DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and abt-2

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_490949.3	Gene:	abt-2 / 171782	WormBaseID:	WBGene00000020	Length:	2146	Species:	Caenorhabditis elegans

Alignment Length:	863	Identity:	178/863 - (20%)
Similarity:	326/863 - (37%)	Gaps:	238/863 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 PRNTQAAVSVRHAFKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRYMDA 131
            |.|...||.:....|.|   :|..:.|:.||:.:.:|.|.||||.:|.||||.:|.:.|.....:
Worm   922 PTNLTLAVHINSMSKVY---ENGTKALDCLNLRLYEGQITGLLGHNGAGKTTTMSILCGLYAPSS 983

  Fly   132 GEIFVLGGKPGTRGSGVPGKRV----GYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQF 192
            |.     .|...|......:||    |..||...|:...::.|.:..|..:.|:...|:..::..
Worm   984 GT-----AKIYQRDIRTDLRRVRDVLGICPQHNVLFSHLTVSEQLRLFAALKGVPDSELTSQVDE 1043

  Fly   193 LLNFLDLPSEK--RLVKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHIT 255
            :|..:.| :||  :|...||||.:||:...:|.:.....:||||||.|||...|:.||. |:...
Worm  1044 ILASVSL-TEKANKLASTLSGGMKRRLCIGIAFIGGSRFVILDEPTAGVDVTARKDIWK-LLQRN 1106

  Fly   256 KAGQKTVIITTHYIEEA---------------------------RQAHTIGLMRSGHLLAEESP- 292
            |.| :|::::||:::||                           :..:.:.:.|..:.|..:..
Worm  1107 KEG-RTILLSTHHMDEADVLSDRIAILSQDFEKPDLLDGKRLIFQHFYALLVCRINYTLKSKRTF 1170

  Fly   293 --SVLLSIYKCISLEEVFLKLSRIQSQKGDV--------------------------THVNFSNN 329
              .|::.:: .::|.|:|: |.::.:.:.|:                          |..|.:.|
Worm  1171 LFQVIIPLF-LLALAELFV-LLQVSTARPDLMVSMPPLPLETSIMGNHSDFYVNSWDTAENSTAN 1233

  Fly   330 ISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLINDSNGSIYTLNQE----------PYSPPP 384
            ..|||| |.|....|..             :|:|    .|..:.|:.:|          ...|.|
Worm  1234 DILHAM-FSSPGTGPRC-------------AKDV----PNDLLDTMRRELMFRNRYGFGRNKPAP 1280

  Fly   385 SRRNNNPNDEESCQDCYSNLCKITSKGKIRALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAI 449
            ....::.::|..||:.         :|:..  .|:::.....|..:              :|
Worm  1281 GVDKDSVDNEYQCQNI---------QGEFD--YTEDISNATYNAPI--------------YC--- 1317

  Fly   450 GRDPQGLNLAIVNGEMNDT------VRENCYWEDGCHFKN------------------LGCRYLS 490
            |.:..|.|..:.:.:.|:|      ..:..:...|.:...                  ||...|.
Worm  1318 GCEDFGWNCTLEDWKWNETNWLRLNTTDRIFDLTGRNLTQFRLITRFAQLANTTAPFFLGGFSLG 1382

  Fly   491 HLNTSVVKTYYEDLDDAK----EAVRKGTAWGAVYISENFT----------DAFIARANLGRDSD 541
            |:|.....  ..|:|.:|    |.: |..|.....|:.|.|          |.|.....|.:..:
Worm  1383 HVNQRAQS--QADIDTSKRGWLETI-KDIAQSMRIINLNTTGIEPATPKVLDPFAQNITLNQVVN 1444

  Fly   542 D--ETIDSSE-VKVWLD---------MSNQQIGVMLNRDIQLAFRDFA-----MGLLGQCGSNPK 589
            |  :.:|..| ||||.:         .||.....:|.::      |:|     :|:|
Worm  1445 DLLQNLDVRENVKVWFNNKIWPGFPIASNILSNALLRQE------DYAIDPEDLGIL-------- 1495

  Fly   590 LGDVPIQFRDPIYGTMNPS-------FTDFVAPG--VILTIVFFLAVALTSSALIIERTEGLLDR 645
                  ....|:..|::.:       ||..:|..  .||.:|..:..|..:..|:.:|....|..
Worm  1496 ------TMNHPMNKTISQTLDQNALKFTQALAVFRITILLLVLSMIPAGFTVYLVEDRICEALHL 1554

  Fly   646 SWVAGVSPFEILFSHVITQFVVMCGQTTLVLIFMLV-----VFGVTNNGDLFWV-IVLTLLQGMC 704
            ..|.|:.......:..:...||   .|.::::.||:     |...|.:|..|:. ::|..:.||.
Worm  1555 QLVGGLRKVTYWVTSYLYDMVV---YTLVIIVIMLIYLCFRVSDFTADGATFFAFLLLFFVHGMS 1616

  Fly   705 GMCFGFLIS---SVCELERNAIQLALGSFYPTLLLSGVIWPIEGM----PVVLRYISLC--LPLT 760
            .:.:.::..   ||..|  :.:.:|:||::..::.:..:..:|.:    |.::...::|  :.|.
Worm  1617 TILYAYVFQKAFSVAAL--SFVLIAIGSYFVGIVCALTVIMLESLMVQDPSLIPAHTVCSIVFLV 1679

  Fly   761 LATSSLRSILTRGWAILE 778
            |...:|...:.||..|.:
Worm  1680 LPQYNLGIAIFRGLMIYQ 1697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	68/249 (27%)
		ABC_DR_subfamily_A	74..286	CDD:213197	66/244 (27%)
		pip_yhgE_Nterm	427..>474	CDD:276270	7/52 (13%)
		ABC2_membrane_3	429..801	CDD:289468	79/429 (18%)
		ABC2_membrane	601..769	CDD:279410	37/191 (19%)
abt-2	NP_490949.3	rim_protein	39..2117	CDD:130324	178/863 (21%)
		ABC_subfamily_A	929..1134	CDD:213230	65/215 (30%)
		ABC_subfamily_A	1802..2024	CDD:213230
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0059
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810