Protein Alignment htt and Htt

DIOPT Version :9

• Sequence 1: NP_001263041.1
• Gene: htt / 43392
• FlyBaseID: FBgn0027655
• Length: 3583
• Species: Drosophila melanogaster
• Sequence 2: NP_034544.1
• Gene: Htt / 15194
• MGIID: 96067
• Length: 3120
• Species: Mus musculus
• Alignment Length: 3999
• Identity: 809/3999 - (20%)
• Similarity: 1356/3999 - (33%)
• Gaps: 1392/3999 - (34%)

  Fly    20 RNTECSQKQKITCFQQIAECIMSPSLAGHINYAAHCGTATNVLLLFCEDVDSVVRMSAEENLNKI 84
            :....::|.::.....|.|.|::.||.....:....|.|..:.||..:|.:|.|||.|:|.|||:
Mouse    70 KELSATKKDRVNHCLTICENIVAQSLRNSPEFQKLLGIAMELFLLCSDDAESDVRMVADECLNKV 134

  Fly    85 LRSLEKTRVSRILMDLYGEIKRNGNQRSLRICLNLFSYYAPQIKEKHIKWYAVRLLQCMTTISQR 149
            :::|..:.:.|:.::||.|||:||..||||..|..|:..|..::.:..:.|.|.||.|:|..|:|
Mouse   135 IKALMDSNLPRLQLELYKEIKKNGAPRSLRAALWRFAELAHLVRPQKCRPYLVNLLPCLTRTSKR 199

  Fly   150 KETLLQETLCDFVKHFSRHIQQGLSDSESCKLFETFLDQISSDCAVKRRCSAQNCMSLIENARNR 214
            .|..:||||...|...........:|:|...|.:.|:..:.|.....||.:|.:.:|:.:::|..
Mouse   200 PEESVQETLAAAVPKIMASFGNFANDNEIKVLLKAFIANLKSSSPTVRRTAAGSAVSICQHSRRT 264

  Fly   215 SLMARHGVNKVMELLLTDQQANS---VLGALGLLRLLLPQLIRGYPGDSHEDSESLAGKKQQQQQ 276
            .......:|.::.||:..::.:|   :||.|..||.|:|.|.:.....|.:.|..:..|:.:...
Mouse   265 QYFYNWLLNVLLGLLVPMEEEHSTLLILGVLLTLRCLVPLLQQQVKDTSLKGSFGVTRKEMEVSP 329

  Fly   277 TTTSDCRQIIEIYDYCLHLLSTQHTANHAIINATLEVIN--------GILQAVDAASDGQCSQSL 333
            :|    .|::::|:..||  .||| .:|.::...||::.        .:|||:....      .|
Mouse   330 ST----EQLVQVYELTLH--HTQH-QDHNVVTGALELLQQLFRTPPPELLQALTTPG------GL 381

  Fly   334 GQ---------------SLRQLLCNQQLQHNEYLRRRKSLKNQIFQLKNYEVATSQHQLEDEDEN 383
            ||               |:.:||.......:..|.|::         |...:...:..|||:.|:
Mouse   382 GQLTLVQEEARGRGRSGSIVELLAGGGSSCSPVLSRKQ---------KGKVLLGEEEALEDDSES 437

  Fly   384 -EDVDELVVGATAMQMKKNSNAKLQQAKCREQQQHQHQQQLEVDNSSLGI----NAGEDAPTEAP 443
             .||..   .|.|..:|.....:|.                    :|.|:    :.|.|..||.|
Mouse   438 RSDVSS---SAFAASVKSEIGGELA--------------------ASSGVSTPGSVGHDIITEQP 479

  Fly   444 SSVADEGGEPESTKLR-CHIRNAARSISECVASDEDKQGQGHRQQRDEDGVVVAEDDDDDDDDDD 507
            .|  ....:.:|..|. |.:.:||                                        .
Mouse   480 RS--QHTLQADSVDLSGCDLTSAA----------------------------------------T 502

