DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and abca4

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001011033.1	Gene:	abca4 / 496442	XenbaseID:	XB-GENE-1000810	Length:	2359	Species:	Xenopus tropicalis

Alignment Length:	950	Identity:	176/950 - (18%)
Similarity:	306/950 - (32%)	Gaps:	367/950 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDA 131
            |......|.::...|.|  :......::.:|:|..:|.|...||.:|.||||.||.|.|.....:
Frog   990 PPGMVPGVYIQDLVKVY--ENTYKPAVDRMNITFYEGQITAFLGHNGAGKTTTLSIITGLFPPTS 1052

  Fly   132 GEIFVLGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNF 196
            |.::|.|....|....: .:.:|..||...|:...:::|.::::..:.|...|:...:.:.:|..
Frog  1053 GTVWVRGRDIQTHMDSI-RQSLGMCPQHNILFRHLTVEEHILFYAQLKGKSRKQAERQAEVMLED 1116

  Fly   197 LDLPSEKR-LVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQK 260
            :.:|.::. ..:|||||.||::|.|:|.:.:.::::|||||.||||..|:|||:.|:.. ::| :
Frog  1117 MGIPHKRNDEAQNLSGGMQRKLSVALAFVGESKVVVLDEPTSGVDPYSRRSIWDLLLKY-RSG-R 1179

  Fly   261 TVIITTHYIEEA-RQAHTIGLMRSGHLLAEESPSVLLSIY------------------------- 299
            |:|::||:::|| .....|.::..|.|....||..|.:.:
Frog  1180 TIILSTHHMDEADLLGDRIAIVSQGKLFCSGSPLFLKNCFGTGFYLTLVRRMRNIKDTGKKDSAS 1244

  Fly   300 -------KCIS------------------------------------------------------ 303
                   .|.|
Frog  1245 CQSDCSCPCSSCTPKVKENLLEQELDGDVSGLTELIHHHVPEAKLLESIGQELIYLLPSKDFKFR 1309

  Fly   304 ---------------------------LEEVFLKLS-------------RIQSQK--------GD 320
                                       |||:|||::             .:|.:|        ..
Frog  1310 AYASLFRELEETLGDLGLSSFGISDTPLEEIFLKVTADSVTGTETPEEWMLQQRKSRTSLGVDNQ 1374

  Fly   321 VTHVNFSN---NISLHAMAFGSKMDK-PSSSQEGGVVGLNFHQSK--EVLINDSNGSI------- 372
            .|.:|..|   ..|:...:...|.:| |.:..:....|....|.|  |:|....|..|
Frog  1375 TTVINIDNKGQESSIRKDSHHCKAEKNPPNINDREADGRGSRQIKGTELLQQQFNALIIKRFKHA 1439

  Fly   373 -----------------------YTLNQEPYSPPPSR--------------RNNNPNDEE----- 395
                                   :||...|:...||.              .|..|.:|:
Frog  1440 TRSHKDFFAQIVLPASFVLLALVFTLIVPPFGEYPSLTLHPWIYGQQFVFFSNEQPGNEQMATFS 1504

  Fly   396 -----------------------SC--------------------------QDCYSNLCKITSKG 411
                                   .|                          :|..|..|..:|:.
Frog  1505 NAFLNSPGLGTRCMKDQPLSKKYQCTNTSNEWTMPAVSPSVTNMLLSQEWTRDNPSPSCTCSSRS 1569

  Fly   412 KIRAL-------------------------LTKNML------------------RMWRN------ 427
            |:..|                         ||:..:                  :.|.|
Frog  1570 KLMMLPECPEGAGGRPPPQRIQPSSEIIQDLTERNISDFLLKTYPDLIRSSMKSKYWVNEQRYGG 1634

  Fly   428 --VGVMLFIFALPVMQVILFCLAIGRDPQ---GLNLAIVNGEMNDTVRENCYWEDGCHFKNLGCR 487
              ||..|.:..:....::.|...:|:...   |.....::.|: .|..:|...||.
Frog  1635 ISVGGKLPVLHVKGGDIVSFFSQVGQMTNVTAGTTTKAISQEL-QTFLQNLETEDN--------- 1689

  Fly   488 YLSHLNTSVVKTYYEDLDDAKEAVRKGTAWGAVYISENFTDAFIARANLGRDSDDETIDSSEVKV 552
                     :|.::.:         ||  |.::.|..|..:..|.|||||.|.|.|....:.:..
Frog  1690 ---------IKVWFNN---------KG--WHSMVIFINVANNAILRANLGADKDPEEFGITTMNH 1734

  Fly   553 WLDMSNQQIG----VMLNRDIQLAF----------RDFAMGLLGQCGSNPKLGDVPIQF----RD 599
            .|:::..|:.    :..:.|:.:|.          ..|.:.|:.:..||.|    .:||    ..
Frog  1735 PLNLTKDQLSEVTVLTTSVDVVVAICVIFAMSFIPASFVLYLIQERVSNAK----HLQFVSGVTP 1795

  Fly   600 PIYGTMNPSFTDFV--APGVILTIVFFLAV---ALTSSALIIERTEGLLDRSW--VAGVSPFEIL 657
            .||...|.:: |.:  |..|.:.::.|:|.   |.|||:.:......|....|  :..:.|...|
Frog  1796 AIYWLTNFAW-DIINYAISVAMVVIIFIAFDKKAYTSSSNLPALIALLFFYGWAVIPMMYPASYL 1859

  Fly   658 FSHVITQFVVM-C-----GQTTLVLIFMLVVFGVTNNGDL 691
            |:...|.:|.: |     |..:..:.|:|.:|  .||..|
Frog  1860 FNVPSTAYVALSCINLFIGINSSAITFILDLF--ENNRSL 1897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	65/218 (30%)
		ABC_DR_subfamily_A	74..286	CDD:213197	64/213 (30%)
		pip_yhgE_Nterm	427..>474	CDD:276270	10/57 (18%)
		ABC2_membrane_3	429..801	CDD:289468	62/296 (21%)
		ABC2_membrane	601..769	CDD:279410	26/103 (25%)
abca4	NP_001011033.1	rim_protein	1..2347	CDD:130324	175/949 (18%)
		ABC2_membrane	604..>778	CDD:304374
		ABC_subfamily_A	997..1216	CDD:213230	67/223 (30%)
		ABC_subfamily_A	2013..2233	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910