DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snu and abca12

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	XP_686632.6	Gene:	abca12 / 558335	ZFINID:	ZDB-GENE-030131-9790	Length:	5913	Species:	Danio rerio

Alignment Length:	926	Identity:	188/926 - (20%)
Similarity:	334/926 - (36%)	Gaps:	256/926 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLG 138
            ||:....|.|| |:||   ::|||::..:|.:..|||.:|.||||.:|.:.|......|.|.|.|
Zfish  4666 VSLYGLTKTYG-KRNA---VDNLNLSFYEGHVTSLLGHNGAGKTTTMSLLTGLFAPTVGTIEVYG 4726

  Fly   139 GKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFG--MDTKEILERLQFLLNFLDLPS 201
            .........| .|.:|...|...|:...:.:|.::.:..|..  ...:|:.|::..:|...|:.:
Zfish  4727 MDMQMFIDDV-RKEMGVCMQYDVLFDHLTTKEHLLLYAQIKAPHWTKQEVKEQVHKILMETDMHA 4790

  Fly   202 EK-RLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIIT 265
            .: :.|..||||.:|::|.::|.:....|::|||||.||||..|:|||:  :.|....::|:|::
Zfish  4791 HRHKRVGTLSGGMKRKLSISIAFIGGSRLVVLDEPTTGVDPCSRRSIWD--IIIQHKQERTIILS 4853

  Fly   266 THYIEEAR-QAHTIGLMRSGHLLAEESPSVL---------LSIYKCISLEEVFLKLS-------- 312
            ||:::||. .:..|..:..|.|....||..|         |::.|.:...:...|..
Zfish  4854 THHLDEAEVLSDRIAFLERGGLKCCGSPFYLKDKLAKGYNLTLTKKVETADSKEKFDYEKLRDFI 4918

  Fly   313 --------RIQSQKGDVTHV----NFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLI 365
                    :...:.||:.:.    ...|....|::.  :.:|:.......|..|::....:||.:
Zfish  4919 HSHLPDARQKDREMGDLVYALPPYTPQNASEYHSLL--NSLDQNLDKLHLGCYGISDTTLEEVFL 4981

  Fly   366 NDSNGSIYTLNQEPYSPPPSRRNNN-----PNDEESCQDCY-SNLCKITSKGKIR---------- 414
            ..:...:.....|.:|...|...|:     .:..|.|...| .....:|....:|
Zfish  4982 QLTRDDLEPKESETWSVSESVIENDMFASRDSLSEDCNSMYLGEKASLTGNSTVRGFALGVQRVI 5046

  Fly   415 ALLTKNM---LRMWRNVGVMLFIFALPVMQVILFCLAIGRDPQGLNLAIVNGEMN---DTVRENC 473
            |:|.|.:   .|.|:.      :|:..::.|:....|:|       |..:..::.   :.|....
Zfish  5047 AMLLKRVHHSRRDWKG------LFSQVLLPVLFVIAAMG-------LGSIKSDLQHFPEIVLSPA 5098

  Fly   474 YW---EDGCHFKNLGCRYLSHLNTS-VVKTY--YEDLD-----DAKEAVRKG------TAWGA-- 519
            .:   |....|.|      .:.||| :|.|.  |..:|     |..:.|.||      ..|.:
Zfish  5099 LYHVDEQYAFFSN------QNPNTSRLVDTMMSYPGIDHVCMTDPTDPVCKGRPSTGSQTWVSGG 5157

  Fly   520 -----------------------------------VY--ISENFTDAFIARAN------------ 535
                                               ||  ...|..:..:|.||
Zfish  5158 NSSATFTTCKCSNQVQSCPAQGYDPPRKRCPSSQIVYNLTGVNIENYLLATANNFIRDRYGGWEF 5222

  Fly   536 -------LGRDSDDETIDSSEVKVWLDM-SNQQIGVMLNRDIQLAFR---------DFAMGLLGQ 583
                   |..|..|...:.:..|||.:. .:..:...||.......|         .:|:.:
Zfish  5223 GKPLPIDLKMDMLDVPANRTLSKVWYNSEGHHSMPAYLNSLNNFFLRSSLPPEKRYQYAISI--- 5284

  Fly   584 CGSNPKLGDVPIQFRDPIYGTMNPSFTDFVAPGVILTIVFFLAVA----LTSSALIIERTE---G 641
             .|:|..|.|..:              |.:..|::..:|....:.    :|:|.:|.|..|   |
Zfish  5285 -SSHPYPGQVQDE--------------DLMVGGLVSILVALCVLTGYSIMTASFVIYEVQEHHTG 5334

  Fly   642 LLDRSWVAGVS-PF---------EILFSHVITQFVVMCG----------QTTLVLIFMLVVFGVT 686
            ......::|:| ||         ..|:...:...|||..          |....:..:||:||.:
Zfish  5335 SKRLQQISGISEPFYWIINFFYDMALYMIPVVLSVVMVAAFQLPAFTERQNLAAVTLLLVLFGFS 5399

  Fly   687 NNGDLFWVIVLTLLQGMCGMCFGFLISSVCELERNAIQLALGSFYPTLLLSGVIW---------- 741
            .   ..|:.:|:.:.....|.|   |..||      |.|.:.  ..|::.:.:|:
Zfish  5400 T---FPWMYLLSAMFKDTEMAF---IGYVC------INLFIS--VNTIISTSIIYFLGQLNQNDQ 5450

  Fly   742 PIEGMPVVLRYISLCLP--------LTLATSSLRSILTRGWAILESDVY--------IGYVSTLS 790
            .|:.:...:..|.|..|        :.||...::..:..|:.:   |.|        :|::....
Zfish  5451 SIQNIYQTMSNIFLVFPQFSFGNGLMELARVDMQVQILSGFGV---DAYKNPFSMDVLGWMFISM 5512

  Fly   791 WIVGFLVLTLLVLRAK 806
            ::.||:..||.:|..|
Zfish  5513 FLQGFICFTLRLLLNK 5528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	69/219 (32%)
		ABC_DR_subfamily_A	74..286	CDD:213197	68/215 (32%)
		pip_yhgE_Nterm	427..>474	CDD:276270	6/49 (12%)
		ABC2_membrane_3	429..801	CDD:289468	87/512 (17%)
		ABC2_membrane	601..769	CDD:279410	39/212 (18%)
abca12	XP_686632.6	ABC2_membrane_3	4268..4588	CDD:289468
		CcmA	4666..4941	CDD:224054	77/281 (27%)
		ABC_subfamily_A	4666..4885	CDD:213230	71/225 (32%)
		ABC2_membrane_3	<5245..5493	CDD:289468	51/279 (18%)
		CcmA	5572..5886	CDD:224054
		ABC_subfamily_A	5573..5799	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910