DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and CG34120

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001285513.1	Gene:	CG34120 / 318066	FlyBaseID:	FBgn0083956	Length:	1998	Species:	Drosophila melanogaster

Alignment Length:	823	Identity:	175/823 - (21%)
Similarity:	301/823 - (36%)	Gaps:	246/823 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLGG 139
            |:.:..|.||.|    ..::||::...:..:..|||.:|.||:||:..:.|:....:|::.:.|
  Fly   859 SLVNVSKLYGSK----CAVSNLSLDFARNQVSCLLGRNGAGKSTLIKLLTGQIRQSSGKVLLAG- 918

  Fly   140 KPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYF-------GWIFGMD--TKEILERLQFLLN 195
                      ..:||...|:..|....:.:|.:..:       |...|::  ..|:.:.|| .||
  Fly   919 ----------EHQVGVCWQDNILIPTLTAREHLQLYAQIKIPPGGSGGVEEIRSEVAQTLQ-SLN 972

  Fly   196 F---LDLPSEKRLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKA 257
            |   ...||.:     ||||.:||:..|:|.:..|.::|||||..|||...|:.|| .|:...:.
  Fly   973 FGKHESYPSWQ-----LSGGYRRRLCVAIAFIASPSVVILDEPCNGVDAKARKDIW-QLIERLRQ 1031

  Fly   258 GQKTVIITTHYIEEARQ-AHTIGLMRSGHLLAEESPSVLLSI--------YKCISLEEVFLKLSR 313
            | :.||..||:::||:. :.::.:||:|.::|:.|...|..:        .:|.....|...:.:
  Fly  1032 G-RAVIFATHFMDEAKYLSDSLVIMRNGRIIAQHSRDSLQRLCTSNYSIRLRCADATGVTFVIQK 1095

  Fly   314 IQS--QKGDVTH---VNFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLINDSNGSIY 373
            .|.  .:..|||   .::.::::::| ::...:      ..|.|..|...||:....:.|:..:.
  Fly  1096 AQQLLPQTQVTHSGAADYPHSLTINA-SYAEHL------TPGAVEFLELLQSQVTAGSISDVELT 1153

  Fly   374 T------------LNQEPYSP--PPSRRNNNPNDEESCQDCYSNLCKITSKGKIRALLTKNMLRM 424
            |            .|.|...|  |.|.|:..........|.....||     :.|.|:.|.:..:
  Fly  1154 TSSSLEQEFEQLNRNGEDAGPRRPASDRSGVVAGPAMITDEPPTACK-----QFRLLMGKRLRHL 1213

  Fly   425 WRNVGVMLFIFALPVMQVILFC----------------LAIGRDPQGLNLAIVNGEMNDTVRENC 473
            .||..::|::..||.:  ...|                |.:.|.........::.|...:..|..
  Fly  1214 SRNYRLLLYVLLLPAL--FELCAMWFVSYRLEDDFDTVLPLSRSLYPQTAQFLSHERATSFSEKL 1276

  Fly   474 YWEDGCHFKNLG-CRYLSHLNTSVVKTYYEDLDDAKEAVRKGTAWGAVYISE--------NFTDA 529
            |.:......:|| ||.   .||| .::|...|:          :||.  .||        |.:.|
  Fly  1277 YPQLRTSCDHLGECRV---FNTS-QQSYDWVLN----------SWGE--YSERRYGGYGLNGSGA 1325

  Fly   530 FIARANLGRDSDDETIDSSEVKVWLD----------MSNQQIGVM-LNRDIQLAFRDFA-MGLLG 582
            .:...|.|..|         :..||:          |::.:..:: ||...:|.|.:.: ..:|.
  Fly  1326 TVWYNNKGYHS---------MMAWLNDLNSELLRTTMNDSESSILTLNEPWKLGFAELSTSSILR 1381

  Fly   583 QCGSNPKLGDVPIQFRDPIYGTMNPSFTDFVAPGVILTIVFFLAVALTSSALIIERTEG------ 641
            |.|.                |:|          ..||.|.|.|.||..|..|:.||..|
  Fly  1382 QAGD----------------GSM----------VFILLIAFGLVVASGSVYLVNERVNGEKLQQR 1420

  Fly   642 ---------------------------------------LLDRSWVAGVSPFEILFS-------H 660
                                                   .:||..:.|:....:.||       |
  Fly  1421 LCGVSAVTYWLVALVWDYLVMVLGLIVCLVVILMFGMPVFVDRQQLVGIIGLSLAFSFACVPSVH 1485

  Fly   661 V---------ITQFVVMCGQTTLVLIFM--LVVFGVTNNGDLF--WVIVL----------TLLQG 702
            |         |....:.|....:.|:.|  :::.||..:|..:  |...|          .|..|
  Fly  1486 VAEKIFSDSSIAIVSIFCANLIVPLVTMGIILILGVVGDGPAWDDWRHALNQAFLIFPIHALGDG 1550

  Fly   703 MCGMCFGFLISSV---CELERNAIQLA---LGSFYPTLLLSGV 739
            ...:|..::::.|   .:::.....||   ||..:..|||.||
  Fly  1551 FLELCKNYMVALVFRRYDIDSYKHPLASDLLGRHFTALLLVGV 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	65/227 (29%)
		ABC_DR_subfamily_A	74..286	CDD:213197	64/223 (29%)
		pip_yhgE_Nterm	427..>474	CDD:276270	9/62 (15%)
		ABC2_membrane_3	429..801	CDD:289468	80/429 (19%)
		ABC2_membrane	601..769	CDD:279410	43/220 (20%)
CG34120	NP_001285513.1	ABC2_membrane_3	<621..760	CDD:289468
		ABC_subfamily_A	859..1073	CDD:213230	67/236 (28%)
		drrA	865..1162	CDD:130256	80/326 (25%)
		ABC2_membrane_3	1230..1601	CDD:289468	77/415 (19%)
		Mem_trans	1436..>1552	CDD:304621	18/115 (16%)
		ABC_subfamily_A	1651..1857	CDD:213230
		drrA	1666..1945	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46598
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.810