  Fly   508 DDDDMELLSAECDDFTTL-----SQLNEQQQALSAALKLPTTTAASSGGAATSQDDKLIDVDADV 567
            |.|:.::||.....|:.:     ..||:..||.|.......||......|.|..|...|.:|
Mouse   503 DGDEEDILSHSSSQFSAVPSDPAMDLNDGTQASSPISDSSQTTTEGPDSAVTPSDSSEIVLD--- 564

  Fly   568 GGLPKPQHQSSLQNLLAGSDDKSQHLSDIDNESFNSIDFDAEITIAGSKEQQQQHPPADDSVESG 632
                             |:|  ||:|.                       .|...|..||  |.|
Mouse   565 -----------------GAD--SQYLG-----------------------MQIGQPQEDD--EEG 585

  Fly   633 DATAIGTFFNNLLSHSNAASESVSKLFRQSSGSKSTPSKSASTPAPADKSDAISAASLTLSLTSL 697
            .|..:              |..||.:||.|                   |.|:..|.|   |..:
Mouse   586 AAGVL--------------SGEVSDVFRNS-------------------SLALQQAHL---LERM 614

  Fly   698 ASSNLEPPERQPLIAETPTPVEDSCSITASHTASTALMMDAPAVEVA-ASKPETPQLR-----GT 756
            ..|      |||         .|| ||....|..          ||| ||.||:...|     |.
Mouse   615 GHS------RQP---------SDS-SIDKYVTRD----------EVAEASDPESKPCRIKGDIGQ 653

  Fly   757 PNANPFLVENSPLRQTVVGRALITVKIGSILEQSLVYYTARLVAARFLLSGQAAGLQPDSISRVS 821
            ||.:    :::||                       .:..||::|.|||:|:...|.||...|||
Mouse   654 PNDD----DSAPL-----------------------VHCVRLLSASFLLTGEKKALVPDRDVRVS 691

  Fly   822 IKSLSLAVIAQCVRLAPKILQLSLEISEQELQLLEEATSQIGSGDSTQVSSPQSSDNSQVGGEKP 886
            :|:|:|:.|...|.|.|                 |...|::                     .|.
Mouse   692 VKALALSCIGAAVALHP-----------------ESFFSRL---------------------YKV 718

  Fly   887 PLDSSLVPTSLEENLLLLDIKDDHFGPSTCPAYLQSATPTLSRSADASVLLLEGGTTSSRSAKKS 951
            ||
Mouse   719 PL--------------------------------------------------------------- 720

  Fly   952 EEMLSKSEIIESSYRPTVAVEDVPPLSMPPRPPKRTKSTRSRVGVLGTSSTTESSSPQSRQKLSD 1016
                                                             :||||:   ..|.:||
Mouse   721 -------------------------------------------------NTTEST---EEQYVSD 733

  Fly  1017 ILLFHDHCDPILRGGVQQVVGNFLQSSGAGLFLDLQRGLGLQHLLAILLKGFEDEIHTVVIQALN 1081
            ||.:.||.||.:||....:.|..:.|..:...|.:...||              .|.|:.....:
Mouse   734 ILNYIDHGDPQVRGATAILCGTLVYSILSRSRLRVGDWLG--------------NIRTLTGNTFS 784

  Fly  1082 AFDKIFPNVVSKYLTEPPCHYHAHQQQQQQQKEQQQQEQDNQKLEQDLQRHSSGQQKRSGQAQTF 1146
            ..|.| |.:                     ||..:.:.....||.....||
Mouse   785 LVDCI-PLL---------------------QKTLKDESSVTCKLACTAVRH-------------- 813

  Fly  1147 GQQTFAKDQDNALSSQRQQQRRPNDAGTCANSSATDNDELLAALLNDFQLQSTGMRQQPKNNSTD 1211
                                        |..|       |.::..:|..||
Mouse   814 ----------------------------CVLS-------LCSSSYSDLGLQ-------------- 829

