DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and ABCA12

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	XP_011509253.1	Gene:	ABCA12 / 26154	HGNCID:	14637	Length:	2598	Species:	Homo sapiens

Alignment Length:	488	Identity:	123/488 - (25%)
Similarity:	207/488 - (42%)	Gaps:	110/488 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SDPSAIISTDSAMAATNNDGGTQPNAVAAWGAPANGPRNTQAAVSVRHAFKAYGKKKNANQVLNN 95
            ::|||..::...|.::|    .:|.           |::....|::....|.||.|    ..::|
Human  1321 TNPSASKTSPEYMFSSN----IEPE-----------PKDLTVGVALHGVTKIYGSK----VAVDN 1366

  Fly    96 LNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQEI 160
            ||:...:|.|..|||.:|.||||.:|.:.|.....||.|||.|....|....| .|.:|...|..
Human  1367 LNLNFYEGHITSLLGPNGAGKTTTISMLTGLFGASAGTIFVYGKDIKTDLHTV-RKNMGVCMQHD 1430

  Fly   161 ALYGEFSIQETMMYFG------WIFGMDTKEILERLQFLLNFLDLPSEK-RLVKNLSGGQQRRVS 218
            .|:...:.:|.::.:|      |    ..|::.|.::..|....|.|.: :.|..||||.:|::|
Human  1431 VLFSYLTTKEHLLLYGSIKVPHW----TKKQLHEEVKRTLKDTGLYSHRHKRVGTLSGGMKRKLS 1491

  Fly   219 FAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEAR-QAHTIGLMR 282
            .::||:....::|||||:.||||..|:|||: ::...|.. :|:|::||:::||. .:..|..:.
Human  1492 ISIALIGGSRVVILDEPSTGVDPCSRRSIWD-VISKNKTA-RTIILSTHHLDEAEVLSDRIAFLE 1554

  Fly   283 SGHLLAEESPSVL---------LSIYKCIS---------------------LEEVFLKLSRIQSQ 317
            .|.|....||..|         |::.|..|                     |.|.:||    :..
Human  1555 QGGLRCCGSPFYLKEAFGDGYHLTLTKKKSPNLNANAVCDTMAVTAMIQSHLPEAYLK----EDI 1615

  Fly   318 KGDVTHV--NFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLIN-------DSNGSIY 373
            .|::.:|  .||..:|...::....:|........|..|::....:||.:|       :|..|:.
Human  1616 GGELVYVLPPFSTKVSGAYLSLLRALDNGMGDLNIGCYGISDTTVEEVFLNLTKESQKNSAMSLE 1680

  Fly   374 TLNQEPYSPPPSRRNNNPNDEESCQD---CYSNLC----KITSKG-----------KIRALLTK- 419
            .|.|:...      |:|.|...:..|   ..||..    ||.::|           ||.|:|.|
Human  1681 HLTQKKIG------NSNANGISTPDDLSVSSSNFTDRDDKILTRGERLDGFGLLLKKIMAILIKR 1739

  Fly   420 --NMLRMWRNVGVMLFIFALPVMQVILFCLAIG 450
              :..|.|:.      :.|..::.::....|:|
Human  1740 FHHTRRNWKG------LIAQVILPIVFVTTAMG 1766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	72/224 (32%)
		ABC_DR_subfamily_A	74..286	CDD:213197	71/219 (32%)
		pip_yhgE_Nterm	427..>474	CDD:276270	3/24 (13%)
		ABC2_membrane_3	429..801	CDD:289468	3/22 (14%)
		ABC2_membrane	601..769	CDD:279410
ABCA12	XP_011509253.1	ABC2_membrane_3	<1026..1270	CDD:289468
		ZnuC	1349..1573	CDD:224046	75/234 (32%)
		ABC_subfamily_A	1353..1568	CDD:213230	73/225 (32%)
		ABC2_membrane_3	<1916..2177	CDD:289468
		ABC_subfamily_A	2257..2480	CDD:213230
		CcmA	2262..2570	CDD:224054
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810