DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snu and ABCA2

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_997698.1	Gene:	ABCA2 / 20	HGNCID:	32	Length:	2466	Species:	Homo sapiens

Alignment Length:	662	Identity:	141/662 - (21%)
Similarity:	236/662 - (35%)	Gaps:	197/662 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDA 131
            |.:....|.|....|.|  |.:....||.|::.:.:..:...||.:|.||||.:|.:.|.....:
Human  1014 PTHLPLVVCVDKLTKVY--KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTS 1076

  Fly   132 GEIFVLGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNF 196
            |...:.|....|....: .|.:|..||...|:...:::|.:.::..:..|..:||...:..::..
Human  1077 GSATIYGHDIRTEMDEI-RKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIED 1140

  Fly   197 LDLPSEKR--LVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQ 259
            |:| |.||  ||:.||||.:|::|.|:|.:.....:||||||.||||..|::||: |:...|.|
Human  1141 LEL-SNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWD-LILKYKPG- 1202

  Fly   260 KTVIITTHYIEEA-RQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLKLSRIQSQKGDVTH 323
            :|::::||:::|| .....|.::..|.|....||..|...|                   ||.
Human  1203 RTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTY-------------------GDG-- 1246

  Fly   324 VNFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLINDSNGSIYTLNQEPYSPPPSRRN 388
                     :.:....:..:|...||.|:.                           |.||.|.
Human  1247 ---------YRLTLVKRPAEPGGPQEPGLA---------------------------SSPPGRA- 1274

  Fly   389 NNPNDEESCQDCYSNLCKITSKGKIRALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAIGRDP 453
                ...||           |:.::...:.|:                      :..||.:
Human  1275 ----PLSSC-----------SELQVSQFIRKH----------------------VASCLLV---- 1298

  Fly   454 QGLNLAIVNGEMNDTVRENCYWEDGCHFKNLGCRYLSHLNTSVVKTYYEDLDDAKEAVRKGT--- 515
                        :||..|                 ||::..|             ||.:||.
Human  1299 ------------SDTSTE-----------------LSYILPS-------------EAAKKGAFER 1321

  Fly   516 -------AWGAVYISE-NFTDAFIARANLGRDSDDETIDSSEVKVWLDMSNQQIGVMLNRDIQLA 572
                   :..|:::|. ...|..:....|....:|:::::||.    |:...:..|:...:...:
Human  1322 LFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEA----DVKESRKDVLPGAEGPAS 1382

  Fly   573 FRDFAMGLLGQCG----SNPKL----------GDVPIQFRDPIYGTMNPSFTDFVAP-GVILTIV 622
            ....| |.|.:|.    |...|          ||....:.| :||...|.|.:...| .|.|..|
Human  1383 GEGHA-GNLARCSELTQSQASLQSASSVGSARGDEGAGYTD-VYGDYRPLFDNPQDPDNVSLQEV 1445

  Fly   623 FFLAVA--------LTSSALIIERTEGLLDRSWVAGVSPFEILFSHVITQFVVMCGQTTLVLIFM 679
            ...|::        |....|.:.:..|||.:.:.......:.|||.::.....:|       :.|
Human  1446 EAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQILLPAFFVC-------VAM 1503

  Fly   680 LVVFGVTNNGDL 691
            .|...|...|||
Human  1504 TVALSVPEIGDL 1515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	68/219 (31%)
		ABC_DR_subfamily_A	74..286	CDD:213197	67/214 (31%)
		pip_yhgE_Nterm	427..>474	CDD:276270	5/46 (11%)
		ABC2_membrane_3	429..801	CDD:289468	54/297 (18%)
		ABC2_membrane	601..769	CDD:279410	24/100 (24%)
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	141/662 (21%)
		ABC_subfamily_A	1021..1240	CDD:213230	70/224 (31%)
		ABC_subfamily_A	2081..2304	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810