Protein Alignment snu and ABCA2

DIOPT Version :10

• Sequence 1: NP_651628.1
• Gene: snu / 43391
• FlyBaseID: FBgn0039594
• Length: 808
• Species: Drosophila melanogaster
• Sequence 2: NP_997698.1
• Gene: ABCA2 / 20
• HGNCID: 32
• Length: 2466
• Species: Homo sapiens
• Alignment Length: 662
• Identity: 141/662 - (21%)
• Similarity: 236/662 - (35%)
• Gaps: 197/662 - (29%)

  Fly    67 PRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDA 131
            |.:....|.|....|.|  |.:....||.|::.:.:..:...||.:|.||||.:|.:.|.....:
Human  1014 PTHLPLVVCVDKLTKVY--KDDKKLALNKLSLNLYENQVVSFLGHNGAGKTTTMSILTGLFPPTS 1076

  Fly   132 GEIFVLGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNF 196
            |...:.|....|....: .|.:|..||...|:...:::|.:.::..:..|..:||...:..::..
Human  1077 GSATIYGHDIRTEMDEI-RKNLGMCPQHNVLFDRLTVEEHLWFYSRLKSMAQEEIRREMDKMIED 1140

  Fly   197 LDLPSEKR--LVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQ 259
            |:| |.||  ||:.||||.:|::|.|:|.:.....:||||||.||||..|::||: |:...|.|
Human  1141 LEL-SNKRHSLVQTLSGGMKRKLSVAIAFVGGSRAIILDEPTAGVDPYARRAIWD-LILKYKPG- 1202

  Fly   260 KTVIITTHYIEEA-RQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLKLSRIQSQKGDVTH 323
            :|::::||:::|| .....|.::..|.|....||..|...|                   ||.
Human  1203 RTILLSTHHMDEADLLGDRIAIISHGKLKCCGSPLFLKGTY-------------------GDG-- 1246

  Fly   324 VNFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLINDSNGSIYTLNQEPYSPPPSRRN 388
                     :.:....:..:|...||.|:.                           |.||.|.
Human  1247 ---------YRLTLVKRPAEPGGPQEPGLA---------------------------SSPPGRA- 1274

  Fly   389 NNPNDEESCQDCYSNLCKITSKGKIRALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAIGRDP 453
                ...||           |:.::...:.|:                      :..||.:
Human  1275 ----PLSSC-----------SELQVSQFIRKH----------------------VASCLLV---- 1298

  Fly   454 QGLNLAIVNGEMNDTVRENCYWEDGCHFKNLGCRYLSHLNTSVVKTYYEDLDDAKEAVRKGT--- 515
                        :||..|                 ||::..|             ||.:||.
Human  1299 ------------SDTSTE-----------------LSYILPS-------------EAAKKGAFER 1321

  Fly   516 -------AWGAVYISE-NFTDAFIARANLGRDSDDETIDSSEVKVWLDMSNQQIGVMLNRDIQLA 572
                   :..|:::|. ...|..:....|....:|:::::||.    |:...:..|:...:...:
Human  1322 LFQHLERSLDALHLSSFGLMDTTLEEVFLKVSEEDQSLENSEA----DVKESRKDVLPGAEGPAS 1382

  Fly   573 FRDFAMGLLGQCG----SNPKL----------GDVPIQFRDPIYGTMNPSFTDFVAP-GVILTIV 622
            ....| |.|.:|.    |...|          ||....:.| :||...|.|.:...| .|.|..|
Human  1383 GEGHA-GNLARCSELTQSQASLQSASSVGSARGDEGAGYTD-VYGDYRPLFDNPQDPDNVSLQEV 1445

  Fly   623 FFLAVA--------LTSSALIIERTEGLLDRSWVAGVSPFEILFSHVITQFVVMCGQTTLVLIFM 679
            ...|::        |....|.:.:..|||.:.:.......:.|||.::.....:|       :.|
Human  1446 EAEALSRVGQGSRKLDGGWLKVRQFHGLLVKRFHCARRNSKALFSQILLPAFFVC-------VAM 1503

  Fly   680 LVVFGVTNNGDL 691
            .|...|...|||
Human  1504 TVALSVPEIGDL 1515

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	CcmA	74..311	CDD:440746	72/239 (30%)
		YadH	609..807	CDD:440604	21/92 (23%)
ABCA2	NP_997698.1	rim_protein	58..2398	CDD:130324	141/662 (21%)