  Fly  1212 TGQSGNEPDLEPNPNAAVEPFCVFAISPKLLLSKLRLCHHNKYWLVQNKYAEVISNLNYVLLRSY 1276
                                         ||:..|.| .::.||||:.:..:.::.:::.|:...
Mouse   830 -----------------------------LLIDMLPL-KNSSYWLVRTELLDTLAEIDFRLVSFL 864

  Fly  1277 YANFRCAIDNKNSGARKQDSKWPPMDASSVCHSVRDAEGEDIVCTYEAQFLAELLHLLGDDDARV 1341
            .|.                       |.|:........|  .:...|......:::||||:|.||
Mouse   865 EAK-----------------------AESLHRGAHHYTG--FLKLQERVLNNVVIYLLGDEDPRV 904

  Fly  1342 REHAACCLCRFIMQTARQDPSQDQGAGGGGGDDIEGNGNVNVETQQTNFNLLWDFFDYRIFGSMS 1406
            |..||..|.|.:       |........|..|.:     |.|...|:                 |
Mouse   905 RHVAATSLTRLV-------PKLFYKCDQGQADPV-----VAVARDQS-----------------S 940

  Fly  1407 VTLRNLFRASSTIVPPLAELDALATSNSAPSYPDTGSTSGSSTSTSASSGGSAAAVSAASAYFEA 1471
            |.|:.|...:.   ||                                            ::|..
Mouse   941 VYLKLLMHETQ---PP--------------------------------------------SHFSV 958

  Fly  1472 SYGIGIAEGHVFALASASQRQIAQEEKVLAKVLYRLTNKLMTLNDKNVQFGIIYALRLLLRHFNF 1536
            |....|..|:.. |.|.:.   ...|..|::|:..::::|:|...:.:.||...||.||...|..
Mouse   959 STITRIYRGYSL-LPSITD---VTMENNLSRVVAAVSHELITSTTRALTFGCCEALCLLSAAFPV 1019

  Fly  1537 VDYQQVWL-------------------EFNFVEICISYAYYNNATAADLGCQNDLIDVMGKLMA- 1581
            ..:...|.                   ..:.:...:|.|::    ..||....|.:.:.|.|:|
Mouse  1020 CTWSLGWHCGVPPLSASDESRKSCTVGMASMILTLLSSAWF----PLDLSAHQDALILAGNLLAA 1080

  Fly  1582 -------GAMLSSGEPNTAH------------------LDFLLRHSVKMLNIYYHLVTNQRPPTA 1621
                   .:..|..|.|:|.                  ::.|..|.:|::||..|::.:..|..|
Mouse  1081 SAPKSLRSSWTSEEEANSAATRQEEIWPALGDRTLVPLVEQLFSHLLKVINICAHVLDDVTPGPA 1145

  Fly  1622 --------------------------GSQSGSSSSKQPKSELFAREQ--------PAATLQALGY 1652
                                      |.|:.:..|.:...|..|..:        .|:...:||.
Mouse  1146 IKAALPSLTNPPSLSPIRRKGKEKEPGEQASTPMSPKKVGEASAASRQSDTSGPVTASKSSSLGS 1210

  Fly  1653 FAGDYVYMKLYNILRGANDSYKITIN-QEAGSLLICLLKTCLHAVSLCLEGMASASPPEL-KLIE 1715
            |.....|:||:::|:..:.:||:|:: |.:.......|::.|..:|..||   .|:..:: |.:|
Mouse  1211 FYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILE---LATLQDIGKCVE 1272

