DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and abt-4

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_503175.1	Gene:	abt-4 / 178559	WormBaseID:	WBGene00000022	Length:	1802	Species:	Caenorhabditis elegans

Alignment Length:	880	Identity:	183/880 - (20%)
Similarity:	330/880 - (37%)	Gaps:	215/880 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PRNTQAAVSVRHAFKAYGK------------KKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTL 119
            |.:....::|.:..|.||.            |....:.::|||:.:..|....|||.:|.||:|.
Worm   577 PTDLIPTINVVNLTKTYGTSFFKKLFDCKFGKSGEKRAVSNLNLKMYPGQCTVLLGHNGAGKSTT 641

  Fly   120 LSCIVGRRYMDAGEIFV-----LGGKPGTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFG--- 176
            .|.:.|.....:|..:|     ....|..|      :.:|..||...|:|..::.|.:.:|.
Worm   642 FSMLTGVASPSSGSAYVNDFDIRTSLPKIR------REMGLCPQYNTLFGFMTVMEHLEFFAKLK 700

  Fly   177 ---WIFGMDTKEILERLQ--FLLNFLDLPSEKRLVKNLSGGQQRRVSFAVALMHDPELLILDEPT 236
               | ...:.:|||.||:  |..:|        :...|||||:|::|.|:||:...|:::|||||
Worm   701 ERTW-DPEEAREILARLRIDFKADF--------MAGALSGGQKRKLSLAIALIGGSEVVMLDEPT 756

  Fly   237 VGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEEA-RQAHTIGLMRSGHLLAEESPSVLLS--- 297
            .|:||..|...|. |:...|. ::|:::|||::||| .....|.:|..|.|....||..|..
Worm   757 SGMDPGARHETWT-LIQREKE-RRTILLTTHFMEEADLLGDRIAIMAHGQLECCGSPMFLKQQYG 819

  Fly   298 -------IYKCISLEEV---------FLKLSRIQSQKG-DVTHVNFSNNISLHAMAFGSKMDKPS 345
                   :|...|..:|         ::..:.:.|..| :.|::..:.:..:....|....|..:
Worm   820 DGYHLTIVYDTTSTPDVSKTTDIIREYIPEAHVFSYIGQEATYLLSATHRPIFPKLFKELEDHQT 884

  Fly   346 SSQEGGVV--GLNFHQSKEVLINDSNGSIYTLNQEPYSPPPSRRNN----NPNDEESCQDCYSNL 404
               :.|:.  |::....:||.:...:.:     .|.|:......|:    ...|:...||..:.:
Worm   885 ---QCGITSFGVSITTMEEVFLKVGHTA-----DERYNYEHGIENDISEMIEKDDPILQDLRAQV 941

  Fly   405 CKIT----SKGKIRALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAI-------GRDPQGLNL 458
             ::|    .....:|:..|..:..:|.....|.....||..::|.....       .:|||.::|
Worm   942 -RVTGFTLQMQHAKAMFYKRAIFFFRKWTQFLPQLVFPVAYLVLMVFTSQVLPSVKEQDPQTISL 1005

  Fly   459 AIVNGEMNDTVRENCYWEDGCHFKNL--GCRYLSHL----------------NTSVVKTYYEDLD 505
            |    ..:||.:......|..::..|  |.:.||.:                .||.|:.:..|..
Worm  1006 A----PFSDTKKAGHLVSDSGNYVTLLGGSQNLSSMVQGTVTQLGVTQTVVDITSNVEKFIMDQT 1066

  Fly   506 DAKEAVRKGTAWGAVYISENFTDAFIARANLGRDSDDETIDSSEVKVWLDMSNQQIGVMLNRDIQ 570
            :|..:...|..:...::...|              :..|:....:|.:.:    ..| :....:.
Worm  1067 NAMGSRTFGLHYALGFVPSMF--------------NFSTVSVPSLKTFFN----NFG-LYTPALA 1112

  Fly   571 LAFRDFAMGLLGQ---------CGSNPKLGDVPIQFRDPIYGTMNPSFTDF-VAPGVILTIVFFL 625
            :.|.|..  :|.|         ..::|    :|...:|.:..|.......| :|.|:|::  |.:
Worm  1113 ITFTDSM--ILSQKQKKQYSFTAVNHP----LPPSTQDTLKNTNRSDGAAFLIAYGLIVS--FAV 1169

  Fly   626 AVALTSSALIIER--------------------TEGLLDRSW-VAGVSPFEILF--------SHV 661
            .||..|..||.||                    |..:.|.:| |..:..|:.:|        :|
Worm  1170 CVAGYSQFLITERKKKSKHMQLLSGIRPWMFWLTAFIWDAAWFVIRILCFDAIFYIFNITAYTH- 1233

  Fly   662 ITQFVVMCGQTTLVLIFMLVVFGVTNNGDLFW--------------VIVLTLLQGMCGMCFGFLI 712
              .|.||     |:|....:::|.|.....:|              |.:..:|.||.|.....:|
Worm  1234 --DFGVM-----LILTLSFLLYGWTALPFTYWFQFFFESAPKGFMMVTMYHILTGMIGSIAVPII 1291

  Fly   713 SSVCELERNAI-QLALGSFYPTLLLS---GVIWPIEGMPVVLRYISLCLPLTLA------TSSLR 767
            |....|:...: .:.....:||..:|   .|.:..|.:.:..:.:...:|:..|      |:|.|
Worm  1292 SQTSSLDAGYLWSIIFAWLFPTYNISQIATVTFQNENVRIACKKLDCTIPMFKAVTACCGTASER 1356

  Fly   768 ----SILTRG--WAILESDVYIGYVSTLSWIVGFL 796
                ::|..|  ..||...:::.....:.||..|:
Worm  1357 LYVDNVLFVGNRKGILVYVIFLAVQGFIYWIWVFM 1391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	71/242 (29%)
		ABC_DR_subfamily_A	74..286	CDD:213197	70/237 (30%)
		pip_yhgE_Nterm	427..>474	CDD:276270	11/53 (21%)
		ABC2_membrane_3	429..801	CDD:289468	86/462 (19%)
		ABC2_membrane	601..769	CDD:279410	46/225 (20%)
abt-4	NP_503175.1	ABC2_membrane_3	<281..523	CDD:289468
		NosY	<377..524	CDD:224196
		CcmA	581..905	CDD:224054	86/343 (25%)
		ABC_subfamily_A	586..815	CDD:213230	73/245 (30%)
		ABC2_membrane_3	<1078..1318	CDD:289468	49/274 (18%)
		ABC_subfamily_A	1450..1668	CDD:213230
		drrA	1457..1755	CDD:130256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810