DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment snu and Abcg5

DIOPT Version :9

Sequence 1:	NP_651628.1	Gene:	snu / 43391	FlyBaseID:	FBgn0039594	Length:	808	Species:	Drosophila melanogaster
Sequence 2:	NP_446206.2	Gene:	Abcg5 / 114628	RGDID:	620298	Length:	652	Species:	Rattus norvegicus

Alignment Length:	703	Identity:	154/703 - (21%)
Similarity:	255/703 - (36%)	Gaps:	213/703 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ANGPRNTQAAVS-----------VRHAFKAYG------------------KKKNANQVLNNLNMT 99
            |.||.|.:.:.|           .||:.....                  ::|...::|.::::.
  Rat    12 ARGPHNNRGSQSSLEEGSVTGSEARHSLGVLNVSFSVSNRVGPWWNIKSCQQKWDRKILKDVSLY 76

  Fly   100 VPKGTIYGLLGASGCGKTTLLSCIVGRRYMDA---GEIFVLGGKPGTRGSGVPGKR------VGY 155
            :..|....:||:||.||||||..|.||.....   ||:||         :|...:|      |.|
  Rat    77 IESGQTMCILGSSGSGKTTLLDAISGRLRRTGTLEGEVFV---------NGCELRRDQFQDCVSY 132

  Fly   156 MPQEIALYGEFSIQETMMYFGWI---------FGMDTKEILERLQFLLNFLDLPSEKRLVKN--- 208
            :.|........:::||:.|...:         :....:.:|..|. |.:..|     :::.|
  Rat   133 LLQSDVFLSSLTVRETLRYTAMLALRSSSADFYDKKVEAVLTELS-LSHVAD-----QMIGNYNF 191

  Fly   209 --LSGGQQRRVSFAVALMHDPELLILDEPTVGVDPLLRQSIWNHLVHITKAGQKTVIITTHYIEE 271
              :|.|::||||.|..|:.||::::|||||.|:|.:....|...||.:.:. .:.||:|.|....
  Rat   192 GGISSGERRRVSIAAQLLQDPKVMMLDEPTTGLDCMTANHIVLLLVELARR-NRIVIVTIHQPRS 255

  Fly   272 ARQAH--TIGLMRSGHLLAEESPSVLLSIYKCISLEEVFLKLSRIQSQKGDVTHVNFSNNISL-- 332
            ....|  .|.::..|.|:...:|..:|                            .|.||...
  Rat   256 ELFHHFDKIAILTYGELVFCGTPEEML----------------------------GFFNNCGYPC 292

  Fly   333 --HAMAFGSKMDKPS---SSQEGGV--------VGLNFHQS---KEVLIN-DSNGSIYTLNQEPY 380
              |:..|...||..|   .|:|..:        :...|.||   .::|.| :....:.||...|:
  Rat   293 PEHSNPFDFYMDLTSVDTQSREREIETYKRVQMLESAFRQSDICHKILENIERTRHLKTLPMVPF 357

  Fly   381 SPPPSRRNNNPNDEESCQDCYSNLCKITSKGKIRALLTKNM--------LRMWRN--VGVMLFIF 435
                  :..||.         ...||:   |.:...:|:|:        :|:.:|  :|:.|..:
  Rat   358 ------KTKNPP---------GMFCKL---GVLLRRVTRNLMRNKQVVIMRLVQNLIMGLFLIFY 404

  Fly   436 ALPVM----------QVILFCLAIGRDP-----QGLNLAIVNGEMNDTVRENCYWEDGCHFK-NL 484
            .|.|.          :|.|....:|..|     ..:||..:...::|  :|:   :||.:.| .:
  Rat   405 LLRVQNNMLKGAVQDRVGLLYQLVGATPYTGMLNAVNLFPMLRAVSD--QES---QDGLYQKWQM 464

  Fly   485 GCRYLSH-LNTSVVKTY------YEDLDDAKEAVRKGTAWGAVYISENFTDAFIARANLGRDSDD 542
            ...|:.| |..|:|.|.      |..|....|..|.| .:.|..::.:....|:....||...:.
  Rat   465 LLAYVLHALPFSIVATVIFSSVCYWTLGLYPEVARFG-YFSAALLAPHLIGEFLTLVLLGMVQNP 528

  Fly   543 ETIDSSEVKVWLDMSNQQIGVMLNRDIQ---------------------LAFRDFAMGLLGQC-G 585
            ..::|  :...|.:|...||....|:|:                     |...:| .||...| |
  Rat   529 NIVNS--IVALLSISGLLIGSGFIRNIEEMPIPLKILGYFTFQKYCCEILVVNEF-YGLNFTCGG 590

  Fly   586 SNPKLGDVP-------IQFRDPIYGTMNPSFT-------DFVAPGVILTIVFF 624
            ||..:.:.|       |||.:.........||       .|:...|||.:|.|
  Rat   591 SNTSVPNNPMCSMTQGIQFIEKTCPGATSRFTTNFLILYSFIPTLVILGMVVF 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
snu	NP_651628.1	LolD	73..290	CDD:224059	64/270 (24%)
		ABC_DR_subfamily_A	74..286	CDD:213197	63/265 (24%)
		pip_yhgE_Nterm	427..>474	CDD:276270	13/63 (21%)
		ABC2_membrane_3	429..801	CDD:289468	57/255 (22%)
		ABC2_membrane	601..769	CDD:279410	8/31 (26%)
Abcg5	NP_446206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		5/17 (29%)
		ABCG_White	50..276	CDD:213201	61/241 (25%)
		3a01204	61..646	CDD:273361	147/654 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000