DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snu and Abca4

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001101191.1	Gene:	Abca4 / 310836	RGDID:	1309445	Length:	2290	Species:	Rattus norvegicus

Alignment Length:	247	Identity:	71/247 - (28%)
Similarity:	132/247 - (53%)	Gaps:	7/247 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLG 138
            |.|::..|.:  :..:...::.||:|..:..|...||.:|.||||.||.:.|.....:|.: ::|
  Rat   907 VCVKNLVKVF--EPGSRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTV-LIG 968

  Fly   139 GKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNFLDLPSEK 203
            ||..........:.:|..||...|:...::.|.::::..:.|...:|....::.:|....|..::
  Rat   969 GKDIEISLDAVRQSLGMCPQHNILFHHLTVAEHILFYAQLKGRSWEEARLEMEAMLEDTGLHHKR 1033

  Fly   204 -RLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTH 267
             ...::||||.||::|.|:|.:.|.::::|||||.||||..|:|||:.|:.. ::| :|:|::||
  Rat  1034 NEEAQDLSGGMQRKLSVAIAFVGDSKVVVLDEPTSGVDPYSRRSIWDLLLKY-RSG-RTIIMSTH 1096

  Fly   268 YIEEA-RQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLKLSRIQSQK 318
            :::|| .....|.::..|.|....:|..|.:.:.......:..|:..||||:
  Rat  1097 HMDEADLLGDRIAIISQGRLYCSGTPLFLKNCFGTGFYLTLVRKMKNIQSQR 1148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	64/217 (29%)
		ABC_DR_subfamily_A	74..286	CDD:213197	63/213 (30%)
		pip_yhgE_Nterm	427..>474	CDD:276270
		ABC2_membrane_3	429..801	CDD:289468
		ABC2_membrane	601..769	CDD:279410
Abca4	NP_001101191.1	rim_protein	1..2249	CDD:130324	71/247 (29%)
		ABC_subfamily_A	907..1126	CDD:213230	65/223 (29%)
		ABC_subfamily_A	1915..2135	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900