Protein Alignment snu and ABCA3

DIOPT Version :10

• Sequence 1: NP_651628.1
• Gene: snu / 43391
• FlyBaseID: FBgn0039594
• Length: 808
• Species: Drosophila melanogaster
• Sequence 2: NP_001080.2
• Gene: ABCA3 / 21
• HGNCID: 33
• Length: 1704
• Species: Homo sapiens
• Alignment Length: 857
• Identity: 182/857 - (21%)
• Similarity: 306/857 - (35%)
• Gaps: 262/857 - (30%)

  Fly    67 PRNTQAAVSVRHAFKAY--GKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIV----- 124
            |.:..|.:.::|..|.:  |.|..|  .:.:||:.:.:|.|..|||.:|.||||.||.:.
Human   523 PEDLVAGIKIKHLSKVFRVGNKDRA--AVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPP 585

  Fly   125 --GRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEIL 187
              ||.|:...||        ::......|.:|..||...|:...::.|.:.::..:.|:..::..
Human   586 TSGRAYISGYEI--------SQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCP 642

  Fly   188 ERLQFLLNFLDLP----SEKRLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIW 248
            |.::.:|:.:.|.    |..|.   ||||.:|::|..:||:...::|||||||.|:|.:.|::||
Human   643 EEVKQMLHIIGLEDKWNSRSRF---LSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIW 704

  Fly   249 NHLVHITKAGQKTVIITTHYIEEA-RQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLKLS 312
            :.|..  :...:|:::|||:::|| .....|.:|..|.|             :|.. ..:|||
Human   705 DLLQR--QKSDRTIVLTTHFMDEADLLGDRIAIMAKGEL-------------QCCG-SSLFLK-- 751

  Fly   313 RIQSQKGDVTHVNFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLINDSNGSIYTLNQ 377
                ||                                  .|..:|.              ||.:
Human   752 ----QK----------------------------------YGAGYHM--------------TLVK 764

  Fly   378 EPYSPPPS----RRNNNPND--EESCQDCYSNLCKITSKGKIRALLTKNMLRMWRNVGVMLFIFA 436
            ||:..|..    ..::.||.  |.|.....|.:....|..:...|..| :.:..:.:|:..|..:
Human   765 EPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAK-LEKKQKELGIASFGAS 828

  Fly   437 LPVMQVILFCLAIGR------DPQGLNLAIVNGEMNDTVRENCYW------------EDGCHFKN 483
            :..|:.:.  |.:|:      |.|.:.|..:..:..   |....|            .||
Human   829 ITTMEEVF--LRVGKLVDSSMDIQAIQLPALQYQHE---RRASDWAVDSNLCGAMDPSDG----- 883

  Fly   484 LGC-----RYLSHLNTSVV---KTYYEDLDDAKEAVRKGTAWGAV-------------------Y 521
            :|.     |....|||.:.   :.::...  .|:|......|..|                   |
Human   884 IGALIEEERTAVKLNTGLALHCQQFWAMF--LKKAAYSWREWKMVAAQVLVPLTCVTLALLAINY 946

  Fly   522 ISENFTDAFIARANLGRDSDDETIDSSEVKVWLDMSNQQIGVMLNRDIQLAFRDFAMGLLGQCGS 586
            .||.|.|..: |..||...  .|:....|.     ...|:|..|:..::.|        |...|.
Human   947 SSELFDDPML-RLTLGEYG--RTVVPFSVP-----GTSQLGQQLSEHLKDA--------LQAEGQ 995

  Fly   587 NPK--LGDVP--IQFRDPIYG-------TMNPSFTDFVAPGVILTIVFFLAVALTSSALIIERTE 640
            .|:  |||:.  :.||..:.|       .:..||.|.....|:..:  |...|..|.|..:...:
Human   996 EPREVLGDLEEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNAL--FNNQAYHSPATALAVVD 1058

  Fly   641 GLLDRSWVAGVSPFEILFSHVITQFVVMCGQTTLVLI--------FMLVVFGVTNNGDLFWVIVL 697
            .||                     |.::||....:::        .:.......|.|...:.|.|
Human  1059 NLL---------------------FKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIAL 1102

  Fly   698 TLLQGMCGMCFGFLISSVCE--LERNAIQLALGSFYPTLLLSGVIWPIEGMPVVLRYISLCLPLT 760
            .||..|..:...|.|.:|.|  ::...:|...|....:..||.::|.:         ||..:|..
Human  1103 NLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDL---------ISFLIPSL 1158

  Fly   761 L------------------ATSSLRSILTRGWAI-----LESDVYIGYVST---------LSWIV 793
            |                  ...:|..:|..||||     |.:..::|..:.         ||.|.
Human  1159 LLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIA 1223

  Fly   794 GFLVLTLLVLRA 805
            .||::|::.:.|
Human  1224 TFLMVTIMRIPA 1235

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	CcmA	74..311	CDD:440746	70/250 (28%)
		YadH	609..807	CDD:440604	47/239 (20%)
ABCA3	NP_001080.2	rim_protein	1..>43	CDD:130324
		rim_protein	<131..1699	CDD:130324	182/857 (21%)