DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment snu and Abcg8

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_569098.2	Gene:	Abcg8 / 155192	RGDID:	620300	Length:	672	Species:	Rattus norvegicus

Alignment Length:	772	Identity:	163/772 - (21%)
Similarity:	270/772 - (34%)	Gaps:	256/772 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 FKAYGKKKNANQVLNNLNMTVPKGTIYGLLGASGCGKTTLLSCIVGRRY---MDAGEIFVLGGKP 141
            :::.|.:.:.:..:.||:..|..|.:..::|::|||:.|||..|.||.:   |.:|:|:: .|:|
  Rat    75 WRSRGSQDSWDLGIRNLSFKVRSGQMLAIIGSAGCGRATLLDVITGRDHGGKMKSGQIWI-NGQP 138

  Fly   142 GTRGSGVPGKRVGYMPQEIALYGEFSIQETMMYFGWIFGMDTKEILERLQFLLNFLDLPSEKRL- 205
            .|  ..:..|.|.::.|:..|....:::||:.:   |..|...:...:.|......|:.:|.||
  Rat   139 ST--PQLIQKCVAHVRQQDQLLPNLTVRETLTF---IAQMRLPKTFSQAQRDKRVEDVIAELRLR 198

  Fly   206 -----------VKNLSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQ 259
                       |:.:|||::||||..|.|:.:|.:|||||||.|:|.....::...|..:.| |.
  Rat   199 QCANTRVGNTYVRGVSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVRTLSRLAK-GN 262

  Fly   260 KTVIITTHYIEEARQAHTIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLKLSRIQSQKGDVTH- 323
            :.|:|:.|.            .||             .|::...|  |.|..|......|...|
  Rat   263 RLVLISLHQ------------PRS-------------DIFRLFDL--VLLMTSGTPIYLGVAQHM 300

  Fly   324 VNFSNNISLHAMAFGSKMDKPSSSQEGGVVGLNFHQSKEVLINDSNGSIYTLNQEPYSPPPSRRN 388
            |.:..:|..                                                   |..|.
  Rat   301 VQYFTSIGY---------------------------------------------------PCPRY 314

  Fly   389 NNPNDEESCQDCYSNLCKITSKGKIRALLTKNMLRMWRNVGVMLFIFALPVMQVILFCLAIGRDP 453
            :||      .|.|.:|..|..:.|.:.:.|....|:         :.||.:.:|
  Rat   315 SNP------ADFYVDLTSIDRRSKEQEVATMEKARL---------LAALFLEKV----------- 353

  Fly   454 QGLNLAIVNGEMNDTVRENCYWEDGCHFKNLGCRYLSHLNTSVVKTYYEDLDDAKEAVRKGTAWG 518
            ||.              ::..|                                 :|..|....|
  Rat   354 QGF--------------DDFLW---------------------------------KAEAKSLDTG 371

  Fly   519 AVYISENFTDAFIARANLGRDSDDETIDSSEVKVWLDMSNQQIGVMLNRDIQLAFRD----FAMG 579
            ...:|:..|.    ..|.|..::            |....||...::.|.|...|||    |..|
  Rat   372 TYAVSQTLTQ----DTNCGTAAE------------LPGMIQQFTTLIRRQISNDFRDLPTLFIHG 420

  Fly   580 LLGQCGSNPKLG-------DVPIQFRDP-----IYGTMNPSFTDFVAPGVILTIVFFLAVALTSS 632
             ...|..:..:|       |.|:.|.|.     :.|.:.|.       .|||.:|  .......|
  Rat   421 -AEACLMSLIIGFLYYGHADKPLSFMDMAALLFMIGALIPF-------NVILDVV--SKCHSERS 475

  Fly   633 ALIIERTEGLLDRSWVAGVSPFEILFSHVITQFVVMCGQTTLVLIFMLVVFGVTN---NGDLF-- 692
            .|..|..:||    :.||  |:  .|:.|:.:....|   ..|:|:.:.::.:||   ..:||
  Rat   476 LLYYELEDGL----YTAG--PY--FFAKVLGELPEHC---AYVIIYGMPIYWLTNLRPGPELFLL 529

  Fly   693 -----WVIVL---TLLQGMCGMCFGFLISSVCELERNAIQLALGSFYPTLLLSGVIWPIEGMPVV 749
                 |::|.   |:......|...|.:||.|   .||:   ..|||   |.:|.:..:..:.:|
  Rat   530 HFMLLWLVVFCCRTMALAASAMLPTFHMSSFC---CNAL---YNSFY---LTAGFMINLNNLWIV 585

  Fly   750 LRYISLCLPLTLATSSLRSILTRGWAILESDVYIGYVSTLSWIV-GFLVLTLLVLRA 805
            ..:||....|....|.|..|...|      .:|...:..|::.| |..::|.:.|.:
  Rat   586 PAWISKMSFLRWCFSGLMQIQFNG------HIYTTQIGNLTFSVPGDAMVTAMDLNS 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	62/224 (28%)
		ABC_DR_subfamily_A	74..286	CDD:213197	62/220 (28%)
		pip_yhgE_Nterm	427..>474	CDD:276270	5/46 (11%)
		ABC2_membrane_3	429..801	CDD:289468	80/401 (20%)
		ABC2_membrane	601..769	CDD:279410	44/180 (24%)
Abcg8	NP_569098.2	ABCG_White	60..295	CDD:213201	67/253 (26%)
		3a01204	88..662	CDD:273361	162/759 (21%)
		ABC2_membrane	401..605	CDD:279410	57/233 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000