  Fly  1716 EILHYLTRLINYAPAECVACLRQLLKYLFAQNYASQ---VRLQPSAIGGNGSEIG--------HH 1769
            |:|.||....:..|.....|::||||.||..|.|||   :...||........:|        :|
Mouse  1273 EVLGYLKSCFSREPMMATVCVQQLLKTLFGTNLASQFDGLSSNPSKSQCRAQRLGSSSVRPGLYH 1337

  Fly  1770 AAFMRPYFAAKGRGHGASSTLLPTINSKPAVAVGSQRGAPTDARQPIDAG----PLQDMGMLFVH 1830
            ..||.||                 .:...|:|..|.|.. ..|.|..||.    .||.:......
Mouse  1338 YCFMAPY-----------------THFTQALADASLRNM-VQAEQERDASGWFDVLQKVSAQLKT 1384

  Fly  1831 GLQPPTPPAGDCVRL---IKLFEPMVIYCLTLFMKSNAL-VQAPILRLLSQLLDLNVTYSILDSK 1891
            .|...|....|...:   |:||||:||..|..:..:.:: :|..:|.||:||:.|.|.|.:|||.
Mouse  1385 NLTSVTKNRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCLLDSD 1449

  Fly  1892 NVIFDQVLSNMDLIEGGIDRNAFIMVPPMLRFLVQLTHK--SDRQLITIPKIISITNNLLANGSV 1954
            .|....||...:.||.|..|.:..::|.:..|||.|:::  ..:|:|.|||||.:.:.::|:|..
Mouse  1450 QVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRK 1514

  Fly  1955 RVV-ALLALKTLSYELFFMHSQLEEALDTEGHNSGRDACQSPLSAAPTPETREALLAQRRELDTQ 2018
            .|. |:.||:.:.::||.:..       |...::|                        :||:||
Mouse  1515 AVTHAIPALQPIVHDLFVLRG-------TNKADAG------------------------KELETQ 1548

  Fly  2019 REVVLGMLEKFIEARPSQQVLALLLLFERSVQQLDTPPYR--SAQDADAVYGTLCR--------- 2072
            :|||:.||.:.|:   ..|||.:.:|..:...:.:...::  |.|.||.:...|.:
Mouse  1549 KEVVVSMLLRLIQ---YHQVLEMFILVLQQCHKENEDKWKRLSRQVADIILPMLAKQQMHIDSHE 1610

  Fly  2073 --GLCSRQWRLHNAGDLR----LLESCFRNNGNHVLADSKRFLQLLQLFIEQGVGNFGDLALAMV 2131
              |:.:..:.:.....||    ||.|.|      :...:...:..:||:|.      |.||:..|
Mouse  1611 ALGVLNTLFEILAPSSLRPVDMLLRSMF------ITPSTMASVSTVQLWIS------GILAILRV 1663

  Fly  2132 MLSNVILKTEEIYLVNHIKLYLKNNPTAERRLQALMPSSPSAAPHWQDEAPSTSSAAAAARAAAA 2196
            ::|.   .||:|.|.               |:|.|     |.:||....................
Mouse  1664 LISQ---STEDIVLC---------------RIQEL-----SFSPHLLSCPVINRLRGGGGNVTLG 1705

  Fly  2197 SFSAGRSSISEINYFAKVLCEKLLACLEVL----LGLEPSSSSHA-YCQLTGRFMDALLNVCCRS 2256
            ..|.|:......:.|::.|.:.:...||.:    |.::.|...|. |||..|..:..|:::
Mouse  1706 ECSEGKQKSLPEDTFSRFLLQLVGILLEDIVTKQLKVDMSEQQHTFYCQELGTLLMCLIHI---- 1766

  Fly  2257 RHKDALQSVFRLVLAESEFLCKYYSLLLMSAAGLVGS-YLLDA---------------VLLACLR 2305
                ....:||.:.|.        :..|.::.|..|| |.|::               |||.|..
Mouse  1767 ----FKSGMFRRITAA--------ATRLFTSDGCEGSFYTLESLNARVRSMVPTHPALVLLWCQI 1819

