DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and ABCA

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_608445.2	Gene:	ABCA / 33103	FlyBaseID:	FBgn0031170	Length:	1714	Species:	Drosophila melanogaster

Alignment Length:	858	Identity:	175/858 - (20%)
Similarity:	317/858 - (36%)	Gaps:	188/858 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDA 131
            |......:.:||..|.:|.|    .|:..|:|.:.:..|..|||.:|.||||.:|.:.|.....:
  Fly   531 PEGKHIGLQMRHLKKRFGNK----MVVKGLSMNMFEDEITVLLGHNGAGKTTTISMLTGMFPPTS 591

  Fly   132 GEIFVLGGKPGTRGSGVPGKR--VGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLL 194
            |...:.|....|   .:.|.|  :|..||...|:.|.|:...:.:|..:.|:..|.:.:.:...|
  Fly   592 GTAIINGSDIRT---NIEGARMSLGICPQHNVLFDEMSVSNHIRFFSRMKGLRGKAVEQEVAKYL 653

  Fly   195 NFLDLPSEKRLVKN-LSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAG 258
            ..::|..:..:..: ||||.:|::|...||..|.::::.|||:.|:||..|:.:|: |:...|.|
  Fly   654 KMIELEDKANVASSKLSGGMKRKLSVCCALCGDTKVVLCDEPSSGMDPSARRQLWD-LLQQEKVG 717

  Fly   259 QKTVIITTHYIEEAR-QAHTIGLMRSGHLLAEESPSVLLSIYK------CISLE-----EVFLKL 311
             :|:::|||:::||. ....|.:|..|.|..:.:...|...|.      |:..:     ||...|
  Fly   718 -RTLLLTTHFMDEADVLGDRIAIMCDGELKCQGTSFFLKKQYGSGYRLICVKRDDCETNEVTALL 781

  Fly   312 SR--------------IQSQKGDVTHVNFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKE 362
            ::              :..|..|.....|..       .|| ::::.|........|:.....:|
  Fly   782 NKYIPGLKPECDIGAELSYQLPDSASAKFEE-------MFG-QLEEQSDELHLNGYGVGITSMEE 838

  Fly   363 VLI-----NDSNGSIYTLNQEPYSPPPSRRNNNPNDEESCQDCYSNLCKITS-----KGKIRALL 417
            |.:     .|:.|:|.. ..|..:.....|..:.|:.......:|...::..     ..:.:|:|
  Fly   839 VFMKVGAEKDNTGNIKD-QHEIMNGGSGFRGEDDNESVQSDGIFSENRRLLQGLQLLSNQWKAML 902

  Fly   418 TKNMLRMWRNVGVMLFIFALPVMQVILFCLAIGRDPQG-------LNLAIVNGEMNDTVRENCYW 475
            .|..|..|||..::|....:||..|::..|.|  ..||       :.:::....:..||.:....
  Fly   903 LKKFLYTWRNKLLLLIQNIMPVFFVVVTILII--KTQGTFQELKPITISLTQYPLAVTVLDRSNV 965

  Fly   476 EDGCHFKNLGCRYLSHLNTSVVKTYYEDLDDAKEAVRKGTAWGAVYI-SENFTDAFIARANLGRD 539
            ::|..::              :...||||     |...|:.:|.... ::.|.|..:   :||:.
  Fly   966 QNGTGYE--------------IANKYEDL-----ARSYGSNYGLELTGTQGFEDYIL---DLGKT 1008

  Fly   540 SD---------DETIDSSEVKVWLDMSNQQIGVMLNRDIQLAFRDFAMG---------------- 579
            ..         ..||..|::..||:........:....:..|..|...|
  Fly  1009 IQVRINSRYLVAATITESKITAWLNNQALHTAPLTVNMVHNAIADKLFGSSVKIQVTNAPLPYTT 1073

  Fly   580 --LLGQCGSNPKLGDVPIQFRDPIYGTMNPSFTDFVAPGVILTIVFFLAVALTSSALIIERTEGL 642
              ||.|..:...|            ||...|...|....|....:.||.....|.|.:::...|:
  Fly  1074 STLLSQLSTGNNL------------GTQLASNLCFCMCFVSSIYILFLIKERESRAKLLQFVGGV 1126

  Fly   643 LDRSWVAGVSPFEILFSHVITQFVVMCGQTTLVLIFMLVVF---GVTNNGDLFWVIVLTLLQGMC 704
              :.|...:|.|...|:..|.        |.|:::..:|.|   |::..|:|....:|.||.|..
  Fly  1127 --KVWTFWLSQFICDFASYIV--------TALIVVITIVCFQETGLSTFGELGRYYLLLLLFGFA 1181

  Fly   705 GMCFGFLIS--------SVCELERNAIQLALGSFYPTLLLSGVIWPIEGMPVVLRYISLCLPLTL 761
            .:.|.:::|        ....:....|...:..|...:::|..::..:....:|.:|....|...
  Fly  1182 VLPFIYIMSLFFREPATGFARVSIVNIFCGMALFIVVVVMSSELFDTKDTADILGWIFRIFPHFS 1246

  Fly   762 ATSSLRSILTR--------------------------------GW---AILESDVYIGYVSTLSW 791
            ...||..:.|.                                .|   .:|...||:    .::.
  Fly  1247 LAMSLNKVYTNTATRNACAKAGALPPILLCELVPQCCNLKPYFAWEEPGVLPETVYM----AVTG 1307

  Fly   792 IVGFLVLTLLVLR 804
            :|.||::.:|..|
  Fly  1308 VVFFLIIIVLEFR 1320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	65/220 (30%)
		ABC_DR_subfamily_A	74..286	CDD:213197	64/215 (30%)
		pip_yhgE_Nterm	427..>474	CDD:276270	11/53 (21%)
		ABC2_membrane_3	429..801	CDD:289468	78/452 (17%)
		ABC2_membrane	601..769	CDD:279410	36/178 (20%)
ABCA	NP_608445.2	ABC2_membrane_4	254..434	CDD:289500
		ABC2_membrane_3	<269..475	CDD:289468
		CcmA	538..843	CDD:224054	80/321 (25%)
		ABC_subfamily_A	538..755	CDD:213230	65/225 (29%)
		ABC2_membrane_3	913..1316	CDD:289468	78/452 (17%)
		ABC_subfamily_A	1369..1587	CDD:213230
		drrA	1376..1702	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46598
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810