DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and Abca12

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_780419.2	Gene:	Abca12 / 74591	MGIID:	2676312	Length:	2595	Species:	Mus musculus

Alignment Length:	586	Identity:	144/586 - (24%)
Similarity:	243/586 - (41%)	Gaps:	120/586 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SAIISTDSAMAATNNDGG-TQPNAVAAWGAPAN---GPRNTQAAVSVRHAFKAYGKKKNANQVLN 94
            :.::.|:..|..||.... |.|:.    ..|:|   .|::.|..|::....|.||.|    ..:.
Mouse  1306 NGLMFTNIMMQNTNPSASKTSPDC----AFPSNIEPEPKDLQVGVALHGVTKIYGSK----TAVE 1362

  Fly    95 NLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQE 159
            |||:...:|.|..|||.:|.||||.:|.:.|.....||.|||.|....|..:.| .|.:|...|.
Mouse  1363 NLNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGATAGTIFVYGKDIKTDLNTV-RKNMGVCMQH 1426

  Fly   160 IALYGEFSIQETMMYFG------WIFGMDTK-EILERLQFLLNFLDLPSEK-RLVKNLSGGQQRR 216
            ..|:...:.:|.::.:|      |     || ::.|.::..|....|.|.: :.|..||||.:|:
Mouse  1427 DVLFSYLTTKEHLLLYGSIKVPHW-----TKTQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRK 1486

  Fly   217 VSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEAR-QAHTIGL 280
            :|.::||:....::|||||:.||||..|:|||: ::...|.. :|:|::||:::||. .:..|..
Mouse  1487 LSISIALIGGSRVVILDEPSTGVDPCSRRSIWD-VISKNKTA-RTIILSTHHLDEAEVLSDRIAF 1549

  Fly   281 MRSGHLLAEESPSVL---------LSIYKCIS---------------------LEEVFLKLSRIQ 315
            :..|.|....||..|         |::.|..|                     |.|.:||    :
Mouse  1550 LEQGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLDTNAICDTVAVTAMIQSHLPEAYLK----E 1610

  Fly   316 SQKGDVTHV--NFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLIN-------DSNGS 371
            ...|::.:|  .||..:|...::....:||.......|..|::....:||.:|       .||.|
Mouse  1611 DIGGELVYVLPPFSTKVSGAYLSLLRALDKGMGKLNIGCYGISDTTVEEVFLNLTKDSQKSSNMS 1675

  Fly   372 IYTLNQEPYSPPPSRRNNNPND-EESCQDCYSNLCKITSKG-----------KIRALLTK---NM 421
            :..|.|.....|.:...:.|:| ..|..:......|:.::.           ||.|:|.|   :.
Mouse  1676 LEHLTQRKVGNPSANGTSTPDDLSVSSSNFTDRDDKVLTRSEKLEGFGLLLKKIMAILIKRFHHT 1740

  Fly   422 LRMWRNVGVMLFIFALPVMQVILFCLAIGRDPQGLNLAIVNGEMNDTVRENCYWEDGCHFKNLGC 486
            .|.|:.      :.|..::.::....|:|.           |.:.|:  .|.|.|........|
Mouse  1741 RRNWKG------LIAQVILPIVFVATAMGL-----------GTLRDS--SNSYPEIMISPSIYG- 1785

  Fly   487 RYLSHLNTSVVKTYYEDLDDAKEAVRKGTAW---GAVYISENFTD-AFIARANLGR-DSDDETID 546
                   ||....:|.:.|.:...: ....|   |...:..|.:| ..:.:.:||: ::..|.||
Mouse  1786 -------TSEQTAFYANFDPSTSGL-VSALWNFPGIDNVCLNTSDLQCLKKDDLGKWNTSGEAID 1842

  Fly   547 S 547
            :
Mouse  1843 N 1843

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	73/225 (32%)
		ABC_DR_subfamily_A	74..286	CDD:213197	72/220 (33%)
		pip_yhgE_Nterm	427..>474	CDD:276270	6/46 (13%)
		ABC2_membrane_3	429..801	CDD:289468	22/124 (18%)
		ABC2_membrane	601..769	CDD:279410
Abca12	NP_780419.2	ABC2_membrane_3	<1006..1267	CDD:289468
		NosY	<1108..1269	CDD:224196
		ZnuC	1346..1570	CDD:224046	76/235 (32%)
		ABC_subfamily_A	1350..1565	CDD:213230	74/226 (33%)
		ABC2_membrane_3	<1913..2174	CDD:289468
		CcmA	2253..2567	CDD:224054
		ABC_subfamily_A	2254..2477	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810