  1039 PRVVEILTDAKLVNKNRLAGAMDLTLKLKWIKL-VTPRI---RLIIWDAVLRIKVMDNVE---IR 1096

  Fly  1912 NAFIMV---------PPMLRFLVQLTHKSDRQLITIPKIISITNNLLANGSVRVVALLALKTLSY 1967
            ..|..:         .|:.|...:.||..                  .|..|.|||||.:|..|.
 Worm  1097 GRFEAIRKELKNFWREPIYRLATRETHDE------------------RNKKVAVVALLLIKPSSD 1143

  Fly  1968 ELFFMHSQLEEALDTEGHNSGRDACQSPLSAAPTPETREALLAQRRELDTQREVVLGMLEKFIEA 2032
            ...|:                               |.|||..|   .||           :.:.
 Worm  1144 WTPFL-------------------------------TEEALKIQ---TDT-----------WFDY 1163

  Fly  2033 RPSQQVLALLL---LFERSVQQLDTPPYRSAQDADAVYGTLCRGLCSRQWRLHNAGDLRLLESCF 2094
            ......|.|.|   ||:..:|..:....|.......:|........|:..||       |||..|
 Worm  1164 EKLSHTLRLKLVDNLFKNHIQNKNHHHTRGKLARSMIYAAQMEACDSKTIRL-------LLEQLF 1221

  Fly  2095 ------RNNGNHVLA------DSKRFLQLLQ--------LFIEQGVGNFGDLALAMVMLSNVILK 2139
                  ||.....||      ..|...:.::        :.:|:|:                  :
 Worm  1222 DEHYTSRNEARETLAHWLKENKQKTVREKIKPPKRVDHGVKLERGI------------------R 1268

  Fly  2140 TEEIYLVNHIKLYLKNNPTAERRL-QALMPSSPSAAPHWQDEAPSTSSAAAAARAAAASFSAGRS 2203
            .:.::||..    .:|.|..|::. :.:.......|..|.:     |.:....|      |.|:.
 Worm  1269 EDNLWLVYD----SENLPNTEQKWNEIVFVEKEKGACRWPE-----SISVVRKR------SHGQP 1318

  Fly  2204 SISEINYFAKVLCEKLLACLEVLLGLEPSSSSHAYCQLTGRFMDALLNVCCRSRHKDALQSVFRL 2268
                                     |||.:.|.:...:.|||
 Worm  1319 -------------------------LEPKNPSESDKMIIGRF----------------------- 1335

  Fly  2269 VLAESEFLCKYYSLLLMSAAGLVGSYLLDAVLLACLRLVLAMRLEEP----VALLEQA------A 2323
              ::|:|:.|.::                      .||:.....|.|    ..:|:..      .
 Worm  1336 --SQSKFISKLFN----------------------FRLIEKEDYENPNDKFYRILKYVIRNYPDT 1376

  Fly  2324 QLPLKTNLQRALLREVCRASAGCDWSAQQVRRLFEGRYLNFLIADHLEFICELCQERPECGSLLQ 2388
            ::|||                                    |:::||:.   |.:.:.:...||.
 Worm  1377 KIPLK------------------------------------LMSEHLKL---LMKSKKKNEQLLA 1402

  Fly  2389 VALFRNAHRLSRQSVRIVLRLLGRLCEPAEREASGDVGSDADPTLQAMQLLSRLHQLYEGERSLQ 2453
            ..:|          :.|||.:..|.....: |...|:.:..:..|..:.:        |.|.:..
 Worm  1403 AEIF----------IGIVLGIKHRSFFELD-EFWNDINTCLNQFLDILTI--------EAEEAWS 1448

  Fly  2454 LPIERMARRLSAQSGQPARNVIYERLVEGDLAGGEDQDALRTLLLKDLECRQDNETATPSRII-- 2516
            :.:|.:....|     ..|.|.:  |:||.:.|..    :.||.         ||.....||.
 Worm  1449 IAMETILDPTS-----DLRRVWW--LIEGMIDGAR----MATLA---------NEFQLAFRITSI 1493

  Fly  2517 -DESWLFAQLIKFATQHADAPQQQKQLMLLLLEIQSEPKLQRLLRSLGTEHEA-------KLLRH 2573
             ...|.:.|:.|.|:..|....|      |.|.......:..:..|.....||       .:...
 Worm  1494 QSNCWRYGQISKRASDIAWTKLQ------LALTDSLRNAISEVFYSCSEAREASSNATLINIPSR 1552

  Fly  2574 AIAGSLAAMMSAFRQKCIQHAPHINYMQPTPLARVSCALLMSRVASTEATKCRNPPTG------- 2631
            .|..||..::    .|.|...|.:.:|:...:.|.|.:.|           ..|||||
 Worm  1553 FIPDSLDTII----HKIIDKIPDLKFMEDQKIIRASLSHL-----------DLNPPTGKMSRRRS 1602

  Fly  2632 -----EQLDVARAVGALMACIRNAEQTALIYIDARLMEKFVVEHL---------LRREHLPQLLA 2682
                 |.:.|: .:..:...:.|..|:...:   |::.:.:.:|.         :..:.||:|:.
 Worm  1603 SAIDLEDIKVS-GMDTIYTRMHNNFQSMTYF---RVLLQTITQHYGSSTKSWSPILVKLLPKLME 1663

  Fly  2683 Y-------------------------------LGWLAGA-AKQIL-AMPTRQESEQDALGVLLAT 2714
            |                               :.|::.. ..:|| |:.|...|  ::..|.||.
 Worm  1664 YANEDDYDLSEETYRDVDITQNSALIIHDYMSVSWISHMFLDEILKALGTTFHS--NSWHVRLAV 1726

  Fly  2715 VNTLLQQPRVWRELNASSDPSLRCELLDLL------------DSVARCILQ----DTIFYRRHRR 2763
            :..:  |..|:..:...|..|.|.::..||            ...|:|:|.    ..|.:...:.
 Worm  1727 IKFV--QAAVYSNIFPMSQQSRRDDIEKLLFRAVYDREISVRKEAAKCLLLFIHCSYIQFSDQKI 1789

  Fly  2764 DRNKAKGPAPQAIFLAKLIETQIEIESLASGRVLA 2798
            |:            ||.:::::.|:|:.|.|..||
 Worm  1790 DK------------LANILQSETELEARAHGASLA 1812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htt	NP_001263041.1	DUF3652	2726..2757	CDD:289166	8/46 (17%)
T28B8.3	NP_001364595.1	BLM10_mid	325..860	CDD:406818	70/376 (19%)
		HEAT repeat	1707..1739	CDD:293787	10/35 (29%)
		HEAT repeat	1749..1778	CDD:293787	5/28 (18%)
		HEAT repeat	1787..1815	CDD:293787	9/38 (24%)
		DUF3437	1804..1888	CDD:403208	4/9 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D5555at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010