DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and Abca13

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_839990.2	Gene:	Abca13 / 268379	MGIID:	2388707	Length:	5034	Species:	Mus musculus

Alignment Length:	966	Identity:	213/966 - (22%)
Similarity:	352/966 - (36%)	Gaps:	295/966 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 STDSAMAATNNDGGTQPNAVAAWG-APANGPRNTQ------AAVSVRHAFKAYGKKKNANQVLNN 95
            |..|.:...|.|.|.:       | :..|||...:      |.:||.   |.|...|.|.|   .
Mouse  3777 SLSSGLFFFNEDFGNK-------GLSQQNGPGEMEGGNPGVALISVT---KEYEDHKVAVQ---E 3828

  Fly    96 LNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQEI 160
            |.:|..:..|..|||.:|.||||::|.::|.....:|.|.:.|....|..|.| .:.:|..||:.
Mouse  3829 LTLTFHRDQITALLGTNGAGKTTIISMLMGLFPPTSGTITINGKNLQTDLSKV-REELGVCPQQD 3892

  Fly   161 ALYGEFSIQETMMYFG-----WIFGMDTKEILERLQFLLNFLDLPSEKRLVKN-LSGGQQRRVSF 219
            .|....:::|.:|.|.     |   ..|||:.:::...|:.::|...:..... ||||.:|::|.
Mouse  3893 VLLDNLTVREHLMLFASIKAPW---WTTKELQQQVNKTLDEVELTQHQHKPAGVLSGGMKRKLSI 3954

  Fly   220 AVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEAR----------- 273
            .:|.|...:.::||||:.||||..|:|:|:.|:...:.  :|:|.|||:::||.
Mouse  3955 GIAFMGMSKTVVLDEPSSGVDPCSRRSLWDILLKYREG--RTIIFTTHHLDEAEMLSDHVAVLQQ 4017

  Fly   274 -----------------QAHTIGLMRSGHLLAEESP------SVLLSIYKCISLEEVFLKLSRIQ 315
                             |..|:.|.:...:|..:.|      :.|:.||    :.:.|||    .
Mouse  4018 GRLRCYAPPADLKETYGQGLTLTLSKQPSILETQEPKDVARVTSLIQIY----IPQAFLK----D 4074

  Fly   316 SQKGDVTHV---------------NFSNNIS-LHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVL 364
            |..|::|:.               ....|:. ||...:|.   ..::.:|..::.|.....|..:
Mouse  4075 SCGGELTYTIPKDADRTCFKGLCQALDQNLQHLHLTGYGI---SDTTLEEVFLMLLQDTNKKSYI 4136

  Fly   365 INDSN---------GSIYTLNQEPYSPPPSRRNNNPNDEESCQDCYSNLCKITSKGKIRALLTKN 420
            ..|:.         |.:...|..|.|.||  ....|.....||         ...|:..|||.|.
Mouse  4137 TPDNKVEPQNERPVGPLSPHNVSPLSTPP--EGALPEPIGGCQ---------LLLGQAVALLRKR 4190

  Fly   421 M---LRMWRNVGVMLFIFALPVMQVILFC-------LAIGRDPQGLNLAIVNGEMNDTVRENCYW 475
            :   ||.|::....|.   |||:.|.|..       |||...|    |.:..|...  ..|..::
Mouse  4191 LLHTLRAWKSTTSDLL---LPVLFVALAMGLFMVQPLAITYPP----LKLTPGHYE--TAETYFF 4246

  Fly   476 EDGCHFKNLGCRYLSHLNTSVVKTYYEDLDD-AKEAVR-KGTAW--------------------- 517
            ..|.|..:|         |.|:...:.|.|. ..:|.| ..::|
Mouse  4247 SSGNHGPDL---------THVLLRKFRDQDPVCADAFRMNSSSWHRDPYSGPESQDSCGCLKCPN 4302

  Fly   518 ---GAV---------------YISENFTDAFIARANLG---------RDSDDETIDSSE----VK 551
               ||.               |..|.:.....|:..||         .|::|...::|:    .|
Mouse  4303 KSAGAPSLTNCLGHTLLNLSGYDVEEYLLVPSAKPRLGGWSFGGQIPNDAEDVKTNTSKPRTLAK 4367

  Fly   552 VWLDMSN-QQIGVMLNRDIQLA-----------FRDFAMGLLGQCGSNPKLGDVPIQFRDPIYGT 604
            ||.:... ..:...||....|.           :|.:.:.|.    |:|..|  .:...|.|..:
Mouse  4368 VWYNQKGFHSLPSYLNHLNNLILWHHLPANAVDWRQYGITLY----SHPYGG--ALLNEDRILES 4426

  Fly   605 MNPSFTDFVAPGVILTIV--FFLAVALTSSALIIERTEGLLDRSWVAGVSP---------FEILF 658
            :...       ||.|.||  |.:..|...|:::.:|..|......::|:..         :::||
Mouse  4427 IRQC-------GVALCIVLGFSILSASIGSSVVRDRVTGAKRLQHISGLGHRTYWLINFLYDMLF 4484

  Fly   659 SHV-ITQFVVMCGQTTLVLI----------FMLVVFG------------VTNNGDLFWV--IVLT 698
            ..| :...|.:.|...|...          .:|.:||            :.::.|:.::  |.|.
Mouse  4485 YLVSVCLCVAVIGAFQLTAFTFRENLAATALLLALFGYAMIPWMYLMSRIFSSSDVAFISYISLN 4549

  Fly   699 LLQGMCGMCFG------FLISSVCELER--NAIQLALGSFYPTLLLSGVIWPIEGMPVVLRYISL 755
            .:.|:|.|...      .:||....|::  |.::.|. :.:|...|.      :|:      |.|
Mouse  4550 FIFGLCTMLMTTMPRLLAIISKAQNLQKIYNVLKWAF-TIFPQFCLG------QGL------IEL 4601

  Fly   756 CLPLTLATSSLRSILTRGWAILESDVYIG--YVSTLSWIVGFLVLT-----LLVLR 804
            |.      :.::..||..:.|   |.|:.  .::.|.||  |:.||     ||:||
Mouse  4602 CY------NQIKYDLTHNFGI---DSYVSPFEMNFLGWI--FVELTLQGTFLLLLR 4646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	70/250 (28%)
		ABC_DR_subfamily_A	74..286	CDD:213197	69/245 (28%)
		pip_yhgE_Nterm	427..>474	CDD:276270	13/53 (25%)
		ABC2_membrane_3	429..801	CDD:289468	94/495 (19%)
		ABC2_membrane	601..769	CDD:279410	38/211 (18%)
Abca13	NP_839990.2	rim_protein	3036..5019	CDD:130324	213/966 (22%)
		ABC_subfamily_A	3815..4030	CDD:213230	65/226 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	4135..4165		5/29 (17%)
		ABC_subfamily_A	4692..4919	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900