  Fly  2306 LVLAMRLE----------------------EPVALLEQ-----AAQLPLKTNLQRALLREVCRAS 2343
            |:|....:                      .|....|:     ||||.:..       ||:.|..
Mouse  1820 LLLINHTDHRWWAEVQQTPKRHSLSCTKSLNPQKSGEEEDSGSAAQLGMCN-------REIVRRG 1877

  Fly  2344 A---GCDWSAQQVRRLFEGRYLNFLIADHLEFICELCQERPECGSLLQVALFRNA-HRLSRQSVR 2404
            |   .||:..|   .|.:..:|.:||.:|::.:..|..|.|       |..|.:| ||.|..|..
Mouse  1878 ALILFCDYVCQ---NLHDSEHLTWLIVNHIQDLISLSHEPP-------VQDFISAIHRNSAASGL 1932

  Fly  2405 IVLRLLGRLCEPAEREASGDVGSDADPTL--QAMQLLSRLHQLYEG-------ERSLQLPIERMA 2460
            .:..:..| ||           :.:.||.  :.:|.|..:|....|       :|.|..|...:|
Mouse  1933 FIQAIQSR-CE-----------NLSTPTTLKKTLQCLEGIHLSQSGAVLTLYVDRLLGTPFRALA 1985

  Fly  2461 RRLS-------------------AQSGQPARNVIYERLVEGDLAGGEDQDALRTLLLK-DLECRQ 2505
            |.:.                   ||..:...|.|.|.|....||  :....|.:||.: .|...|
Mouse  1986 RMVDTLACRRVEMLLAANLQSSMAQLPEEELNRIQEHLQNSGLA--QRHQRLYSLLDRFRLSTVQ 2048

  Fly  2506 DN--------------------ETATPSRIIDESWLFAQLIKFA--TQHADAPQQQKQLMLLLLE 2548
            |:                    ||.:|    |:.| :.||::..  |:...|..:..:   |:..
Mouse  2049 DSLSPLPPVTSHPLDGDGHTSLETVSP----DKDW-YLQLVRSQCWTRSDSALLEGAE---LVNR 2105

  Fly  2549 IQSEPKLQRLLRSLGTEHEAKLLRHAIAGSLAAMMSAFRQKCIQHAPHINYMQPTPLARVSCALL 2613
            |.:|.....::.|   |....||...::..::.:.:.               |.:||...:..::
Mouse  2106 IPAEDMNDFMMSS---EFNLSLLAPCLSLGMSEIANG---------------QKSPLFEAARGVI 2152

  Fly  2614 MSRVASTEATKCRNPPTGEQLDVARAVGALMACIRNAEQTAL----------------IYIDARL 2662
            ::||.|..          :||.   ||..:.......|.||.                :.|.||.
Mouse  2153 LNRVTSVV----------QQLP---AVHQVFQPFLPIEPTAYWNKLNDLLGDTTSYQSLTILARA 2204

  Fly  2663 MEKFVV------EHLLRREHLPQLLAYLGWLAGAAKQILAMPTRQESEQDALGVLLATVNTL--- 2718
            :.:::|      .||    |||                      .|.|.|.:..::.||..|
Mouse  2205 LAQYLVVLSKVPAHL----HLP----------------------PEKEGDTVKFVVMTVEALSWH 2243

  Fly  2719 ----------------------LQQPRVWRELNASSDPSLRCELLDLLDSVARCILQDTIFYRRH 2761
                                  ||.|.:|..|::....:..|.|:..:    |.||:........
Mouse  2244 LIHEQIPLSLDLQAGLDCCCLALQVPGLWGVLSSPEYVTHACSLIHCV----RFILEAIAVQPGD 2304

