DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and Abca17

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001026792.2	Gene:	Abca17 / 381072	MGIID:	3625331	Length:	1733	Species:	Mus musculus

Alignment Length:	821	Identity:	179/821 - (21%)
Similarity:	317/821 - (38%)	Gaps:	215/821 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PANG------PRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLS 121
            |:.|      |.|....:.::|.:|.:...::....:.:|:|.:.||.:..|||.:|.||||:.|
Mouse   502 PSKGNFMQDEPTNQMNTIEIQHLYKVFYSGRSKRTAIRDLSMNLYKGQVTVLLGHNGAGKTTVCS 566

  Fly   122 CIVGRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEI 186
            .:.|......|..::.|.:. ::......|.:|:.||...|:..|::.:.:.::|.:.|:..::.
Mouse   567 VLTGLITPSKGHAYIHGCEI-SKDMVQIRKSLGWCPQHDILFDNFTVTDHLYFYGQLKGLSPQDC 630

  Fly   187 LERLQFLLNFLDLPSE-KRLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNH 250
            .|:.|.:|:.|.|..: ....|.||||.:|::|..:||:...::|||||||.|:|...|::||:.
Mouse   631 HEQTQEMLHLLGLKDKWNSRSKFLSGGMKRKLSIGIALIAGSKVLILDEPTSGLDSPSRRAIWDL 695

  Fly   251 LVHITKAGQKTVIITTHYIEEA-RQAHTIGLMRSGHLLAEESPSVL---------LSIYK---C- 301
            |..  :.|.:||::|||:::|| .....|.::..|.|....|||.|         ::|.|   |
Mouse   696 LQQ--QKGDRTVLLTTHFMDEADLLGDRIAILAKGELQCCGSPSFLKQKYGAGYYMTIIKTPLCD 758

  Fly   302 -ISLEEVF---LKLSRIQSQKGDVTHVNFS-----------NNISLHAMAFGSKMDKPSSSQEGG 351
             ..|.||.   :..:.::|..|:...|...           |::.|.....|......|.:
Mouse   759 TSKLSEVIYHHIPNAVLESNIGEEMIVTLPKKTIHRFEALFNDLELRQTELGISTFATSVT---- 819

  Fly   352 VVGLNFHQSKEVLIN-----DSNGSIYTLNQEPYSPPPSRRNNNPNDEESCQDCYSNLCKITSKG 411
                   ..:||.|.     |.:.::.|..:....|.| |.:..|.|...|  .:|....::::.
Mouse   820 -------TMEEVFIRVCKLADPSTNVLTEKRHSLHPLP-RHHRVPVDRIKC--LHSGTFPVSTEQ 874

  Fly   412 KIR-------------ALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAIGRDPQGLNLAIVNG 463
            .:|             |:|.|.:....||..::|.:..|..:.:|:..|.
Mouse   875 PMRLNTGFCLLCQQFYAMLLKKITYSRRNWMLVLSVQVLLPLAIIMLSLT--------------- 924

  Fly   464 EMNDTVRENCYWEDGCHFKNLGCRYLSHLNTSV-VKTYYEDLDDAKEAVRKGTAWGAVYISENFT 527
                             |.|...|.|.::...: ::||             |......:|:||
Mouse   925 -----------------FFNFKLRKLDNVPLELTLQTY-------------GQTIVPFFIAEN-- 957

  Fly   528 DAFIARANLGRDSDDETIDSSEVKVWLDMSNQQIGVMLNRDIQLAFRDFAMGLLGQCGSNP---- 588
                  ::|     |..:....||:.:......:      .||.:..||   ||.:....|
Mouse   958 ------SHL-----DPQLSDDFVKMLVAAGQVPL------RIQGSVEDF---LLKKAKEAPEGFD 1002

  Fly   589 KLGDVPIQFRD-PIYGTMNPSFTD--FVAPGVILTIVFFLAVALTSSA-------------LIIE 637
            ||..|...|.| ..:.|:...|.:  :.:|.:.||:|..|...|.|.|             ..||
Mouse  1003 KLYVVAASFEDVNNHTTVKALFNNQAYHSPSLALTLVDNLLFKLLSGANASITTTNYPQPQTAIE 1067

  Fly   638 RTEGLLDR---------SWVAGVSPFEILFSHVITQFVVMCGQTTLVLIFMLVVFGVTNNGDLFW 693
            .:|.:|.:         :::.|::.....||      ::..|:.::....:..|.||:.  .:||
Mouse  1068 VSESILYQGPKGHYLVVNFLFGIAFLSSSFS------ILTVGEKSVKSKSLQFVSGVST--AVFW 1124

  Fly   694 VIVLTLLQGMCGMCFGFLISSVCELERNAIQLALGSFYPTLLLSGV-IW-------PIEGMPVVL 750
                  |..:......||:                   |||||..| :|       ..|.:|.|:
Mouse  1125 ------LSALLWDLISFLV-------------------PTLLLVLVFLWYKEEAFAHHESIPAVV 1164

  Fly   751 RYISL----CLPLTLATSSLRSILTRGWAILESDVYIGYVS 787
            ..:.|    .:||....|.  |..|.|.|.::..|.:.::|
Mouse  1165 LIMMLYGWAVIPLVYTVSF--SFNTPGSACVKLVVMLTFLS 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	64/218 (29%)
		ABC_DR_subfamily_A	74..286	CDD:213197	63/213 (30%)
		pip_yhgE_Nterm	427..>474	CDD:276270	5/46 (11%)
		ABC2_membrane_3	429..801	CDD:289468	76/401 (19%)
		ABC2_membrane	601..769	CDD:279410	40/203 (20%)
Abca17	NP_001026792.2	rim_protein	<209..1684	CDD:130324	179/821 (22%)
Abca17	NP_001026792.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1681..1733
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810