DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and Abca15

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001099763.2	Gene:	Abca15 / 293442	RGDID:	1305981	Length:	1668	Species:	Rattus norvegicus

Alignment Length:	860	Identity:	180/860 - (20%)
Similarity:	323/860 - (37%)	Gaps:	208/860 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDA 131
            |.:..|.:.::|..|.:.:.......:|:|::.|.:|.|..|||.:|.||:|.||.:.|.....:
  Rat   515 PTDLTAGIQIKHLHKVFQENNITKVAINDLSLNVYEGQITVLLGHNGAGKSTTLSILSGLYPPTS 579

  Fly   132 GEIFVLGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNF 196
            ||.:|.|.........: ...:|..||:..|:...::.|.:.::..:.|:.....||....:|:.
  Rat   580 GEAYVHGEDISQHMDQI-RNFLGLCPQQNLLFDHLTVSEHLYFYCRVKGVPQNMCLEETNNMLSA 643

  Fly   197 LDLPSEKR--LVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQ 259
            .:| :|||  ..|:||||.:|:::..:||:...:::||||||.|:||..|:|.|:  |..|....
  Rat   644 FNL-TEKRDAFSKSLSGGMKRKLAIIIALIGGSKVVILDEPTSGMDPASRRSTWD--VVQTYKQN 705

  Fly   260 KTVIITTHYIEEARQ-AHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLK--------LSRIQ 315
            :|:::||||::||.. ...|.:|..|.|             :|.. ..||||        :..::
  Rat   706 RTILLTTHYMDEADMLGDRIAIMVQGTL-------------RCCG-SSVFLKRLYGVGSHIVMVK 756

  Fly   316 SQKGDVTHV---------------NFSNNISL-----HAMAFGSKMDKPSSSQEG-GV--VGLNF 357
            ....||..:               |..|.:|.     :...|.:.:.....:||. |:  .|::.
  Rat   757 EPVCDVDEISKLIHYYIPTATLKTNVGNELSFILPKEYTHKFEALLTALEENQENLGISSFGMSI 821

  Fly   358 HQSKEVLI-----NDSNGSIYTLNQEPYSPPPSRRNNN---------PNDEESCQDCYSNLCKIT 408
            ...:||.:     .||...: ...|.|.:.....||.:         |...|.....::..|.:.
  Rat   822 TTMEEVFLRVSKMEDSKPDM-EATQSPSAGSKGNRNRDVESSMRAGFPTQSEDQTIVFNTGCPLY 885

  Fly   409 SKGKIRALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAIGRDPQGLNLAIVNGEMNDTVRENC 473
            .: :..|:..|.::..|||..|:    ::.::.:::....:.:..:..:..|....::|
  Rat   886 LQ-QFHAMFMKRLMYNWRNWRVL----SVQILGLVISTFLLLKSHEFRHKRIRQMNLDD------ 939

  Fly   474 YWEDGCHFKNLGCRYLSHLNTSVVKTYYEDLDDAKEAVRKGTAWGAVYISENFTDAFIARANLGR 538
            |.:....|..||   .|:|.||::......|......:::.......|:..|
  Rat   940 YGQTIVPFSILG---KSNLTTSLLIHLENMLKPGNHQLKEVQGDLLKYLEGN------------- 988

  Fly   539 DSDDETIDSSEVKVWLDMS--NQQIGVMLNRD------IQLAFRD--FAMGLLGQCGSNPKLGDV 593
               :|.|....|.:.:.::  ..::.|:.|.:      :.||..|  ..|.|.|
  Rat   989 ---EECIHLCIVALSIKVAAGRAKLTVLFNNEAYHSPSLSLAVLDNILFMSLSG----------- 1039

  Fly   594 PIQFRDPIYGTMNPSFTDFVAP--------------GVILTIVFFLAVALTSSALII----ERTE 640
                       .|.|.|.|..|              |.|:.....|.:||..|...|    ||..
  Rat  1040 -----------ANASITVFHKPQPRPTSKEWPRSTYGKIVAFKIQLGMALLVSGFCILTVTERIT 1093

  Fly   641 GLLDRSWVAGVSPFEILFSHVITQFVVMCGQTTLVLIFMLVVFG-------VTNNGDLFWVIVLT 698
            ......:::|.|......|.::..|::.    .:...|:||:|.       ||:...|..:::|.
  Rat  1094 KAKHMQFLSGASVLVYWLSALVFDFIIF----FISCCFLLVMFKYYKIDIYVTDYHILETMLILI 1154

  Fly   699 L-------LQGMCGMCF--------------------GFLISSVCE-----LERNAIQLALGS-- 729
            |       |..:....|                    |.||.::.|     :..|:.|..|.|
  Rat  1155 LFGWSAIPLTYLMSFLFSKSIPAYIQLLVFYYLSGTSGLLIDTIIEAGLSTIISNSTQTFLLSSL 1219

  Fly   730 -FYPTLLLSGVIWPIEGMPVVLRYISLCLPLTLATSSLRSILTRGWAILESDVY------IG-YV 786
             |:||..|...   |....|:.:...||    :...::...|.......:.::|      || |:
  Rat  1220 LFFPTYNLGKC---ISEYTVIYQRKILC----IQQKNVLKYLNCSKEYTKKNIYSLKKPMIGKYL 1277

  Fly   787 STLSWIVGFLVLTLL 801
            ..:| |.||:.|..:
  Rat  1278 IAMS-IAGFVYLLFI 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	67/219 (31%)
		ABC_DR_subfamily_A	74..286	CDD:213197	66/214 (31%)
		pip_yhgE_Nterm	427..>474	CDD:276270	4/46 (9%)
		ABC2_membrane_3	429..801	CDD:289468	80/448 (18%)
		ABC2_membrane	601..769	CDD:279410	45/227 (20%)
Abca15	NP_001099763.2	ABC2_membrane_3	<255..464	CDD:289468
		CcmA	522..834	CDD:224054	84/329 (26%)
		ABC_subfamily_A	522..743	CDD:213230	70/238 (29%)
		ABC2_membrane_3	<1007..1195	CDD:289468	38/213 (18%)
		ABC_subfamily_A	1354..1575	CDD:213230
		drrA	1369..1662	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810