  Fly  2762 RRDRNKAKGPAPQAIFLAKLIETQIEIESL-----ASGRVLAGVEEARLQFA-----GQDLARFQ 2816
            :....:::...|:|:   :..|...:|::|     |...|...||..:...|     ...|..|.
Mouse  2305 QLLGPESRSHTPRAV---RKEEVDSDIQNLSHVTSACEMVADMVESLQSVLALGHKRNSTLPSFL 2366

  Fly  2817 VALSLVTSIGISLLRTHQFYAYAVTPHELIQQPGDQQQEQQADGKL-PSIPVDSLSDVDVLRQFV 2880
            .|  ::.:|.|||.|.....:|...| .|:.:.|...:.....|.: |.|||:.|.:.::|::|:
Mouse  2367 TA--VLKNIVISLARLPLVNSYTRVP-PLVWKLGWSPKPGGDFGTVFPEIPVEFLQEKEILKEFI 2428

  Fly  2881 KRLSIFGFTTRQQFEEYFMTCLLLINKLYDEHMVDQQEQ---------FQIKQVCLQAILELLMT 2936
            .|::..|:|.|.||||.:.|   |:..|..:.:|.:||:         .||..:.:|||..|:::
Mouse  2429 YRINTLGWTNRTQFEETWAT---LLGVLVTQPLVMEQEESPPEEDTERTQIHVLAVQAITSLVLS 2490

  Fly  2937 YKTFPIVG--------------------------------------------LANGQFHHTTR-W 2956
            ..|.|:.|                                            ..|...||:.: |
Mouse  2491 AMTVPVAGNPAVSCLEQQPRNKPLKALDTRFGRKLSMIRGIVEQEIQEMVSQRENTATHHSHQAW 2555

  Fly  2957 QRI-------TCDSISLKKLHKVQLLVDACNVFYQPNLERQLAYDNVIGTRTFAPNQYDLNFSWA 3014
            ..:       |...||..||            ..|.|.||:      .|..::...|..::..|
Mouse  2556 DPVPSLLPATTGALISHDKL------------LLQINPERE------PGNMSYKLGQVSIHSVW- 2601

  Fly  3015 QMEDQAAAGVGVGVGVGLS-------GGEQANTADIKQSCDADVPDMAMRNYRHFTQLSGIDFRS 3072
                         :|..::       ..|:...:|:.......|..:..|.:|     :|:|..|
Mouse  2602 -------------LGNNITPLREEEWDEEEEEESDVPAPTSPPVSPVNSRKHR-----AGVDIHS 2648

  Fly  3073 STQLVFDVLQQMI------ELNHILVLPNLVK----FCEICESRDHIKWIKERCLKLQEQVAMDD 3127
            .:|.:.::..:.|      ....::::..:|:    ..::...|...:.:.....:|:.....:|
Mouse  2649 CSQFLLELYSRWILPSSAARRTPVILISEVVRSLLVVSDLFTERTQFEMMYLTLTELRRVHPSED 2713

  Fly  3128 TISHQHIIYLLCRSQALLIPSLGELQVLCSLIGNVYLKSTHSFIRIATLQGLLCLLECCSKTNTT 3192
            .|..|:::...|::.|:|.......:.:..|:.:. |:|:|...:|..|.|:|.:|| |...:.|
Mouse  2714 EILIQYLVPATCKAAAVLGMDKTVAEPVSRLLEST-LRSSHLPSQIGALHGILYVLE-CDLLDDT 2776

  Fly  3193 MGRLSEELA--LLRSL--IVGYINRHGIIDESPLPFSVEHTKLVWTLNYSLI---------EWTS 3244
            ..:|...::  ||.:|  |...:|.|          |.:|..::....:.|:         |:::
Mouse  2777 AKQLIPVVSDYLLSNLKGIAHCVNIH----------SQQHVLVMCATAFYLMENYPLDVGPEFSA 2831

