DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snu and ABCA4

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_000341.2	Gene:	ABCA4 / 24	HGNCID:	34	Length:	2273	Species:	Homo sapiens

Alignment Length:	247	Identity:	73/247 - (29%)
Similarity:	130/247 - (52%)	Gaps:	7/247 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 VSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDAGEIFVLG 138
            |.|::..|.:  :......::.||:|..:..|...||.:|.||||.||.:.|.....:|.:.| |
Human   929 VCVKNLVKIF--EPCGRPAVDRLNITFYENQITAFLGHNGAGKTTTLSILTGLLPPTSGTVLV-G 990

  Fly   139 GKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNFLDLPSEK 203
            |:..........:.:|..||...|:...::.|.|:::..:.|...:|....::.:|....|..::
Human   991 GRDIETSLDAVRQSLGMCPQHNILFHHLTVAEHMLFYAQLKGKSQEEAQLEMEAMLEDTGLHHKR 1055

  Fly   204 -RLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTH 267
             ...::||||.||::|.|:|.:.|.:::||||||.||||..|:|||:.|:.. ::| :|:|::||
Human  1056 NEEAQDLSGGMQRKLSVAIAFVGDAKVVILDEPTSGVDPYSRRSIWDLLLKY-RSG-RTIIMSTH 1118

  Fly   268 YIEEA-RQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLKLSRIQSQK 318
            :::|| .....|.::..|.|....:|..|.:.:.......:..|:..||||:
Human  1119 HMDEADLLGDRIAIIAQGRLYCSGTPLFLKNCFGTGLYLTLVRKMKNIQSQR 1170

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	66/217 (30%)
		ABC_DR_subfamily_A	74..286	CDD:213197	65/213 (31%)
		pip_yhgE_Nterm	427..>474	CDD:276270
		ABC2_membrane_3	429..801	CDD:289468
		ABC2_membrane	601..769	CDD:279410
ABCA4	NP_000341.2	rim_protein	1..2272	CDD:130324	73/247 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	891..911
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1284..1345
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810