DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and ABCA3

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_001080.2	Gene:	ABCA3 / 21	HGNCID:	33	Length:	1704	Species:	Homo sapiens

Alignment Length:	857	Identity:	182/857 - (21%)
Similarity:	306/857 - (35%)	Gaps:	262/857 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PRNTQAAVSVRHAFKAY--GKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIV----- 124
            |.:..|.:.::|..|.:  |.|..|  .:.:||:.:.:|.|..|||.:|.||||.||.:.
Human   523 PEDLVAGIKIKHLSKVFRVGNKDRA--AVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPP 585

  Fly   125 --GRRYMDAGEIFVLGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEIL 187
              ||.|:...||        ::......|.:|..||...|:...::.|.:.::..:.|:..::..
Human   586 TSGRAYISGYEI--------SQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCP 642

  Fly   188 ERLQFLLNFLDLP----SEKRLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIW 248
            |.::.:|:.:.|.    |..|.   ||||.:|::|..:||:...::|||||||.|:|.:.|::||
Human   643 EEVKQMLHIIGLEDKWNSRSRF---LSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIW 704

  Fly   249 NHLVHITKAGQKTVIITTHYIEEA-RQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLKLS 312
            :.|..  :...:|:::|||:::|| .....|.:|..|.|             :|.. ..:|||
Human   705 DLLQR--QKSDRTIVLTTHFMDEADLLGDRIAIMAKGEL-------------QCCG-SSLFLK-- 751

  Fly   313 RIQSQKGDVTHVNFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLINDSNGSIYTLNQ 377
                ||                                  .|..:|.              ||.:
Human   752 ----QK----------------------------------YGAGYHM--------------TLVK 764

  Fly   378 EPYSPPPS----RRNNNPND--EESCQDCYSNLCKITSKGKIRALLTKNMLRMWRNVGVMLFIFA 436
            ||:..|..    ..::.||.  |.|.....|.:....|..:...|..| :.:..:.:|:..|..:
Human   765 EPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAK-LEKKQKELGIASFGAS 828

  Fly   437 LPVMQVILFCLAIGR------DPQGLNLAIVNGEMNDTVRENCYW------------EDGCHFKN 483
            :..|:.:.  |.:|:      |.|.:.|..:..:..   |....|            .||
Human   829 ITTMEEVF--LRVGKLVDSSMDIQAIQLPALQYQHE---RRASDWAVDSNLCGAMDPSDG----- 883

  Fly   484 LGC-----RYLSHLNTSVV---KTYYEDLDDAKEAVRKGTAWGAV-------------------Y 521
            :|.     |....|||.:.   :.::...  .|:|......|..|                   |
Human   884 IGALIEEERTAVKLNTGLALHCQQFWAMF--LKKAAYSWREWKMVAAQVLVPLTCVTLALLAINY 946

  Fly   522 ISENFTDAFIARANLGRDSDDETIDSSEVKVWLDMSNQQIGVMLNRDIQLAFRDFAMGLLGQCGS 586
            .||.|.|..: |..||...  .|:....|.     ...|:|..|:..::.|        |...|.
Human   947 SSELFDDPML-RLTLGEYG--RTVVPFSVP-----GTSQLGQQLSEHLKDA--------LQAEGQ 995

  Fly   587 NPK--LGDVP--IQFRDPIYG-------TMNPSFTDFVAPGVILTIVFFLAVALTSSALIIERTE 640
            .|:  |||:.  :.||..:.|       .:..||.|.....|:..:  |...|..|.|..:...:
Human   996 EPREVLGDLEEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNAL--FNNQAYHSPATALAVVD 1058

  Fly   641 GLLDRSWVAGVSPFEILFSHVITQFVVMCGQTTLVLI--------FMLVVFGVTNNGDLFWVIVL 697
            .||                     |.::||....:::        .:.......|.|...:.|.|
Human  1059 NLL---------------------FKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIAL 1102

  Fly   698 TLLQGMCGMCFGFLISSVCE--LERNAIQLALGSFYPTLLLSGVIWPIEGMPVVLRYISLCLPLT 760
            .||..|..:...|.|.:|.|  ::...:|...|....:..||.::|.:         ||..:|..
Human  1103 NLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDL---------ISFLIPSL 1158

  Fly   761 L------------------ATSSLRSILTRGWAI-----LESDVYIGYVST---------LSWIV 793
            |                  ...:|..:|..||||     |.:..::|..:.         ||.|.
Human  1159 LLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIA 1223

  Fly   794 GFLVLTLLVLRA 805
            .||::|::.:.|
Human  1224 TFLMVTIMRIPA 1235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	67/230 (29%)
		ABC_DR_subfamily_A	74..286	CDD:213197	66/225 (29%)
		pip_yhgE_Nterm	427..>474	CDD:276270	9/52 (17%)
		ABC2_membrane_3	429..801	CDD:289468	91/469 (19%)
		ABC2_membrane	601..769	CDD:279410	35/202 (17%)
ABCA3	NP_001080.2	ABC2_membrane_3	<271..469	CDD:289468
		CcmA	530..839	CDD:224054	92/394 (23%)
		ABC_subfamily_A	530..751	CDD:213230	69/249 (28%)
		ABC2_membrane_3	923..1261	CDD:289468	73/361 (20%)
		ABC_subfamily_A	1381..1602	CDD:213230
		drrA	1397..1692	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810