  Fly  3245 KFVPQCHLLSNTIIAANNFLKTTADEE-----LYLCVLHGLERMVVNSGVPPPGIQPTGKDAAAG 3304
            ..:..|.::            .:..||     :|.|.|.||||::::.       |.:..|.
Mouse  2832 SVIQMCGVM------------LSGSEESTPSIIYHCALRGLERLLLSE-------QLSRLDT--- 2874

  Fly  3305 EPGAEGSKAGVGVVVTPQMRHKIEKLALELLKMENEKFSIPALKLLLSCMYVGSAAQLENTELSN 3369
                                ..:.||:::.:.:::...::.||.|:|:|||.|      ..:.|.
Mouse  2875 --------------------ESLVKLSVDRVNVQSPHRAMAALGLMLTCMYTG------KEKASP 2913

  Fly  3370 GIVQD------DPEIIAQQNDKVDILLHCIKSSTRDAAWIYGQVLCQIIRDLVPPNEILTKVIKE 3428
            |...|      |.|.:....::|.:|...|:......|.:..::|.|.:.|..||.:::.|||.|
Mouse  2914 GRASDPSPATPDSESVIVAMERVSVLFDRIRKGFPCEARVVARILPQFLDDFFPPQDVMNKVIGE 2978

  Fly  3429 FLAINHPHCDVIAMIVYQVFRSAIDSSYLQMLQDWLICTLPTFLDQ-PEQQGVWGLSVIFLSASI 3492
            ||:...|:...:|.:||:||::...:....|::||::.:|..|..: |....:|.||...:|||.
Mouse  2979 FLSNQQPYPQFMATVVYKVFQTLHSAGQSSMVRDWVMLSLSNFTQRTPVAMAMWSLSCFLVSAST 3043

  Fly  3493 NLHLIKLFPLVLGIGASNSAAAATTATTATTEAEAAAPAMARKLGQHEIALFVTAAQDFHAKLSG 3557
            :..:..:.|.|:                          :...||.|.::.||...|.||:.....
Mouse  3044 SPWVSAILPHVI--------------------------SRMGKLEQVDVNLFCLVATDFYRHQIE 3082

  Fly  3558 EQ--RQRFREAF------GSFKRSQVYGRMLQCL 3583
            |:  |:.|:..|      ||     .|.|:|.||
Mouse  3083 EEFDRRAFQSVFEVVAAPGS-----PYHRLLACL 3111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
htt	NP_001263041.1	DUF3652	2726..2757	CDD:289166	6/30 (20%)
Htt	NP_034544.1	HEAT repeat	72..97	CDD:293787	6/24 (25%)
		HEAT repeat	111..133	CDD:293787	10/21 (48%)
		HEAT repeat	147..175	CDD:293787	13/27 (48%)
		HEAT 1	184..221		14/36 (39%)
		HEAT repeat	188..218	CDD:293787	12/29 (41%)
		HEAT 2	226..263		8/36 (22%)
		HEAT repeat	227..256	CDD:293787	7/28 (25%)
		Interaction with ZDHHC17. /evidence=ECO:0000250|UniProtKB:P42858	471..482		6/12 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	496..559		17/102 (17%)
		HEAT 3	783..820		12/107 (11%)
		HEAT 4	883..921		14/44 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1147..1205		6/57 (11%)
		HEAT 5	1405..1442		14/36 (39%)
		DUF3652	1506..1532	CDD:289166	7/25 (28%)
		Nuclear export signal. /evidence=ECO:0000250	2373..2382		5/8 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2611..2638		3/26 (12%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850886
Domainoid	1	1.000	257	1.000	Domainoid score	I2015
eggNOG	1	0.900	-	-		E1_28IQ9
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1657
Isobase	1	0.950	-	0	Normalized mean entropy	S8379
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0008164
OrthoInspector	1	1.000	-	-		oto92958
orthoMCL	1	0.900	-	-		OOG6_104696
Panther	1	1.100	-	-	LDO	PTHR10170
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5295
SonicParanoid	1	1.000	-	-		X6127
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.820