DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and Abca6

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_671751.2	Gene:	Abca6 / 76184	MGIID:	1923434	Length:	1624	Species:	Mus musculus

Alignment Length:	888	Identity:	184/888 - (20%)
Similarity:	315/888 - (35%)	Gaps:	280/888 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PANGPRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRR 127
            |.:.....:.|:.:|:..|.|..|....:.|..|.:.:.:..|..:||.||.||::||:.:.|..
Mouse   467 PVDPEYQGKEAIRIRNIKKEYKGKSGKVKALKGLFLDIYESQITAILGHSGAGKSSLLNILSGLY 531

  Fly   128 YMDAGEIFVLG-GKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQ 191
            ...||.:.|.. .....:......|.:|..||....:...:::|.:..|..|.|:..:::.:.:|
Mouse   532 VPTAGSVTVYNKNLSDMQDLKEIRKAIGVCPQHNVQFDALTVKENLTLFAKIKGILPQDVEQEVQ 596

  Fly   192 FLLNFLDLPS-EKRLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHIT 255
            .:|:.||:.: ...|.::||.||:|:::|.:|.:.||::|:|||||||:||..||.||..|..
Mouse   597 QILSELDMQNIRDDLAEHLSEGQKRKLTFGIATVGDPQILLLDEPTVGLDPFSRQRIWGFLKE-- 659

  Fly   256 KAGQKTVIITTHYIEEARQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLK--------LS 312
            :.....::.:|.:::||            .:||:....:.....||.. ..||||        ||
Mouse   660 RRADHVILFSTQFMDEA------------DILADRKVLIANGALKCTG-SSVFLKRKWGLGYHLS 711

  Fly   313 RIQSQKGDVTHV-NFSNNISLHAM----------------------AFGSKMDKPSSSQEGGVVG 354
            ....:..|...: :|.|:...:|.                      .|.|.:||.|..      |
Mouse   712 LFMDETCDSERLTSFINHHIPYAKLKAKTKEKLVYILPLERTSEFPEFFSDLDKYSGQ------G 770

  Fly   355 LNFHQSKEVLINDSNGSIYTLNQEPYSPPPSRRNNNPNDEESCQD---CYSNLCKITSK------ 410
            |   .|.||.::..|.....|..||.:.....:.....|.||..|   .|.:|.::...
Mouse   771 L---MSYEVSMSTLNDVFLNLEGEPSTKQDFEKRETATDSESLNDMEVAYPSLSQVQETVSTMSL 832

  Fly   411 --------GKIRALLTKNMLRMWRNVGVMLFIFALPVM-----------------QVILFCLAIG 450
                    .::|.|..|...:.:..:.::|.|..||::                 :..|:.|:.|
Mouse   833 WRMQVCAIARLRILKLKRERKAFLIILLLLGIALLPLVIEYVANALLEVKNNWEFKTDLYFLSPG 897

  Fly   451 RDPQGLN---LAIVNGEMNDTVRENCYWEDGCHFKNLGCRYLSHLNTSVVKTYYEDLDDAKEAVR 512
            :.||||.   |.|.|.|.|        .||          :|..|....:....:|.:: :.|..
Mouse   898 QLPQGLRTSLLVINNTESN--------IED----------FLQSLKHQNIVLEVDDFEN-RNATN 943

  Fly   513 KGTAWGAVYISENFTDAFIARANLGRDSDDETIDSSEVK------VWLDMSNQQIGVMLNRDIQL 571
            ..:..||:.:|             ||..|.........|      :.:::.:..|..|||....
Mouse   944 SLSYNGAIIVS-------------GRQKDYRFSAVCNTKRLHCFPILMNVISNGILHMLNHTQY- 994

  Fly   572 AFRDFAMGLLGQCGSNPKLGDVPIQFRDPIYGTMNPSFTDFVAPGVILTIVFFLAV--------A 628
                                   |:.::.|:.    .|...|..|:..|.:|.|.|        |
Mouse   995 -----------------------IRIKEDIFS----PFIVLVWTGIQETCLFILCVICSLSPHIA 1032

  Fly   629 LTSSALIIERTEGLLDRSWVAGVSP-------------------------------------FEI 656
            ::|.:...::.:..|   |::|:.|                                     .||
Mouse  1033 MSSVSDYKKKADSQL---WISGLYPSAYWCGQAVVDISLFSGMLLTSYFTSYTSKLLNIDMTSEI 1094

  Fly   657 LFSHVITQFVVMCGQTTLVLIFML-VVFGVTNNGDLFWVIVLTLLQGMCGMCFGFLISSVCELER 720
            :||.::  ..:.|..:.:.|.::: .|||........|.|           ||..:|:...|
Mouse  1095 VFSVIV--LALGCAASLVFLTYVISFVFGKRKKNSTLWSI-----------CFLLVIAITFE--- 1143

  Fly   721 NAIQLALGSFYPTLLLSGVI----WPIEGMPVVLR------YIS--------------LCLPLTL 761
               ::|.|.|...|::|..:    :.:.|:.|||.      ||.              |||
Mouse  1144 ---KVANGPFNEALVISATMLVPSFALNGLLVVLEMRAYQYYIEFEEIKHGLSAVDLLLCL---- 1201

  Fly   762 ATSSLRSILTRGWAILESDVYIGYVSTLSWIVGFLVLTLLVLR 804
                                 |.|:.||.:|   .||..|.|:
Mouse  1202 ---------------------IPYIHTLLFI---FVLRCLELK 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	62/218 (28%)
		ABC_DR_subfamily_A	74..286	CDD:213197	59/213 (28%)
		pip_yhgE_Nterm	427..>474	CDD:276270	16/66 (24%)
		ABC2_membrane_3	429..801	CDD:289468	84/467 (18%)
		ABC2_membrane	601..769	CDD:279410	43/237 (18%)
Abca6	NP_671751.2	rim_protein	<169..1600	CDD:130324	184/888 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900